U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Zpbp zona pellucida binding protein [ Mus musculus (house mouse) ]

Gene ID: 53604, updated on 27-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Zpbpprovided by MGI
Official Full Name
zona pellucida binding proteinprovided by MGI
Primary source
MGI:MGI:1855701
See related
Ensembl:ENSMUSG00000020193 AllianceGenome:MGI:1855701
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Sp38; Iam38; 4930486K01Rik
Summary
Acts upstream of or within acrosome assembly and binding activity of sperm to zona pellucida. Located in acrosomal vesicle and cell body. Part of zona pellucida receptor complex. Human ortholog(s) of this gene implicated in spermatogenic failure 66. Orthologous to human ZPBP (zona pellucida binding protein). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in testis adult (RPKM 21.9) and CNS E11.5 (RPKM 0.5) See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Zpbp in Genome Data Viewer
Location:
11 A1; 11 6.76 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (11229624..11414222, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (11279624..11464223, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_28579 Neighboring gene STARR-seq mESC enhancer starr_28580 Neighboring gene 60S ribosomal protein L36 pseudogene Neighboring gene STARR-seq mESC enhancer starr_28581 Neighboring gene STARR-seq mESC enhancer starr_28583 Neighboring gene STARR-seq mESC enhancer starr_28584 Neighboring gene STARR-seq mESC enhancer starr_28585 Neighboring gene STARR-seq mESC enhancer starr_28586 Neighboring gene STARR-seq mESC enhancer starr_28587 Neighboring gene STARR-seq mESC enhancer starr_28588 Neighboring gene STARR-seq mESC enhancer starr_28589 Neighboring gene STARR-seq mESC enhancer starr_28590 Neighboring gene STARR-seq mESC enhancer starr_28591 Neighboring gene STARR-seq mESC enhancer starr_28592 Neighboring gene STARR-seq mESC enhancer starr_28593 Neighboring gene von Willebrand factor C domain containing 2 Neighboring gene STARR-seq mESC enhancer starr_28594 Neighboring gene predicted gene, 39578 Neighboring gene BRCA1/BRCA2-containing complex, subunit 3 pseudogene Neighboring gene STARR-seq mESC enhancer starr_28595 Neighboring gene STARR-positive B cell enhancer mm9_chr11:11361594-11361894 Neighboring gene STARR-positive B cell enhancer ABC_E10664 Neighboring gene STARR-positive B cell enhancer ABC_E8871 Neighboring gene predicted gene, 26458 Neighboring gene TGF beta-inducible nuclear protein 1 pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:11428864-11429017 Neighboring gene STARR-positive B cell enhancer ABC_E2348 Neighboring gene sperm microtubule inner protein 7 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:11464295-11464600 Neighboring gene STARR-seq mESC enhancer starr_28596 Neighboring gene RIKEN cDNA 4930512M02 gene Neighboring gene STARR-seq mESC enhancer starr_28597 Neighboring gene predicted gene, 29945 Neighboring gene predicted gene 11998

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. The origin and assembly of a zona pellucida binding protein, IAM38, during spermiogenesis. Yu Y, et al. Microsc Res Tech, 2009 Aug. PMID 19204925
  2. Molecular and immunological approaches to mammalian fertilization. Mori T, et al. J Reprod Immunol, 2000 Jul. PMID 10924747
  3. SPACA1-deficient male mice are infertile with abnormally shaped sperm heads reminiscent of globozoospermia. Fujihara Y, et al. Development, 2012 Oct. PMID 22949614
  4. Loss of zona pellucida binding proteins in the acrosomal matrix disrupts acrosome biogenesis and sperm morphogenesis. Lin YN, et al. Mol Cell Biol, 2007 Oct. PMID 17664285, Free PMC Article
  5. Differentially expressed genes in adipose tissues of high body weight-selected (obese) and unselected (lean) mouse lines. Aksu S, et al. J Appl Genet, 2007. PMID 17495347

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in acrosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within acrosome assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in binding of sperm to zona pellucida IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within binding of sperm to zona pellucida IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in acrosomal membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in acrosomal vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in acrosomal vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in acrosomal vesicle ISO
Inferred from Sequence Orthology
more info
  
located_in cell body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
part_of zona pellucida receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of zona pellucida receptor complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
zona pellucida-binding protein 1
Names
inner acrosomal membrane IAM38

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001185153.1 → NP_001172082.1  zona pellucida-binding protein 1 isoform 2

    See identical proteins and their annotated locations for NP_001172082.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AL662805, AL663071, BC145628
    UniProtKB/Swiss-Prot
    Q62522, Q9CR97
    UniProtKB/TrEMBL
    B7ZP49
    Conserved Domains (2) summary
    pfam07354
    Location:87 → 350
    Sp38; Zona-pellucida-binding protein (Sp38)
    smart00410
    Location:98 → 151
    IG_like; Immunoglobulin like

  2. NM_015785.2 → NP_056600.1  zona pellucida-binding protein 1 isoform 1

    See identical proteins and their annotated locations for NP_056600.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL662805, AL663071, BC139450
    Consensus CDS
    CCDS24434.1
    UniProtKB/Swiss-Prot
    Q62522, Q9CR97
    UniProtKB/TrEMBL
    Q5NC84
    Related
    ENSMUSP00000020413.4, ENSMUST00000020413.4
    Conserved Domains (2) summary
    pfam07354
    Location:144 → 407
    Sp38; Zona-pellucida-binding protein (Sp38)
    smart00410
    Location:155 → 208
    IG_like; Immunoglobulin like

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    11229624..11414222 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030246152.2 → XP_030102012.1  zona pellucida-binding protein 1 isoform X2

    Conserved Domains (1) summary
    pfam07354
    Location:102 → 275
    Sp38; Zona-pellucida-binding protein (Sp38)

  2. XM_006514755.4 → XP_006514818.1  zona pellucida-binding protein 1 isoform X2

    Conserved Domains (1) summary
    pfam07354
    Location:102 → 275
    Sp38; Zona-pellucida-binding protein (Sp38)

  3. XM_011243736.4 → XP_011242038.1  zona pellucida-binding protein 1 isoform X1

    Conserved Domains (2) summary
    smart00409
    Location:155 → 208
    IG; Immunoglobulin
    pfam07354
    Location:234 → 292
    Sp38; Zona-pellucida-binding protein (Sp38)

RNA

  1. XR_004936990.1 RNA Sequence

  2. XR_380974.5 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q62522.2 GenPept UniProtKB/Swiss-Prot:Q62522

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools