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Tet1 tet methylcytosine dioxygenase 1 [ Mus musculus (house mouse) ]

Gene ID: 52463, updated on 27-Nov-2024

Summary

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Official Symbol
Tet1provided by MGI
Official Full Name
tet methylcytosine dioxygenase 1provided by MGI
Primary source
MGI:MGI:1098693
See related
Ensembl:ENSMUSG00000047146 AllianceGenome:MGI:1098693
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
LCX; Cxxc6; mKIAA1676; D10Ertd17e; 2510010B09Rik
Summary
Enables 5-methylcytosine dioxygenase activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including dendrite morphogenesis; inner cell mass cell differentiation; and positive regulation of transcription by RNA polymerase II. Acts upstream of or within epigenetic programing of male pronucleus and positive regulation of gene expression via chromosomal CpG island demethylation. Located in nucleus. Is expressed in several structures, including brain; early conceptus; immune system; lower urogenital tract; and reproductive system. Orthologous to human TET1 (tet methylcytosine dioxygenase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in CNS E18 (RPKM 2.2), whole brain E14.5 (RPKM 2.0) and 18 other tissues See more
Orthologs
human all
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Genomic context

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See Tet1 in Genome Data Viewer
Location:
10 B4; 10 32.48 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (62640349..62723242, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (62804570..62887469, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene storkhead box 1 Neighboring gene NHP2 ribonucleoprotein pseudogene Neighboring gene STARR-seq mESC enhancer starr_26893 Neighboring gene cell division cycle and apoptosis regulator 1 Neighboring gene small nucleolar RNA, C/D box 98 Neighboring gene STARR-seq mESC enhancer starr_26894 Neighboring gene STARR-seq mESC enhancer starr_26901 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:62328128-62328311 Neighboring gene STARR-seq mESC enhancer starr_26907 Neighboring gene predicted gene, 51805 Neighboring gene CRISPRi-validated Tet1 enhancer cluster Neighboring gene predicted gene, 26479 Neighboring gene solute carrier family 25 (mitochondrial carrier, Graves disease autoantigen), member 16 Neighboring gene predicted gene, 25862

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. An epigenetic switch repressing Tet1 in gonadotropes activates the reproductive axis. Yosefzon Y, et al. Proc Natl Acad Sci U S A, 2017 Sep 19. PMID 28855337, Free PMC Article
  2. TET1 regulates gene expression and repression of endogenous retroviruses independent of DNA demethylation. Stolz P, et al. Nucleic Acids Res, 2022 Aug 26. PMID 35904814, Free PMC Article
  3. Loss of Tet1-Associated 5-Hydroxymethylcytosine Is Concomitant with Aberrant Promoter Hypermethylation in Liver Cancer. Thomson JP, et al. Cancer Res, 2016 May 15. PMID 27197233, Free PMC Article
  4. Editing DNA Methylation in the Mammalian Genome. Liu XS, et al. Cell, 2016 Sep 22. PMID 27662091, Free PMC Article
  5. Craniofacial features resembling frontonasal dysplasia with a tubulonodular interhemispheric lipoma in the adult 3H1 tuft mouse. Fong KS, et al. Birth Defects Res A Clin Mol Teratol, 2012 Feb. PMID 22246904, Free PMC Article

See all (237) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Tet1-mediated 5hmC regulates hippocampal neuroinflammation via wnt signaling as a novel mechanism in obstructive sleep apnoea leads to cognitive deficit.
    Title: Tet1-mediated 5hmC regulates hippocampal neuroinflammation via wnt signaling as a novel mechanism in obstructive sleep apnoea leads to cognitive deficit.
  2. TET1 promotes RXRalpha expression and adipogenesis through DNA demethylation.
    Title: TET1 promotes RXRα expression and adipogenesis through DNA demethylation.
  3. TET1 displays catalytic and non-catalytic functions in the adult mouse cortex.
    Title: TET1 displays catalytic and non-catalytic functions in the adult mouse cortex.
  4. TET1 inhibits liver fibrosis by blocking hepatic stellate cell activation.
    Title: TET1 inhibits liver fibrosis by blocking hepatic stellate cell activation.
  5. TET1 Participates in Complete Freund's Adjuvant-induced Trigeminal Inflammatory Pain by Regulating Kv7.2 in a Mouse Model.
    Title: TET1 Participates in Complete Freund's Adjuvant-induced Trigeminal Inflammatory Pain by Regulating Kv7.2 in a Mouse Model.
  6. TET1 mediated m5C modification of RelB aggravates cerebral ischemia/reperfusion-induced neuroinflammation through regulating microglia polarization.
    Title: TET1 mediated m5C modification of RelB aggravates cerebral ischemia/reperfusion-induced neuroinflammation through regulating microglia polarization.
  7. Microbiota regulates the TET1-mediated DNA hydroxymethylation program in innate lymphoid cell differentiation.
    Title: Microbiota regulates the TET1-mediated DNA hydroxymethylation program in innate lymphoid cell differentiation.
  8. Iterative oxidation by TET1 is required for reprogramming of imprinting control regions and patterning of mouse sperm hypomethylated regions.
    Title: Iterative oxidation by TET1 is required for reprogramming of imprinting control regions and patterning of mouse sperm hypomethylated regions.
  9. ZFP281 controls transcriptional and epigenetic changes promoting mouse pluripotent state transitions via DNMT3 and TET1.
    Title: ZFP281 controls transcriptional and epigenetic changes promoting mouse pluripotent state transitions via DNMT3 and TET1.
  10. TET1-mediated epigenetic regulation of tumor necrosis factor-alpha in trigeminal ganglia contributes to chronic temporomandibular joint pain.
    Title: TET1-mediated epigenetic regulation of tumor necrosis factor-α in trigeminal ganglia contributes to chronic temporomandibular joint pain.
Submit: New GeneRIF Correction See all GeneRIFs (142)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 5-methylcytosine dioxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 5-methylcytosine dioxygenase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 5-methylcytosine dioxygenase activity ISO
Inferred from Sequence Orthology
more info
  
enables 5-methylcytosine dioxygenase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables iron ion binding ISO
Inferred from Sequence Orthology
more info
  
enables iron ion binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables methyl-CpG binding ISO
Inferred from Sequence Orthology
more info
  
enables methyl-CpG binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in cellular response to reactive oxygen species IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to reactive oxygen species ISO
Inferred from Sequence Orthology
more info
  
involved_in chromatin remodeling ISO
Inferred from Sequence Orthology
more info
  
involved_in chromatin remodeling ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in chromosomal 5-methylcytosine DNA demethylation, oxidation pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in dendrite morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within epigenetic programing of male pronucleus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within inner cell mass cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in inner cell mass cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of cell migration NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in negative regulation of stem cell population maintenance NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in negative regulation of transforming growth factor beta receptor signaling pathway NAS
Non-traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within positive regulation of gene expression via chromosomal CpG island demethylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of gene expression via chromosomal CpG island demethylation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within positive regulation of gene expression via chromosomal CpG island demethylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of gene expression via chromosomal CpG island demethylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of gene expression via chromosomal CpG island demethylation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of stem cell population maintenance NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in protein O-linked glycosylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in stem cell population maintenance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of Sin3-type complex NAS
Non-traceable Author Statement
more info
 PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
methylcytosine dioxygenase TET1
Names
CXXC finger 6
CXXC-type zinc finger protein 6
ten-eleven translocation 1 gene protein homolog
tet oncogene 1
NP_001240786.1
NP_001393310.1
NP_001393311.1
NP_001393312.1
XP_006513930.1
XP_030101034.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001253857.2 → NP_001240786.1  methylcytosine dioxygenase TET1 isoform 1

    See identical proteins and their annotated locations for NP_001240786.1

    Status: VALIDATED

    Source sequence(s)
    AC166359
    Consensus CDS
    CCDS56706.1
    UniProtKB/Swiss-Prot
    D0VLQ4, E9Q9Y4, Q3URK3, Q6ZPK2, Q9CY36
    UniProtKB/TrEMBL
    A0A9L6H7S7
    Related
    ENSMUSP00000133279.2, ENSMUST00000174189.2
    Conserved Domains (2) summary
    pfam02008
    Location:568 → 607
    zf-CXXC; CXXC zinc finger domain
    pfam12851
    Location:1528 → 1686
    Tet_JBP; Oxygenase domain of the 2OGFeDO superfamily

  2. NM_001406381.1 → NP_001393310.1  methylcytosine dioxygenase TET1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC166359

  3. NM_001406382.1 → NP_001393311.1  methylcytosine dioxygenase TET1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC166359

  4. NM_001406383.1 → NP_001393312.1  methylcytosine dioxygenase TET1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC166359

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    62640349..62723242 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006513867.5 → XP_006513930.1  methylcytosine dioxygenase TET1 isoform X1

    See identical proteins and their annotated locations for XP_006513930.1

    UniProtKB/TrEMBL
    A0A9L6H7S7
    Conserved Domains (2) summary
    pfam02008
    Location:568 → 607
    zf-CXXC; CXXC zinc finger domain
    cl40427
    Location:1371 → 1993
    Tet_JBP; oxygenase domain of ten-eleven translocation (TET) enzymes, J-binding proteins (JBPs), and similar proteins

  2. XM_030245174.2 → XP_030101034.1  methylcytosine dioxygenase TET1 isoform X2

    Conserved Domains (1) summary
    cl40427
    Location:717 → 1339
    Tet_JBP; oxygenase domain of ten-eleven translocation (TET) enzymes, J-binding proteins (JBPs), and similar proteins

RNA

  1. XR_003948738.2 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_027384.1: Suppressed sequence

    Description
    NM_027384.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3URK3.3 GenPept UniProtKB/Swiss-Prot:Q3URK3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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Chemical Information
Molecular Biology Databases
Research Materials
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