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Ugt35E2 UDP-glycosyltransferase family 35 member E2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 53506, updated on 17-Dec-2024

Summary

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Official Symbol
Ugt35E2provided by FlyBase
Official Full Name
UDP-glycosyltransferase family 35 member E2provided by FlyBase
Primary source
FLYBASE:FBgn0040255
Locus tag
Dmel_CG6653
See related
AllianceGenome:FB:FBgn0040255
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
AC 006491E; CG6653; CG6653-PA; Dmel\CG6653; UGT35E2; Ugt86De; Ugt86DE
Summary
Predicted to enable UDP-glycosyltransferase activity. Predicted to be involved in glycosylation. Predicted to be active in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in several diseases, including alcoholic pancreatitis; bilirubin metabolic disorder (multiple); cholecystolithiasis; cholelithiasis; and female reproductive organ cancer (multiple). Orthologous to several human genes including UGT1A1 (UDP glucuronosyltransferase family 1 member A1); UGT1A10 (UDP glucuronosyltransferase family 1 member A10); and UGT1A3 (UDP glucuronosyltransferase family 1 member A3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See Ugt35E2 in Genome Data Viewer
Location:
86D5-86D5; 3-50 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (11166177..11167981, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (6991899..6993703, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene UDP-glycosyltransferase family 35 member E1 Neighboring gene UDP-glycosyltransferase family 35 member B1 Neighboring gene UDP-glycosyltransferase family 35 member A1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Fine-mapping nicotine resistance loci in Drosophila using a multiparent advanced generation inter-cross population. Marriage TN, et al. Genetics, 2014 Sep. PMID 25236448, Free PMC Article
  2. Drosophila P elements preferentially transpose to replication origins. Spradling AC, et al. Proc Natl Acad Sci U S A, 2011 Sep 20. PMID 21896744, Free PMC Article
  3. Insect glycobiology: a lectin multigene family in Drosophila melanogaster. Theopold U, et al. Biochem Biophys Res Commun, 1999 Aug 11. PMID 10441526
  4. The UDP-Glycosyltransferase Family in Drosophila melanogaster: Nomenclature Update, Gene Expression and Phylogenetic Analysis. Ahn SJ, et al. Front Physiol, 2021. PMID 33815151, Free PMC Article
  5. A sexually transmitted sugar orchestrates reproductive responses to nutritional stress. Kim SJ, et al. Nat Commun, 2024 Oct 1. PMID 39353950, Free PMC Article

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables UDP-glycosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables UDP-glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables UDP-glycosyltransferase activity ISM
Inferred from Sequence Model
more info
 PubMed 
Process Evidence Code Pubs
involved_in glycosylation ISM
Inferred from Sequence Model
more info
 PubMed 
Component Evidence Code Pubs
is_active_in endoplasmic reticulum membrane ISM
Inferred from Sequence Model
more info
 PubMed 

General protein information

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Preferred Names
UDP-glycosyltransferase family 35 member E2
Names
CG6653-PA
UDP-glycosyltransferase 86De
Ugt35E2-PA
Ugt86De

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    11166177..11167981 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_144366.4 → NP_652623.2  UDP-glycosyltransferase family 35 member E2 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_652623.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VGT1
    Related
    FBpp0081852
    Conserved Domains (2) summary
    PHA03392
    Location:23 → 481
    egt; ecdysteroid UDP-glucosyltransferase; Provisional
    COG1819
    Location:26 → 440
    YjiC; UDP:flavonoid glycosyltransferase YjiC, YdhE family [Carbohydrate transport and metabolism]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8SZE2 Q8SZE2
Q9VGT1 Q9VGT1

Gene LinkOut

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