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LSR lipolysis stimulated lipoprotein receptor [ Homo sapiens (human) ]

Gene ID: 51599, updated on 27-Nov-2024

Summary

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Official Symbol
LSRprovided by HGNC
Official Full Name
lipolysis stimulated lipoprotein receptorprovided by HGNC
Primary source
HGNC:HGNC:29572
See related
Ensembl:ENSG00000105699 MIM:616582; AllianceGenome:HGNC:29572
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ILDR3; LISCH7
Summary
Predicted to be involved in several processes, including establishment of skin barrier; protein localization to tricellular tight junction; and tricellular tight junction assembly. Located in plasma membrane and tight junction. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in stomach (RPKM 52.0), colon (RPKM 51.5) and 22 other tissues See more
Orthologs
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Genomic context

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See LSR in Genome Data Viewer
Location:
19q13.12
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (35249002..35267964)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (37793654..37812636)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (35739905..35758867)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 187 member B Neighboring gene family with sequence similarity 187, member B pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14461 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:35738792-35739594 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:35739595-35740396 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:35748323-35748823 Neighboring gene uncharacterized LOC105372380 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:35753027-35753725 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14462 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10519 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10520 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10521 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10522 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10523 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:35761221-35761960 Neighboring gene upstream transcription factor 2, c-fos interacting Neighboring gene HNF4 motif-containing MPRA enhancer 344 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14463 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14464 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:35773293-35773802 Neighboring gene hepcidin antimicrobial peptide

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Prognostic value of LISCH7 mRNA in plasma and tumor of colon cancer patients. García JM, et al. Clin Cancer Res, 2007 Nov 1. PMID 17975147
  2. Loss of tricellular tight junction protein LSR promotes cell invasion and migration via upregulation of TEAD1/AREG in human endometrial cancer. Shimada H, et al. Sci Rep, 2017 Jan 10. PMID 28071680, Free PMC Article
  3. Tricellular tight junction protein LSR/angulin-1 contributes to the epithelial barrier and malignancy in human pancreatic cancer cell line. Kyuno T, et al. Histochem Cell Biol, 2020 Jan. PMID 31650247
  4. Localization of Tricellular Tight Junction Molecule LSR at Midbody and Centrosome During Cytokinesis in Human Epithelial Cells. Konno T, et al. J Histochem Cytochem, 2020 Jan. PMID 31662022, Free PMC Article
  5. Loss of LSR affects epithelial barrier integrity and tumor xenograft growth of CaCo-2 cells. Czulkies BA, et al. Oncotarget, 2017 Jun 6. PMID 27391068, Free PMC Article

See all (91) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Downregulation of angulin-1/LSR induces malignancy via upregulation of EGF-dependent claudin-2 and TGF-beta-dependent cell metabolism in human lung adenocarcinoma A549 cells.
    Title: Downregulation of angulin-1/LSR induces malignancy via upregulation of EGF-dependent claudin-2 and TGF-β-dependent cell metabolism in human lung adenocarcinoma A549 cells.
  2. LSR Promotes Cell Proliferation and Invasion in Lung Cancer.
    Title: LSR Promotes Cell Proliferation and Invasion in Lung Cancer.
  3. Translocation of LSR from tricellular corners causes macropinocytosis at cell-cell interface as a trigger for breaking out of contact inhibition.
    Title: Translocation of LSR from tricellular corners causes macropinocytosis at cell-cell interface as a trigger for breaking out of contact inhibition.
  4. Potentiation of cancerous progression by LISCH7 via direct stimulation of TGFB1 transcription in triple-negative breast cancer.
    Title: Potentiation of cancerous progression by LISCH7 via direct stimulation of TGFB1 transcription in triple-negative breast cancer.
  5. LSR promotes epithelial ovarian cancer cell survival under energy stress through the LKB1-AMPK pathway.
    Title: LSR promotes epithelial ovarian cancer cell survival under energy stress through the LKB1-AMPK pathway.
  6. Leptin Downregulates Angulin-1 in Active Crohn's Disease via STAT3.
    Title: Leptin Downregulates Angulin-1 in Active Crohn's Disease via STAT3.
  7. HMGB1-downregulated angulin-1/LSR induces epithelial barrier disruption via claudin-2 and cellular metabolism via AMPK in airway epithelial Calu-3 cells.
    Title: HMGB1-downregulated angulin-1/LSR induces epithelial barrier disruption via claudin-2 and cellular metabolism via AMPK in airway epithelial Calu-3 cells.
  8. ASPP2 suppression promotes malignancy via LSR and YAP in human endometrial cancer.
    Title: ASPP2 suppression promotes malignancy via LSR and YAP in human endometrial cancer.
  9. Localization of Tricellular Tight Junction Molecule LSR at Midbody and Centrosome During Cytokinesis in Human Epithelial Cells.
    Title: Localization of Tricellular Tight Junction Molecule LSR at Midbody and Centrosome During Cytokinesis in Human Epithelial Cells.
  10. In pancreatic cancer, LSR contributes to the epithelial barrier and malignancy via growth factors and may be a potential targeting molecule in the therapy.
    Title: Tricellular tight junction protein LSR/angulin-1 contributes to the epithelial barrier and malignancy in human pancreatic cancer cell line.
Submit: New GeneRIF Correction See all GeneRIFs (22)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC10659, MGC48312, MGC48503

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in epithelial structure maintenance ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in establishment of blood-brain barrier IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in establishment of blood-brain barrier ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in establishment of skin barrier ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in liver development ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within maintenance of blood-brain barrier NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in protein localization to tricellular tight junction ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in tricellular tight junction assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tricellular tight junction assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in bicellular tight junction IEA
Inferred from Electronic Annotation
more info
  
located_in cell junction IDA
Inferred from Direct Assay
more info
  
part_of chylomicron IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular exosome HDA PubMed 
part_of low-density lipoprotein particle IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in tight junction IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in tricellular tight junction IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in tricellular tight junction ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of very-low-density lipoprotein particle IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
lipolysis-stimulated lipoprotein receptor
Names
LISCH protein
angulin-1
immunoglobulin-like domain containing receptor 3
lipolysis-stimulated remnant
liver-specific bHLH-Zip transcription factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001260489.2 → NP_001247418.2  lipolysis-stimulated lipoprotein receptor isoform 4 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate splice site in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (4) is shorter than isoform 1.
    Source sequence(s)
    AC002128, AD000684
    Consensus CDS
    CCDS59376.2
    UniProtKB/TrEMBL
    A0A8Z5DL71, Q9BWS2
    Related
    ENSP00000472569.2, ENST00000602122.5
    Conserved Domains (1) summary
    PHA03307
    Location:243 → 538
    PHA03307; transcriptional regulator ICP4; Provisional

  2. NM_001260490.2 → NP_001247419.2  lipolysis-stimulated lipoprotein receptor isoform 5 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks two consecutive exons in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (5) is shorter than isoform 1.
    Source sequence(s)
    AC002128, AD000684
    Consensus CDS
    CCDS92587.1
    UniProtKB/TrEMBL
    Q9BWS2
    Related
    ENSP00000394479.1, ENST00000427250.5
    Conserved Domains (2) summary
    PHA03307
    Location:154 → 450
    PHA03307; transcriptional regulator ICP4; Provisional
    TIGR01622
    Location:371 → 485
    SF-CC1; splicing factor, CC1-like family

  3. NM_001385215.1 → NP_001372144.1  lipolysis-stimulated lipoprotein receptor isoform 6 precursor

    Status: VALIDATED

    Source sequence(s)
    AC002128, AD000684
    UniProtKB/TrEMBL
    Q9BWS2
    Conserved Domains (1) summary
    PHA03307
    Location:194 → 489
    PHA03307; transcriptional regulator ICP4; Provisional

  4. NM_015925.7 → NP_057009.4  lipolysis-stimulated lipoprotein receptor isoform 1 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AC002128, AD000684
    Consensus CDS
    CCDS12449.2
    UniProtKB/TrEMBL
    A0A8Z5ABK9, Q9BWS2
    Related
    ENSP00000346976.3, ENST00000354900.7
    Conserved Domains (1) summary
    PHA03307
    Location:243 → 539
    PHA03307; transcriptional regulator ICP4; Provisional

  5. NM_205834.4 → NP_991403.2  lipolysis-stimulated lipoprotein receptor isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) includes an alternate exon in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (2) is longer than isoform 1.
    Source sequence(s)
    AC002128, AD000684
    Consensus CDS
    CCDS12450.2
    UniProtKB/TrEMBL
    Q9BWS2, S4R3V8
    Related
    ENSP00000474797.2, ENST00000605618.6
    Conserved Domains (1) summary
    PHA03307
    Location:262 → 558
    PHA03307; transcriptional regulator ICP4; Provisional

  6. NM_205835.4 → NP_991404.2  lipolysis-stimulated lipoprotein receptor isoform 3 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an exon in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
    Source sequence(s)
    AC002128, AD000684
    Consensus CDS
    CCDS12451.2
    UniProtKB/TrEMBL
    A0A8Z5AA41, Q9BWS2
    Related
    ENSP00000354034.3, ENST00000360798.7
    Conserved Domains (1) summary
    PHA03307
    Location:194 → 490
    PHA03307; transcriptional regulator ICP4; Provisional

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    35249002..35267964
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005258980.3 → XP_005259037.2  lipolysis-stimulated lipoprotein receptor isoform X1

    Related
    ENSP00000262627.3, ENST00000347609.8

  2. XM_011527026.3 → XP_011525328.2  lipolysis-stimulated lipoprotein receptor isoform X2

  3. XM_047438920.1 → XP_047294876.1  lipolysis-stimulated lipoprotein receptor isoform X3

  4. XM_047438921.1 → XP_047294877.1  lipolysis-stimulated lipoprotein receptor isoform X4

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    37793654..37812636
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054321193.1 → XP_054177168.1  lipolysis-stimulated lipoprotein receptor isoform X1

  2. XM_054321194.1 → XP_054177169.1  lipolysis-stimulated lipoprotein receptor isoform X2

  3. XM_054321195.1 → XP_054177170.1  lipolysis-stimulated lipoprotein receptor isoform X3

  4. XM_054321196.1 → XP_054177171.1  lipolysis-stimulated lipoprotein receptor isoform X4

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q86X29.4 GenPept UniProtKB/Swiss-Prot:Q86X29

Gene LinkOut

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