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IL17D interleukin 17D [ Homo sapiens (human) ]

Gene ID: 53342, updated on 27-Nov-2024

Summary

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Official Symbol
IL17Dprovided by HGNC
Official Full Name
interleukin 17Dprovided by HGNC
Primary source
HGNC:HGNC:5984
See related
Ensembl:ENSG00000172458 MIM:607587; AllianceGenome:HGNC:5984
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IL-17D
Summary
The protein encoded by this gene is a cytokine that shares the sequence similarity with IL17. The treatment of endothelial cells with this cytokine has been shown to stimulate the production of other cytokines including IL6, IL8 and CSF2/ GM-CSF. The increased expression of IL8 induced by this cytokine was found to be NF-kappa B-dependent. [provided by RefSeq, Jul 2008]
Expression
Biased expression in brain (RPKM 13.7), ovary (RPKM 2.3) and 11 other tissues See more
Orthologs
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Genomic context

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See IL17D in Genome Data Viewer
Location:
13q12.11
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (20701513..20723098)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (19894661..19916241)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (21275652..21297237)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene intraflagellar transport 88 Neighboring gene solute carrier family 35 member E1 pseudogene 1 Neighboring gene RNA, U2 small nuclear 7, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5155 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5156 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5157 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr13:21290864-21291578 Neighboring gene Sharpr-MPRA regulatory region 1468 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:21303728-21304255 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:21304256-21304782 Neighboring gene EEF1A lysine methyltransferase 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7426 Neighboring gene RAN pseudogene 8 Neighboring gene exportin 4 Neighboring gene uncharacterized LOC124903129

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Interleukin-17D promotes lung cancer progression by inducing tumor-associated macrophage infiltration via the p38 MAPK signaling pathway. Lin Z, et al. Aging (Albany NY), 2022 Aug 5. PMID 35939336, Free PMC Article
  2. Nuclear factor erythroid 2-related factor 2 potentiates the generation of inflammatory cytokines by intestinal epithelial cells during hyperoxia by inducing the expression of interleukin 17D. Liu X, et al. Toxicology, 2021 Jun 15. PMID 34023435
  3. Interleukin-17D mediates tumor rejection through recruitment of natural killer cells. O'Sullivan T, et al. Cell Rep, 2014 May 22. PMID 24794441, Free PMC Article
  4. Interleukin-17D produced by alveolar epithelial type II cells alleviates LPS-induced acute lung injury via the Nrf2 pathway. Dong S, et al. Clin Sci (Lond), 2023 Sep 27. PMID 37708335
  5. Cutting edge: IL-17D, a novel member of the IL-17 family, stimulates cytokine production and inhibits hemopoiesis. Starnes T, et al. J Immunol, 2002 Jul 15. PMID 12097364

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Interleukin-17D produced by alveolar epithelial type II cells alleviates LPS-induced acute lung injury via the Nrf2 pathway.
    Title: Interleukin-17D produced by alveolar epithelial type II cells alleviates LPS-induced acute lung injury via the Nrf2 pathway.
  2. Interleukin-17D promotes lung cancer progression by inducing tumor-associated macrophage infiltration via the p38 MAPK signaling pathway.
    Title: Interleukin-17D promotes lung cancer progression by inducing tumor-associated macrophage infiltration via the p38 MAPK signaling pathway.
  3. Nuclear factor erythroid 2-related factor 2 potentiates the generation of inflammatory cytokines by intestinal epithelial cells during hyperoxia by inducing the expression of interleukin 17D.
    Title: Nuclear factor erythroid 2-related factor 2 potentiates the generation of inflammatory cytokines by intestinal epithelial cells during hyperoxia by inducing the expression of interleukin 17D.
  4. Nrf2 Induces IL-17D to mediate tumor and virus surveillance.
    Title: Nrf2 Induces IL-17D to Mediate Tumor and Virus Surveillance.
  5. Study of the expression of IL-17 provides theoretical support for the clinical treatment and prognosis prediction of ovarian epithelial tumor.
    Title: Expression of inflammatory cytokines in ovarian epithelial cancer and their correlation.
  6. Utilizing gene microarray analysis, authors found the cytokine interleukin 17D (IL-17D) was highly expressed in certain unedited tumors.
    Title: Interleukin-17D mediates tumor rejection through recruitment of natural killer cells.
  7. These experiments were designed to investigate the effects of IL-17 upon the phenotype and function of human Natural Killer (NK) cells.
    Title: The effects of IL-17 upon human natural killer cells.
  8. IL-27 priming results in enhanced lipopolysaccharide-induced IL-6, tumor necrosis factor (TNF)-alpha, macrophage inflammatory protein (MIP)-1alpha, and MIP-1beta expression in human primary monocytes.
    Title: IL-27 enhances LPS-induced proinflammatory cytokine production via upregulation of TLR4 expression and signaling in human monocytes.
  9. Observational study of gene-disease association. (HuGE Navigator)
    Title: New genetic associations detected in a host response study to hepatitis B vaccine.
  10. IL-17D stimulates production of cytokines in endothelial cells in vitro and suppresses proliferation of myeloid progenitors in colony formation assays.
    Title: Cutting edge: IL-17D, a novel member of the IL-17 family, stimulates cytokine production and inhibits hemopoiesis.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genetic determinants of P wave duration and PR segment.
EBI GWAS Catalog
GWAS of dental caries patterns in the permanent dentition.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ30846

