U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

bor belphegor [ Drosophila melanogaster (fruit fly) ]

Gene ID: 53565, updated on 4-Jan-2025

Summary

Go to the top of the page Help
Official Symbol
borprovided by FlyBase
Official Full Name
belphegorprovided by FlyBase
Primary source
FLYBASE:FBgn0287225
Locus tag
Dmel_CG6815
See related
AllianceGenome:FB:FBgn0287225
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
ATAD3A; Bor; CG6815; CP89BC; dAtad3a; dATAD3A; denuded; Dmel\CG6815
Summary
Predicted to enable ATP hydrolysis activity. Involved in mitochondrion organization. Located in mitochondrion. Is expressed in adult head. Used to study Harel-Yoon syndrome. Human ortholog(s) of this gene implicated in Harel-Yoon syndrome and neonatal lethal pontocerebellar hypoplasia, hypotonia, and respiratory insufficiency syndrome. Orthologous to several human genes including ATAD3A (ATPase family AAA domain containing 3A). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See bor in Genome Data Viewer
Location:
89B9-89B9; 3-58 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (16261355..16264115, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (12087077..12089837, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45643 Neighboring gene taranis Neighboring gene asunder Neighboring gene Mst89B Neighboring gene Maternal transcript 89Ba

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Elevated cholesterol in ATAD3 mutants is a compensatory mechanism that leads to membrane cholesterol aggregation. Muñoz-Oreja M, et al. Brain, 2024 May 3. PMID 38242545, Free PMC Article
  2. The AAA+ ATPase ATAD3A controls mitochondrial dynamics at the interface of the inner and outer membranes. Gilquin B, et al. Mol Cell Biol, 2010 Apr. PMID 20154147, Free PMC Article
  3. Recurrent De Novo and Biallelic Variation of ATAD3A, Encoding a Mitochondrial Membrane Protein, Results in Distinct Neurological Syndromes. Harel T, et al. Am J Hum Genet, 2016 Oct 6. PMID 27640307, Free PMC Article
  4. Functional interpretation of ATAD3A variants in neuro-mitochondrial phenotypes. Yap ZY, et al. Genome Med, 2021 Apr 12. PMID 33845882, Free PMC Article
  5. The regulation of cell size and branch complexity in the terminal cells of the Drosophila tracheal system. Burguete AS, et al. Dev Biol, 2019 Jul 1. PMID 30735663, Free PMC Article

See all (58) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity ISM
Inferred from Sequence Model
more info
 PubMed 
Process Evidence Code Pubs
involved_in mitochondrion organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrion organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in mitochondrial inner membrane ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
belphegor
Names
CG6815-PA
CG6815-PB
bor-PA
bor-PB
cytoplasmic protein 89BC
denuded

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    16261355..16264115 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001260206.1 → NP_001247135.1  belphegor, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001247135.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VEX6
    UniProtKB/TrEMBL
    Q7KJ37
    Conserved Domains (3) summary
    pfam00004
    Location:354 → 481
    AAA; ATPase family associated with various cellular activities (AAA)
    pfam12037
    Location:34 → 291
    DUF3523; Domain of unknown function (DUF3523)
    cl28319
    Location:326 → 373
    COG1855; Predicted ATPase, PilT family [General function prediction only]

  2. NM_080257.4 → NP_524996.1  belphegor, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524996.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VEX6
    UniProtKB/TrEMBL
    Q7KJ37
    Related
    FBpp0082728
    Conserved Domains (3) summary
    pfam00004
    Location:354 → 481
    AAA; ATPase family associated with various cellular activities (AAA)
    pfam12037
    Location:34 → 291
    DUF3523; Domain of unknown function (DUF3523)
    cl28319
    Location:326 → 373
    COG1855; Predicted ATPase, PilT family [General function prediction only]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7KJ37 Q7KJ37
Q95TQ1 Q95TQ1
Q9VEX6.2 Q9VEX6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools
Miscellaneous