larp La related protein [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: larpprovided by FlyBase
Official Full Name: La related proteinprovided by FlyBase
Primary source: FLYBASE:FBgn0261618
Locus tag: Dmel_CG42551
See related: AllianceGenome:FB:FBgn0261618
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 0031/08; 0225/29; BcDNA:LD02611; CG14065; CG14066; CG42551; dlarp; Dmel\CG42551; l(3)S003108; l(3)S022529; Larp; larp1
Old locus tag: Dmel_CG14065; Dmel_CG14066
Summary: Enables mRNA 5'-UTR binding activity and poly-pyrimidine tract binding activity. Involved in several processes, including mitochondrion inheritance; positive regulation of mitochondrial DNA replication; and regulation of cytoplasmic translation. Located in cytosol. Is extrinsic component of mitochondrial outer membrane. Colocalizes with mitochondrion. Is expressed in several structures, including adult brain; embryonic/larval midgut primordium; germ layer; germline cell; and synaptic neuropil domain. Orthologous to several human genes including LARP1 (La ribonucleoprotein 1, translational regulator). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 98C3-98C4; 3-95 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (28318162..28336440, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (24143884..24162162, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Larp4B is a member of La-related proteins (LARPs) containing an LA motif and an adjacent RNA recognition motif (RRM), and play diverse roles in RNA metabolism. Overexpression of La-related protein 4B (larp4B) reduces cell and organ sizes in Drosophila.
Title: Overexpression of Larp4B downregulates dMyc and reduces cell and organ sizes in Drosophila.
the syncytial mitotic cycles and male meiosis should have a particularly sensitive requirement for Larp proteins in regulating not only transcript stability but also potentially the translation of mRNAs
Title: Drosophila Larp associates with poly(A)-binding protein and is required for male fertility and syncytial embryo development.
The larp mutant males exhibited multiple meiotic phenotypes such as defects in chromosome segregation, a failure of cytokinesis, and unequal mitochondrial partition
Title: A Drosophila orthologue of larp protein family is required for multiple processes in male meiosis.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA cap binding	IEA Inferred from Electronic Annotation more info
enables mRNA 5'-UTR binding	IDA Inferred from Direct Assay more info	PubMed
enables poly-pyrimidine tract binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in mRNA stabilization	IEA Inferred from Electronic Annotation more info
involved_in male meiotic nuclear division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitochondrion inheritance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cytoplasmic translation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cytoplasmic translation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of mitochondrial DNA replication	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of positive regulation of protein targeting to mitochondrion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of translation	IBA Inferred from Biological aspect of Ancestor more info
involved_in spindle assembly involved in male meiosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in syncytial blastoderm mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasmic stress granule	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	HDA more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
is_active_in extrinsic component of mitochondrial outer membrane	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with mitochondrion	HDA more info	PubMed
colocalizes_with mitochondrion	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: La related protein

Names: CG42551-PA; CG42551-PB; CG42551-PD; CG42551-PE; CG42551-PF; CG42551-PG; CG42551-PH; La-related protein; drosophila La related protein; larp; larp-PA; larp-PB; larp-PD; larp-PE; larp-PF; larp-PG; larp-PH; lethal (3) S003108; lethal (3) S022529; meteor

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

28318162..28336440 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_170365.4 → NP_733244.5 La related protein, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_733244.5

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V3J4, D0IQE9, E1JJ02, Q8IMM4, Q8MSZ4, Q8MYR3, Q9NHN6, Q9VAW4, Q9VAW5

UniProtKB/TrEMBL

A0A0B4K7Y7

Conserved Domains (2) summary

smart00684
Location:1383 → 1421

DM15; Tandem repeat in fly CG14066 (La related protein), human KIAA0731 and worm R144.7. Unknown function

cd08034
Location:730 → 803

LARP_1_2; La RNA-binding domain proteins similar to La-related proteins 1 and 2
NM_001260418.2 → NP_001247347.1 La related protein, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001247347.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V3J4, D0IQE9, E1JJ02, Q8IMM4, Q8MSZ4, Q8MYR3, Q9NHN6, Q9VAW4, Q9VAW5

UniProtKB/TrEMBL

A0A0B4K7Y7

Conserved Domains (2) summary

smart00684
Location:1383 → 1421

DM15; Tandem repeat in fly CG14066 (La related protein), human KIAA0731 and worm R144.7. Unknown function

cd08034
Location:730 → 803

LARP_1_2; La RNA-binding domain proteins similar to La-related proteins 1 and 2
NM_001260419.2 → NP_001247348.1 La related protein, isoform H [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001247348.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V3J4, D0IQE9, E1JJ02, Q8IMM4, Q8MSZ4, Q8MYR3, Q9NHN6, Q9VAW4, Q9VAW5

UniProtKB/TrEMBL

A0A0B4K7Y7

Conserved Domains (2) summary

smart00684
Location:1383 → 1421

DM15; Tandem repeat in fly CG14066 (La related protein), human KIAA0731 and worm R144.7. Unknown function

cd08034
Location:730 → 803

LARP_1_2; La RNA-binding domain proteins similar to La-related proteins 1 and 2
NM_001260417.2 → NP_001247346.1 La related protein, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001247346.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4K6K9

Conserved Domains (2) summary

smart00684
Location:1119 → 1157

DM15; Tandem repeat in fly CG14066 (La related protein), human KIAA0731 and worm R144.7. Unknown function

cd08034
Location:466 → 539

LARP_1_2; La RNA-binding domain proteins similar to La-related proteins 1 and 2
NM_170366.4 → NP_733245.1 La related protein, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_733245.1

Status: REVIEWED

UniProtKB/TrEMBL

F9W325, F9W345

Related

FBpp0088624

Conserved Domains (2) summary

smart00684
Location:675 → 713

DM15; Tandem repeat in fly CG14066 (La related protein), human KIAA0731 and worm R144.7. Unknown function

cd08034
Location:22 → 95

LARP_1_2; La RNA-binding domain proteins similar to La-related proteins 1 and 2
NM_080259.3 → NP_524998.1 La related protein, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_524998.1

Status: REVIEWED

UniProtKB/TrEMBL

F9W325, F9W345

Related

FBpp0088622

Conserved Domains (2) summary

smart00684
Location:675 → 713

DM15; Tandem repeat in fly CG14066 (La related protein), human KIAA0731 and worm R144.7. Unknown function

cd08034
Location:22 → 95

LARP_1_2; La RNA-binding domain proteins similar to La-related proteins 1 and 2
NM_001170286.3 → NP_001163757.1 La related protein, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001163757.1

Status: REVIEWED

UniProtKB/TrEMBL

F9W325, F9W345

Conserved Domains (2) summary

smart00684
Location:675 → 713

DM15; Tandem repeat in fly CG14066 (La related protein), human KIAA0731 and worm R144.7. Unknown function

cd08034
Location:22 → 95

LARP_1_2; La RNA-binding domain proteins similar to La-related proteins 1 and 2