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lectin-46Ca lectin-46Ca [ Drosophila melanogaster (fruit fly) ]

Gene ID: 53523, updated on 9-Dec-2024

Summary

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Official Symbol
lectin-46Caprovided by FlyBase
Official Full Name
lectin-46Caprovided by FlyBase
Primary source
FLYBASE:FBgn0040093
Locus tag
Dmel_CG1656
See related
AllianceGenome:FB:FBgn0040093
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
AC 007330A; AC007330a; CG1656; Dmel\CG1656; Lectin-46Ca; Lectin-46CA
Summary
Predicted to enable galactose binding activity. Involved in protein localization; regulation of female receptivity, post-mating; and sperm competition. Located in cell surface. Is expressed in several structures, including adult head; female reproductive system; oviduct; sperm storage organ; and uterus. Human ortholog(s) of this gene implicated in Coronavirus infectious disease; aspergillosis; dengue disease (multiple); human immunodeficiency virus infectious disease (multiple); and tuberculosis (multiple). Orthologous to human CLEC4F (C-type lectin domain family 4 member F) and CD209 (CD209 molecule). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See lectin-46Ca in Genome Data Viewer
Location:
46B4-46B4; 2-61 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (9817300..9818535)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (5704805..5706040)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene lectin-46Cb Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene dilatory

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Post-mating change in excretion by mated Drosophila melanogaster females is a long-term response that depends on sex peptide and sperm. Apger-McGlaughon J, et al. J Insect Physiol, 2013 Oct. PMID 23891750, Free PMC Article
  2. Sex peptide is required for the efficient release of stored sperm in mated Drosophila females. Avila FW, et al. Genetics, 2010 Oct. PMID 20679516, Free PMC Article
  3. The lncRNA male-specific abdominal plays a critical role in Drosophila accessory gland development and male fertility. Maeda RK, et al. PLoS Genet, 2018 Jul. PMID 30011265, Free PMC Article
  4. A network of interactions among seminal proteins underlies the long-term postmating response in Drosophila. Ram KR, et al. Proc Natl Acad Sci U S A, 2009 Sep 8. PMID 19706411, Free PMC Article
  5. Acp36DE is required for uterine conformational changes in mated Drosophila females. Avila FW, et al. Proc Natl Acad Sci U S A, 2009 Sep 15. PMID 19805225, Free PMC Article

See all (54) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables carbohydrate binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables galactose binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of female receptivity, post-mating IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sexual reproduction HEP PubMed 
involved_in sperm competition IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cell surface IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular space HDA PubMed 
located_in extracellular space ISM
Inferred from Sequence Model
more info
 PubMed 

General protein information

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Preferred Names
lectin-46Ca
Names
CG1656-PA
lectin-44Ca
lectin-46Ca-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    9817300..9818535
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_144376.2 → NP_652633.1  lectin-46Ca [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_652633.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1Z7Z6, Q8MR48
    Related
    FBpp0087560, FBtr0088476
    Conserved Domains (1) summary
    cd00037
    Location:43 → 162
    CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A1Z7Z6 A1Z7Z6
Q8MR48 Q8MR48

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