Prx4 Peroxiredoxin 4 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Prx4provided by FlyBase
Official Full Name: Peroxiredoxin 4provided by FlyBase
Primary source: FLYBASE:FBgn0040308
Locus tag: Dmel_CG1274
See related: AllianceGenome:FB:FBgn0040308
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 1274; CG1274; Dmel\CG1274; dPRDX4; dPrx4; DPx-4156; DPx4156; Jafrac; Jafrac-2; jafrac2; Jafrac2; JafRac2; Prx4156; thioredoxin peroxidase 2 isoform A
Summary: Enables thioredoxin-dependent peroxiredoxin activity. Involved in several processes, including cellular response to cold; hydrogen peroxide catabolic process; and positive regulation of receptor signaling pathway via JAK-STAT. Located in cytosol; endoplasmic reticulum; and extracellular space. Is expressed in several structures, including adult head; adult heart; embryonic/larval midgut primordium; gland; and gut section. Orthologous to human PRDX4 (peroxiredoxin 4). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 63A3-63A3; 3-5 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (3042359..3044174)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (3042359..3044174)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Peroxiredoxin 4 controls the immune and cell death responses via NF-kappaB analog Relish.
Title: The role of peroxiredoxin 4 in inflammatory response and aging.
The effects on fly survival and homeostasis appear to represent a combination of differential effects dictated in large part by dPrx4 subcellular and tissue-specific localization.[peroxiredoxin 4]
Title: The effect of peroxiredoxin 4 on fly physiology is a complex interplay of antioxidant and signaling functions.
an IAP antagonist that promotes cell death by liberating Dronc from DIAP1
Title: Jafrac2 is an IAP antagonist that promotes cell death by liberating Dronc from DIAP1.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables peroxiredoxin activity	IDA Inferred from Direct Assay more info	PubMed
enables peroxiredoxin activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables thioredoxin peroxidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables thioredoxin-dependent peroxiredoxin activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in apoptotic signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in apoptotic signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell redox homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to cold	IDA Inferred from Direct Assay more info	PubMed
involved_in defense response to bacterium	IDA Inferred from Direct Assay more info	PubMed
involved_in hydrogen peroxide catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in hydrogen peroxide catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of receptor signaling pathway via JAK-STAT	IGI Inferred from Genetic Interaction more info	PubMed
involved_in response to oxidative stress	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to oxidative stress	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in endomembrane system	HDA more info	PubMed
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: peroxiredoxin 4

Names: CG1274-PA; CG1274-PB; CG1274-PC; Prx4-PA; Prx4-PB; Prx4-PC; jafrac2; peroxiredoxin 4156; thioredoxin peroxidase; thioredoxin peroxidase 2

NP_001261350.1

EC 1.-.-.-

EC 1.11.1.24

NP_525002.1

EC 1.-.-.-

EC 1.11.1.24

NP_728793.1

EC 1.-.-.-

EC 1.11.1.24

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

3042359..3044174

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_080263.4 → NP_525002.1 peroxiredoxin 4, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_525002.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9V3Q4

Related

FBpp0072852

Conserved Domains (1) summary

cd03015
Location:52 → 223

PRX_Typ2cys; Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides. ...
NM_167971.2 → NP_728793.1 peroxiredoxin 4, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_728793.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9V3Q4

Related

FBpp0072853

Conserved Domains (1) summary

cd03015
Location:52 → 223

PRX_Typ2cys; Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides. ...
NM_001274421.1 → NP_001261350.1 peroxiredoxin 4, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001261350.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9V3Q4

Conserved Domains (1) summary

cd03015
Location:52 → 223

PRX_Typ2cys; Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides. ...