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cytokine activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables receptor ligand activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in inflammatory response IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of hemopoiesis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of cytokine production involved in inflammatory response IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of granulocyte macrophage colony-stimulating factor production IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of interleukin-6 production IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of interleukin-8 production IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
interleukin-17D

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001385221.1 → NP_001372150.1  interleukin-17D isoform a precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a). Isoforms a and b are the same length but differ in their N-termini.
    Source sequence(s)
    AL161772, AL512652
    Conserved Domains (1) summary
    pfam06083
    Location:96 → 177
    IL17; Interleukin-17

  2. NM_001385222.1 → NP_001372151.1  interleukin-17D isoform b precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) encodes the longest isoform (b). Isoforms a and b are the same length but differ in their N-termini.
    Source sequence(s)
    AL161772, AL512652
    Conserved Domains (1) summary
    pfam06083
    Location:96 → 177
    IL17; Interleukin-17

  3. NM_001385223.1 → NP_001372152.1  interleukin-17D isoform c precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4), as well as variants 3 and 5, encodes isoform c.
    Source sequence(s)
    AL161772, AL512652
    Consensus CDS
    CCDS9292.1
    UniProtKB/Swiss-Prot
    B1AM69, Q8TAD2
    Conserved Domains (1) summary
    pfam06083
    Location:89 → 170
    IL17; Interleukin-17

  4. NM_001385224.1 → NP_001372153.1  interleukin-17D isoform c precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5), as well as variants 3 and 4, encodes isoform c.
    Source sequence(s)
    AL161772, AL512652
    Consensus CDS
    CCDS9292.1
    UniProtKB/Swiss-Prot
    B1AM69, Q8TAD2
    Related
    ENSP00000508385.1, ENST00000682841.1
    Conserved Domains (1) summary
    pfam06083
    Location:89 → 170
    IL17; Interleukin-17

  5. NM_001385225.1 → NP_001372154.1  interleukin-17D isoform d

    Status: REVIEWED

    Source sequence(s)
    AL161772, AL512652
    Conserved Domains (1) summary
    pfam06083
    Location:11 → 86
    IL17; Interleukin-17

  6. NM_001386973.1 → NP_001373902.1  interleukin-17D isoform e

    Status: REVIEWED

    Source sequence(s)
    AL512652
    Conserved Domains (1) summary
    pfam06083
    Location:9 → 82
    IL17; Interleukin-17

  7. NM_138284.2 → NP_612141.1  interleukin-17D isoform c precursor

    See identical proteins and their annotated locations for NP_612141.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3), as well as variants 4 and 5, encodes isoform c.
    Source sequence(s)
    AL161772, AL512652
    Consensus CDS
    CCDS9292.1
    UniProtKB/Swiss-Prot
    B1AM69, Q8TAD2
    Related
    ENSP00000302924.3, ENST00000304920.3
    Conserved Domains (1) summary
    pfam06083
    Location:89 → 170
    IL17; Interleukin-17

RNA

  1. NR_169590.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL161772, AL512652

  2. NR_169591.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL161772, AL512652

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

    Range
    20701513..20723098
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060937.1 Alternate T2T-CHM13v2.0

    Range
    19894661..19916241
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8TAD2.1 GenPept UniProtKB/Swiss-Prot:Q8TAD2

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