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Ldhd lactate dehydrogenase D [ Mus musculus (house mouse) ]

Gene ID: 52815, updated on 27-Nov-2024

Summary

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Official Symbol
Ldhdprovided by MGI
Official Full Name
lactate dehydrogenase Dprovided by MGI
Primary source
MGI:MGI:106428
See related
Ensembl:ENSMUSG00000031958 AllianceGenome:MGI:106428
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
DLD; D8Bwg1320e; 4733401P21Rik
Summary
Predicted to enable D-lactate dehydrogenase (cytochrome) activity; D-lactate dehydrogenase activity; and flavin adenine dinucleotide binding activity. Predicted to be involved in lactate catabolic process. Located in mitochondrion. Orthologous to human LDHD (lactate dehydrogenase D). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in genital fat pad adult (RPKM 169.0), kidney adult (RPKM 153.8) and 7 other tissues See more
Orthologs
human all
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Genomic context

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See Ldhd in Genome Data Viewer
Location:
8 E1; 8 57.98 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (112352250..112356968, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (111625611..111630336, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_22695 Neighboring gene predicted gene, 24793 Neighboring gene WD repeat domain 59 Neighboring gene STARR-positive B cell enhancer ABC_E112 Neighboring gene STARR-seq mESC enhancer starr_22698 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:114079308-114079417 Neighboring gene STARR-positive B cell enhancer ABC_E5041 Neighboring gene zinc and ring finger 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:114087696-114087913 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:114116137-114116338 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:114119771-114119993 Neighboring gene STARR-seq mESC enhancer starr_22705 Neighboring gene STARR-positive B cell enhancer ABC_E9323 Neighboring gene STARR-positive B cell enhancer ABC_E885 Neighboring gene STARR-positive B cell enhancer ABC_E5042 Neighboring gene STARR-seq mESC enhancer starr_22707 Neighboring gene STARR-seq mESC enhancer starr_22708 Neighboring gene zinc finger protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E10523 Neighboring gene microRNA 7076 Neighboring gene chymotrypsinogen B1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Hyperuricemia and gout caused by missense mutation in d-lactate dehydrogenase. Drabkin M, et al. J Clin Invest, 2019 Dec 2. PMID 31638601, Free PMC Article
  2. Structure of the murine E-selectin ligand 1 (ESL-1) gene and assignment to Chromosome 8. Willmroth F, et al. Mamm Genome, 1999 Nov. PMID 10556428
  3. Identification of putative mammalian D-lactate dehydrogenase enzymes. Flick MJ, et al. Biochem Biophys Res Commun, 2002 Jul 26. PMID 12127981
  4. Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis. Brady KP, et al. Genome Res, 1997 Nov. PMID 9371744, Free PMC Article
  5. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, et al. Cell, 2003 Nov 26. PMID 14651853

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables D-lactate dehydrogenase (cytochrome) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables D-lactate dehydrogenase (cytochrome) activity IEA
Inferred from Electronic Annotation
more info
  
enables D-lactate dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables D-lactate dehydrogenase activity NAS
Non-traceable Author Statement
more info
 PubMed 
enables FAD binding IEA
Inferred from Electronic Annotation
more info
  
enables flavin adenine dinucleotide binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in ATP biosynthetic process NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in lactate catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in lactate catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in lactate catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
probable D-lactate dehydrogenase, mitochondrial
NP_081846.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_027570.5 → NP_081846.3  probable D-lactate dehydrogenase, mitochondrial

    See identical proteins and their annotated locations for NP_081846.3

    Status: VALIDATED

    Source sequence(s)
    AC122364
    Consensus CDS
    CCDS22677.1
    UniProtKB/Swiss-Prot
    Q7TNG8, Q8BYU7, Q8CIV4
    UniProtKB/TrEMBL
    Q9D635
    Related
    ENSMUSP00000068086.4, ENSMUST00000070004.4
    Conserved Domains (3) summary
    COG0277
    Location:34 → 484
    GlcD; FAD/FMN-containing dehydrogenase [Energy production and conversion]
    pfam01565
    Location:66 → 202
    FAD_binding_4; FAD binding domain
    pfam02913
    Location:243 → 483
    FAD-oxidase_C; FAD linked oxidases, C-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    112352250..112356968 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7TNG8.1 GenPept UniProtKB/Swiss-Prot:Q7TNG8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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