Alk Anaplastic lymphoma kinase [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Alkprovided by FlyBase
Official Full Name: Anaplastic lymphoma kinaseprovided by FlyBase
Primary source: FLYBASE:FBgn0040505
Locus tag: Dmel_CG8250
See related: AllianceGenome:FB:FBgn0040505
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: alk; ALK; CG8250; dAlk; dALK; DAlk; DAlk53; Dmel\CG8250; mili
Summary: Enables transmembrane receptor protein tyrosine kinase activity. Involved in several processes, including negative regulation of cell size; negative regulation of neuromuscular synaptic transmission; and neuron development. Located in subsynaptic reticulum; type Ib terminal bouton; and type Is terminal bouton. Is active in neuromuscular junction and postsynapse. Is expressed in several structures, including adult brain; ganglia; myoblast; synaptic neuropil domain; and synaptic neuropil subdomain. Used to study cancer and neuroblastoma. Orthologous to several human genes including ALK (ALK receptor tyrosine kinase). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: 53C12-53C13; 2-80 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (16625293..16640011, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (12512798..12527516, complement)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Alk receptor tyrosine kinase regulates Sparkly, a novel activity regulating neuropeptide precursor in the Drosophila central nervous system.
Title: The Alk receptor tyrosine kinase regulates Sparkly, a novel activity regulating neuropeptide precursor in the Drosophila central nervous system.
Patient-associated mutations in Drosophila Alk perturb neuronal differentiation and promote survival.
Title: Patient-associated mutations in Drosophila Alk perturb neuronal differentiation and promote survival.
DamID transcriptional profiling identifies the Snail/Scratch transcription factor Kahuli as an Alk target in the Drosophila visceral mesoderm.
Title: DamID transcriptional profiling identifies the Snail/Scratch transcription factor Kahuli as an Alk target in the Drosophila visceral mesoderm.
The neuronal receptor tyrosine kinase Alk is a target for longevity.
Title: The neuronal receptor tyrosine kinase Alk is a target for longevity.
Identification of the Wallenda JNKKK as an Alk suppressor reveals increased competitiveness of Alk-expressing cells.
Title: Identification of the Wallenda JNKKK as an Alk suppressor reveals increased competitiveness of Alk-expressing cells.
Opa protein is a novel regulator of embryonic Alk expression.
Title: The Zic family homologue Odd-paired regulates Alk expression in Drosophila.
mutations in Nf1 produce a sexually dimorphic short sleep phenotype, and suppress the long sleep phenotype of Alk. Thus Alk and Nf1 interact in both learning and sleep regulation, highlighting a common pathway in these two processes
Title: Anaplastic Lymphoma Kinase Acts in the Drosophila Mushroom Body to Negatively Regulate Sleep.
This study demonistrated that Signaling through the anaplastic lymphoma kinase directly regulates neuronal survival in visual pathway.
Title: Sequential axon-derived signals couple target survival and layer specificity in the Drosophila visual system.
Role of Lmd transcription factor in visceral mesoderm development in relationship to Jeb/Alk signal transduction. Alk signalling negatively regulates Lmd activity through the MAPK cascade resulting in a relocalisation of Lmd from nucleus to cytoplasm.
Title: Jeb/Alk signalling regulates the Lame duck GLI family transcription factor in the Drosophila visceral mesoderm.
These results identify dAlk as an upstream activator of dNf1-regulated Ras signaling responsible for several dNf1 defects, and they implicate human Alk as a potential therapeutic target in NF1
Title: The receptor tyrosine kinase Alk controls neurofibromin functions in Drosophila growth and learning.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dm0813 (e-PCR)
- UniSTS:36380

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transmembrane receptor protein tyrosine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane receptor protein tyrosine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables transmembrane receptor protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in compound eye photoreceptor development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in digestive tract development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mesoderm development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in multicellular organism development	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of cell size	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of neuromuscular synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of ERK1 and ERK2 cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of MAPK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of neuron differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of olfactory learning	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in trans-synaptic signaling by neuropeptide	IDA Inferred from Direct Assay more info	PubMed
involved_in trans-synaptic signaling by neuropeptide	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in visceral muscle development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in neuromuscular junction	IDA Inferred from Direct Assay more info	PubMed
is_active_in neuromuscular junction	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in postsynapse	IDA Inferred from Direct Assay more info	PubMed
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info
located_in subsynaptic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in type Ib terminal bouton	IDA Inferred from Direct Assay more info	PubMed
located_in type Is terminal bouton	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: anaplastic lymphoma kinase

Names: Alk-PA; Alk-PB; CG8250-PA; CG8250-PB

NP_001261027.1

EC 2.7.10.1

NP_652600.1

EC 2.7.10.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

16625293..16640011 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001274098.1 → NP_001261027.1 anaplastic lymphoma kinase, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001261027.1

Status: REVIEWED

UniProtKB/TrEMBL

Q7KJ08

Conserved Domains (4) summary

cd06263
Location:505 → 689

MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...

smart00219
Location:1193 → 1460

TyrKc; Tyrosine kinase, catalytic domain

cd05036
Location:1186 → 1462

PTKc_ALK_LTK; Catalytic domain of the Protein Tyrosine Kinases, Anaplastic Lymphoma Kinase and Leukocyte Tyrosine Kinase

pfam00629
Location:505 → 691

MAM; MAM domain, meprin/A5/mu
NM_144343.3 → NP_652600.1 anaplastic lymphoma kinase, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_652600.1

Status: REVIEWED

UniProtKB/TrEMBL

Q7KJ08

Related

FBpp0086264

Conserved Domains (4) summary

cd06263
Location:505 → 689

MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...

smart00219
Location:1193 → 1460

TyrKc; Tyrosine kinase, catalytic domain

cd05036
Location:1186 → 1462

PTKc_ALK_LTK; Catalytic domain of the Protein Tyrosine Kinases, Anaplastic Lymphoma Kinase and Leukocyte Tyrosine Kinase

pfam00629
Location:505 → 691

MAM; MAM domain, meprin/A5/mu