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Map3k6 mitogen-activated protein kinase kinase kinase 6 [ Mus musculus (house mouse) ]

Gene ID: 53608, updated on 27-Nov-2024

Summary

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Official Symbol
Map3k6provided by MGI
Official Full Name
mitogen-activated protein kinase kinase kinase 6provided by MGI
Primary source
MGI:MGI:1855691
See related
Ensembl:ENSMUSG00000028862 AllianceGenome:MGI:1855691
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ask2; MEKK6; MAPKKK6
Summary
Predicted to enable ATP binding activity; MAP kinase kinase kinase activity; and magnesium ion binding activity. Predicted to be involved in JNK cascade; p38MAPK cascade; and protein phosphorylation. Is expressed in heart and vibrissa. Orthologous to human MAP3K6 (mitogen-activated protein kinase kinase kinase 6). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in large intestine adult (RPKM 10.4), genital fat pad adult (RPKM 9.5) and 21 other tissues See more
Orthologs
human all
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Genomic context

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See Map3k6 in Genome Data Viewer
Location:
4 D2.3; 4 66.25 cM
Exon count:
29
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (132965290..132980240)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (133237979..133252929)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene G-protein coupled receptor 3 Neighboring gene CD164 sialomucin-like 2 Neighboring gene ficolin C pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E2126 Neighboring gene synaptotagmin-like 1 Neighboring gene transmembrane protein 222 Neighboring gene STARR-seq mESC enhancer starr_11620

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. ASK1/2 signaling promotes inflammation in a mouse model of neutrophilic dermatosis. Tartey S, et al. J Clin Invest, 2018 May 1. PMID 29629899, Free PMC Article
  2. ASK family kinases mediate cellular stress and redox signaling to circadian clock. Imamura K, et al. Proc Natl Acad Sci U S A, 2018 Apr 3. PMID 29555767, Free PMC Article
  3. ASK1 and ASK2 differentially regulate the counteracting roles of apoptosis and inflammation in tumorigenesis. Iriyama T, et al. EMBO J, 2009 Apr 8. PMID 19214184, Free PMC Article
  4. Mitogen-activated protein 3 kinase 6 mediates angiogenic and tumorigenic effects via vascular endothelial growth factor expression. Eto N, et al. Am J Pathol, 2009 Apr. PMID 19246638, Free PMC Article
  5. Rac1/osmosensing scaffold for MEKK3 contributes via phospholipase C-gamma1 to activation of the osmoprotective transcription factor NFAT5. Zhou X, et al. Proc Natl Acad Sci U S A, 2011 Jul 19. PMID 21712438, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. the present study identifies SHP-1 and ASK signaling crosstalk as a critical regulator of IL-1alpha-driven inflammation and opens future avenues for finding novel drug targets to treat neutrophilic dermatosis
    Title: ASK1/2 signaling promotes inflammation in a mouse model of neutrophilic dermatosis.
  2. the ASK1/2 complex is a regulator of NLRP3 activation
    Title: ASK Family Kinases Are Required for Optimal NLRP3 Inflammasome Priming.
  3. Data show that deletion of either MAPKKK5 ASK1 or MAPKKK6 ASK2 in mice promoted the replication of influenza A virus in the lung.
    Title: The ASK family kinases differentially mediate induction of type I interferon and apoptosis during the antiviral response.
  4. Apoptosis signal-regulating kinase (ASK) 2 functions as a mitogen-activated protein kinase kinase kinase in a heteromeric complex with ASK1.
    Title: Apoptosis signal-regulating kinase (ASK) 2 functions as a mitogen-activated protein kinase kinase kinase in a heteromeric complex with ASK1.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (1)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC159280

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding ISO
Inferred from Sequence Orthology
more info
  
enables JUN kinase kinase kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables MAP kinase kinase kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables MAP kinase kinase kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables magnesium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in JNK cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in MAPK cascade IEA
Inferred from Electronic Annotation
more info
  
involved_in p38MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
mitogen-activated protein kinase kinase kinase 6
Names
apoptosis signal-regulating kinase 2
NP_057902.5
XP_006539103.1
XP_006539104.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016693.5 → NP_057902.5  mitogen-activated protein kinase kinase kinase 6

    Status: VALIDATED

    Source sequence(s)
    AL671882, AL837525
    Consensus CDS
    CCDS18744.1
    UniProtKB/Swiss-Prot
    A2AE93, Q0VBN3, Q9WTR2
    UniProtKB/TrEMBL
    A0A0A0MQ82
    Related
    ENSMUSP00000030677.7, ENSMUST00000030677.7
    Conserved Domains (3) summary
    smart00220
    Location:654 → 907
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06624
    Location:640 → 907
    STKc_ASK; Catalytic domain of the Serine/Threonine Kinase, Apoptosis signal-regulating kinase
    pfam13281
    Location:130 → 507
    DUF4071; Domain of unknown function (DUF4071)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    132965290..132980240
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006539040.4 → XP_006539103.1  mitogen-activated protein kinase kinase kinase 6 isoform X1

    UniProtKB/Swiss-Prot
    A2AE93, Q0VBN3, Q9WTR2
    Conserved Domains (2) summary
    cd06624
    Location:632 → 899
    STKc_ASK; Catalytic domain of the Serine/Threonine Kinase, Apoptosis signal-regulating kinase
    pfam13281
    Location:130 → 500
    DUF4071; Domain of unknown function (DUF4071)

  2. XM_006539041.4 → XP_006539104.1  mitogen-activated protein kinase kinase kinase 6 isoform X2

    Conserved Domains (1) summary
    pfam13281
    Location:130 → 508
    DUF4071; Domain of unknown function (DUF4071)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9WTR2.4 GenPept UniProtKB/Swiss-Prot:Q9WTR2

Gene LinkOut

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