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FAM13B family with sequence similarity 13 member B [ Homo sapiens (human) ]

Gene ID: 51306, updated on 27-Nov-2024

Summary

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Official Symbol
FAM13Bprovided by HGNC
Official Full Name
family with sequence similarity 13 member Bprovided by HGNC
Primary source
HGNC:HGNC:1335
See related
Ensembl:ENSG00000031003 MIM:609371; AllianceGenome:HGNC:1335
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
N61; KHCHP; C5orf5; FAM13B1; ARHGAP49
Summary
Predicted to enable GTPase activator activity. Predicted to be involved in regulation of small GTPase mediated signal transduction. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in testis (RPKM 17.1), endometrium (RPKM 11.7) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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See FAM13B in Genome Data Viewer
Location:
5q31.2
Exon count:
30
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (137937960..138052178, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (138464356..138578527, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (137273649..137374342, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107986368 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23188 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23189 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:137199613-137199779 Neighboring gene PKD2L2 divergent transcript Neighboring gene myotilin Neighboring gene polycystin 2 like 2, transient receptor potential cation channel Neighboring gene MPRA-validated peak5488 silencer Neighboring gene ReSE screen-validated silencer GRCh37_chr5:137338418-137338597 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23190 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:137366081-137366582 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23191 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:137367957-137368840 Neighboring gene uncharacterized LOC124901077 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23192 Neighboring gene FAM13B antisense RNA 1 Neighboring gene RNA, U6 small nuclear 1148, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:137425944-137426482 Neighboring gene Wnt family member 8A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. cDNA cloning and genomic structure of three genes localized to human chromosome band 5q31 encoding potential nuclear proteins. Lai F, et al. Genomics, 2000 Nov 15. PMID 11087669
  2. The eukaryotic elongation factor eEF1A1 interacts with SAMHD1. Morrissey C, et al. Biochem J, 2015 Feb 15. PMID 25423367
  3. Transcript map and comparative analysis of the 1.5-Mb commonly deleted segment of human 5q31 in malignant myeloid diseases with a del(5q). Lai F, et al. Genomics, 2001 Jan 15. PMID 11161817
  4. Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. Hu RM, et al. Proc Natl Acad Sci U S A, 2000 Aug 15. PMID 10931946, Free PMC Article
  5. Image-based genome-wide siRNA screen identifies selective autophagy factors. Orvedahl A, et al. Nature, 2011 Dec 1. PMID 22020285, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ26735, MGC57159, DKFZp667F249

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTPase activator activity TAS
Traceable Author Statement
more info
  
Process Evidence Code Pubs
involved_in regulation of small GTPase mediated signal transduction TAS
Traceable Author Statement
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
protein FAM13B
Names
GAP-like protein N61
family with sequence similarity 13, member B1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001101800.3 → NP_001095270.1  protein FAM13B isoform 2

    See identical proteins and their annotated locations for NP_001095270.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1, resulting in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AC113382, AF251038, AW592656, BC048965
    Consensus CDS
    CCDS47269.1
    UniProtKB/TrEMBL
    B2RAJ9
    Related
    ENSP00000388521.2, ENST00000420893.6
    Conserved Domains (2) summary
    cd04393
    Location:19 → 205
    RhoGAP_FAM13A1a; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of FAM13A1, isoform a-like proteins. The function of FAM13A1a is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound ...
    cl26235
    Location:829 → 868
    RecQL4_SLD2_NTD; N-terminal homeodomain-like domain of metazoan RecQ protein-like 4 (RecQL4), fungal DNA replication regulator SLD2 and similar proteins

  2. NM_001101801.3 → NP_001095271.1  protein FAM13B isoform 3

    See identical proteins and their annotated locations for NP_001095271.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has a distinct 5' UTR, lacks an in-frame portion of the 5' coding region, contains an alternate in-frame exon in the mid-coding region, and lacks an alternate in-frame exon in the 3' coding region, as compared to variant 1. This results in a shorter isoform (3) that has a truncated N-terminus, compared to isoform 1.
    Source sequence(s)
    AC113382, AF251038, AW592656, BC041335, BC048965, DA499233
    Consensus CDS
    CCDS47270.1
    UniProtKB/TrEMBL
    B2RAJ9
    Related
    ENSP00000394669.2, ENST00000425075.6
    Conserved Domains (2) summary
    cl02570
    Location:1 → 87
    RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
    cl26235
    Location:733 → 772
    RecQL4_SLD2_NTD; N-terminal homeodomain-like domain of metazoan RecQ protein-like 4 (RecQL4), fungal DNA replication regulator SLD2 and similar proteins

  3. NM_001385866.1 → NP_001372795.1  protein FAM13B isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC106753, AC113382
    UniProtKB/TrEMBL
    B2RAJ9
    Conserved Domains (2) summary
    cl02570
    Location:1 → 87
    RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
    cl26235
    Location:739 → 778
    RecQL4_SLD2_NTD; N-terminal homeodomain-like domain of metazoan RecQ protein-like 4 (RecQL4), fungal DNA replication regulator SLD2 and similar proteins

  4. NM_001385867.1 → NP_001372796.1  protein FAM13B isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC106753, AC113382
    Consensus CDS
    CCDS47269.1
    UniProtKB/TrEMBL
    B2RAJ9
    Conserved Domains (2) summary
    cd04393
    Location:19 → 205
    RhoGAP_FAM13A1a; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of FAM13A1, isoform a-like proteins. The function of FAM13A1a is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound ...
    cl26235
    Location:829 → 868
    RecQL4_SLD2_NTD; N-terminal homeodomain-like domain of metazoan RecQ protein-like 4 (RecQL4), fungal DNA replication regulator SLD2 and similar proteins

  5. NM_001385868.1 → NP_001372797.1  protein FAM13B isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC106753, AC113382
    UniProtKB/TrEMBL
    B2RAJ9
    Conserved Domains (2) summary
    cd04393
    Location:19 → 205
    RhoGAP_FAM13A1a; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of FAM13A1, isoform a-like proteins. The function of FAM13A1a is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound ...
    cl26235
    Location:851 → 890
    RecQL4_SLD2_NTD; N-terminal homeodomain-like domain of metazoan RecQ protein-like 4 (RecQL4), fungal DNA replication regulator SLD2 and similar proteins

  6. NM_001385869.1 → NP_001372798.1  protein FAM13B isoform 12

    Status: VALIDATED

    Source sequence(s)
    AC106753, AC113382
    Conserved Domains (1) summary
    cl26235
    Location:587 → 626
    RecQL4_SLD2_NTD; N-terminal homeodomain-like domain of metazoan RecQ protein-like 4 (RecQL4), fungal DNA replication regulator SLD2 and similar proteins

  7. NM_001385870.1 → NP_001372799.1  protein FAM13B isoform 10

    Status: VALIDATED

    Source sequence(s)
    AC106753, AC113382
    UniProtKB/TrEMBL
    B2RAJ9
    Conserved Domains (2) summary
    cd04393
    Location:19 → 205
    RhoGAP_FAM13A1a; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of FAM13A1, isoform a-like proteins. The function of FAM13A1a is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound ...
    cl26235
    Location:799 → 838
    RecQL4_SLD2_NTD; N-terminal homeodomain-like domain of metazoan RecQ protein-like 4 (RecQL4), fungal DNA replication regulator SLD2 and similar proteins

  8. NM_001385872.1 → NP_001372801.1  protein FAM13B isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC106753, AC113382
    UniProtKB/TrEMBL
    B2RAJ9
    Conserved Domains (2) summary
    cl02570
    Location:1 → 87
    RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
    cl26235
    Location:761 → 800
    RecQL4_SLD2_NTD; N-terminal homeodomain-like domain of metazoan RecQ protein-like 4 (RecQL4), fungal DNA replication regulator SLD2 and similar proteins

  9. NM_001385873.1 → NP_001372802.1  protein FAM13B isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC106753, AC113382
    Consensus CDS
    CCDS47270.1
    UniProtKB/TrEMBL
    B2RAJ9
    Conserved Domains (2) summary
    cl02570
    Location:1 → 87
    RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
    cl26235
    Location:733 → 772
    RecQL4_SLD2_NTD; N-terminal homeodomain-like domain of metazoan RecQ protein-like 4 (RecQL4), fungal DNA replication regulator SLD2 and similar proteins

  10. NM_001385874.1 → NP_001372803.1  protein FAM13B isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC106753, AC113382
    UniProtKB/TrEMBL
    B2RAJ9
    Conserved Domains (2) summary
    cd04393
    Location:19 → 205
    RhoGAP_FAM13A1a; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of FAM13A1, isoform a-like proteins. The function of FAM13A1a is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound ...
    cl26235
    Location:827 → 866
    RecQL4_SLD2_NTD; N-terminal homeodomain-like domain of metazoan RecQ protein-like 4 (RecQL4), fungal DNA replication regulator SLD2 and similar proteins

  11. NM_001385921.1 → NP_001372850.1  protein FAM13B isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC106753, AC113382
    Consensus CDS
    CCDS4195.1
    UniProtKB/Swiss-Prot
    D3DQB5, G3V0H9, Q3ZCR0, Q6PGQ2, Q9NYF5, Q9P0I7
    UniProtKB/TrEMBL
    A0A2X0SG06, B2RAJ9
    Conserved Domains (2) summary
    cd04393
    Location:19 → 205
    RhoGAP_FAM13A1a; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of FAM13A1, isoform a-like proteins. The function of FAM13A1a is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound ...
    cl26235
    Location:857 → 896
    RecQL4_SLD2_NTD; N-terminal homeodomain-like domain of metazoan RecQ protein-like 4 (RecQL4), fungal DNA replication regulator SLD2 and similar proteins

  12. NM_001385976.1 → NP_001372905.1  protein FAM13B isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC106753, AC113382
    UniProtKB/TrEMBL
    B2RAJ9
    Conserved Domains (2) summary
    cl02570
    Location:1 → 87
    RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
    cl26235
    Location:761 → 800
    RecQL4_SLD2_NTD; N-terminal homeodomain-like domain of metazoan RecQ protein-like 4 (RecQL4), fungal DNA replication regulator SLD2 and similar proteins

  13. NM_001385977.1 → NP_001372906.1  protein FAM13B isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC106753, AC113382
    UniProtKB/TrEMBL
    B2RAJ9
    Conserved Domains (2) summary
    cl02570
    Location:1 → 87
    RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
    cl26235
    Location:739 → 778
    RecQL4_SLD2_NTD; N-terminal homeodomain-like domain of metazoan RecQ protein-like 4 (RecQL4), fungal DNA replication regulator SLD2 and similar proteins

  14. NM_001385978.1 → NP_001372907.1  protein FAM13B isoform 13

    Status: VALIDATED

    Source sequence(s)
    AC106753, AC113382
    Conserved Domains (1) summary
    cl26235
    Location:639 → 678
    RecQL4_SLD2_NTD; N-terminal homeodomain-like domain of metazoan RecQ protein-like 4 (RecQL4), fungal DNA replication regulator SLD2 and similar proteins

  15. NM_001385979.1 → NP_001372908.1  protein FAM13B isoform 14

    Status: VALIDATED

    Source sequence(s)
    AC106753, AC113382
    UniProtKB/TrEMBL
    B2RAJ9
    Conserved Domains (2) summary
    cl02570
    Location:1 → 87
    RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
    cl26235
    Location:711 → 750
    RecQL4_SLD2_NTD; N-terminal homeodomain-like domain of metazoan RecQ protein-like 4 (RecQL4), fungal DNA replication regulator SLD2 and similar proteins

  16. NM_001385980.1 → NP_001372909.1  protein FAM13B isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC106753, AC113382
    UniProtKB/TrEMBL
    B2RAJ9
    Conserved Domains (2) summary
    cd04393
    Location:19 → 205
    RhoGAP_FAM13A1a; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of FAM13A1, isoform a-like proteins. The function of FAM13A1a is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound ...
    cl26235
    Location:851 → 890
    RecQL4_SLD2_NTD; N-terminal homeodomain-like domain of metazoan RecQ protein-like 4 (RecQL4), fungal DNA replication regulator SLD2 and similar proteins

  17. NM_001385991.1 → NP_001372920.1  protein FAM13B isoform 11

    Status: VALIDATED

    Source sequence(s)
    AC106753, AC113382
    UniProtKB/TrEMBL
    B2RAJ9
    Conserved Domains (2) summary
    cd04393
    Location:19 → 205
    RhoGAP_FAM13A1a; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of FAM13A1, isoform a-like proteins. The function of FAM13A1a is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound ...
    cl26235
    Location:797 → 836
    RecQL4_SLD2_NTD; N-terminal homeodomain-like domain of metazoan RecQ protein-like 4 (RecQL4), fungal DNA replication regulator SLD2 and similar proteins

  18. NM_001385992.1 → NP_001372921.1  protein FAM13B isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC106753, AC113382
    UniProtKB/TrEMBL
    B2RAJ9
    Conserved Domains (2) summary
    cd04393
    Location:19 → 205
    RhoGAP_FAM13A1a; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of FAM13A1, isoform a-like proteins. The function of FAM13A1a is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound ...
    cl26235
    Location:827 → 866
    RecQL4_SLD2_NTD; N-terminal homeodomain-like domain of metazoan RecQ protein-like 4 (RecQL4), fungal DNA replication regulator SLD2 and similar proteins

  19. NM_001385994.1 → NP_001372923.1  protein FAM13B isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC106753, AC113382
    Consensus CDS
    CCDS93788.1
    UniProtKB/TrEMBL
    A0A8I5KSB9, B2RAJ9
    Related
    ENSP00000509788.1, ENST00000689681.1
    Conserved Domains (2) summary
    cd04393
    Location:19 → 205
    RhoGAP_FAM13A1a; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of FAM13A1, isoform a-like proteins. The function of FAM13A1a is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound ...
    cl26235
    Location:879 → 918
    RecQL4_SLD2_NTD; N-terminal homeodomain-like domain of metazoan RecQ protein-like 4 (RecQL4), fungal DNA replication regulator SLD2 and similar proteins

  20. NM_001385995.1 → NP_001372924.1  protein FAM13B isoform 15

    Status: VALIDATED

    Source sequence(s)
    AC106753, AC113382
    UniProtKB/TrEMBL
    B2RAJ9
    Conserved Domains (2) summary
    cl02570
    Location:1 → 87
    RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
    cl26235
    Location:679 → 718
    RecQL4_SLD2_NTD; N-terminal homeodomain-like domain of metazoan RecQ protein-like 4 (RecQL4), fungal DNA replication regulator SLD2 and similar proteins

  21. NM_001385996.1 → NP_001372925.1  protein FAM13B isoform 16

    Status: VALIDATED

    Source sequence(s)
    AC106753, AC113382
    Conserved Domains (1) summary
    cl26235
    Location:667 → 706
    RecQL4_SLD2_NTD; N-terminal homeodomain-like domain of metazoan RecQ protein-like 4 (RecQL4), fungal DNA replication regulator SLD2 and similar proteins

  22. NM_001385997.1 → NP_001372926.1  protein FAM13B isoform 17

    Status: VALIDATED

    Source sequence(s)
    AC106753, AC113382
    UniProtKB/TrEMBL
    B2RAJ9
    Conserved Domains (2) summary
    cd04393
    Location:19 → 205
    RhoGAP_FAM13A1a; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of FAM13A1, isoform a-like proteins. The function of FAM13A1a is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound ...
    cl26235
    Location:777 → 816
    RecQL4_SLD2_NTD; N-terminal homeodomain-like domain of metazoan RecQ protein-like 4 (RecQL4), fungal DNA replication regulator SLD2 and similar proteins

  23. NM_001385998.1 → NP_001372927.1  protein FAM13B isoform 18

    Status: VALIDATED

    Source sequence(s)
    AC106753, AC113382
    Conserved Domains (1) summary
    cl26235
    Location:597 → 636
    RecQL4_SLD2_NTD; N-terminal homeodomain-like domain of metazoan RecQ protein-like 4 (RecQL4), fungal DNA replication regulator SLD2 and similar proteins

  24. NM_001385999.1 → NP_001372928.1  protein FAM13B isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC106753, AC113382
    UniProtKB/TrEMBL
    B2RAJ9
    Conserved Domains (2) summary
    cl02570
    Location:1 → 87
    RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
    cl26235
    Location:761 → 800
    RecQL4_SLD2_NTD; N-terminal homeodomain-like domain of metazoan RecQ protein-like 4 (RecQL4), fungal DNA replication regulator SLD2 and similar proteins

  25. NM_016603.4 → NP_057687.2  protein FAM13B isoform 1

    See identical proteins and their annotated locations for NP_057687.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC113382, AF251038, AW592656, BU183000, DA499233
    Consensus CDS
    CCDS4195.1
    UniProtKB/Swiss-Prot
    D3DQB5, G3V0H9, Q3ZCR0, Q6PGQ2, Q9NYF5, Q9P0I7
    UniProtKB/TrEMBL
    A0A2X0SG06, B2RAJ9
    Related
    ENSP00000033079.3, ENST00000033079.7
    Conserved Domains (2) summary
    cd04393
    Location:19 → 205
    RhoGAP_FAM13A1a; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of FAM13A1, isoform a-like proteins. The function of FAM13A1a is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound ...
    cl26235
    Location:857 → 896
    RecQL4_SLD2_NTD; N-terminal homeodomain-like domain of metazoan RecQ protein-like 4 (RecQL4), fungal DNA replication regulator SLD2 and similar proteins

RNA

  1. NR_169814.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC106753, AC113382

  2. NR_169815.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC106753, AC113382

  3. NR_169822.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC106753, AC113382

  4. NR_169823.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC106753, AC113382

  5. NR_169824.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC106753, AC113382

  6. NR_169825.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC106753, AC113382

  7. NR_169826.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC106753, AC113382

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    137937960..138052178 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006714648.2 → XP_006714711.1  protein FAM13B isoform X1

    See identical proteins and their annotated locations for XP_006714711.1

    UniProtKB/TrEMBL
    A0A8I5KSB9, B2RAJ9
    Conserved Domains (2) summary
    cd04393
    Location:19 → 205
    RhoGAP_FAM13A1a; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of FAM13A1, isoform a-like proteins. The function of FAM13A1a is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound ...
    cl26235
    Location:879 → 918
    RecQL4_SLD2_NTD; N-terminal homeodomain-like domain of metazoan RecQ protein-like 4 (RecQL4), fungal DNA replication regulator SLD2 and similar proteins

  2. XM_024446107.2 → XP_024301875.1  protein FAM13B isoform X1

    UniProtKB/TrEMBL
    A0A8I5KSB9, B2RAJ9
    Conserved Domains (2) summary
    cd04393
    Location:19 → 205
    RhoGAP_FAM13A1a; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of FAM13A1, isoform a-like proteins. The function of FAM13A1a is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound ...
    cl26235
    Location:879 → 918
    RecQL4_SLD2_NTD; N-terminal homeodomain-like domain of metazoan RecQ protein-like 4 (RecQL4), fungal DNA replication regulator SLD2 and similar proteins

  3. XM_017009550.2 → XP_016865039.1  protein FAM13B isoform X2

    UniProtKB/Swiss-Prot
    D3DQB5, G3V0H9, Q3ZCR0, Q6PGQ2, Q9NYF5, Q9P0I7
    UniProtKB/TrEMBL
    A0A2X0SG06, B2RAJ9
    Conserved Domains (2) summary
    cd04393
    Location:19 → 205
    RhoGAP_FAM13A1a; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of FAM13A1, isoform a-like proteins. The function of FAM13A1a is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound ...
    cl26235
    Location:857 → 896
    RecQL4_SLD2_NTD; N-terminal homeodomain-like domain of metazoan RecQ protein-like 4 (RecQL4), fungal DNA replication regulator SLD2 and similar proteins

  4. XM_011543450.2 → XP_011541752.1  protein FAM13B isoform X1

    See identical proteins and their annotated locations for XP_011541752.1

    UniProtKB/TrEMBL
    A0A8I5KSB9, B2RAJ9
    Conserved Domains (2) summary
    cd04393
    Location:19 → 205
    RhoGAP_FAM13A1a; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of FAM13A1, isoform a-like proteins. The function of FAM13A1a is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound ...
    cl26235
    Location:879 → 918
    RecQL4_SLD2_NTD; N-terminal homeodomain-like domain of metazoan RecQ protein-like 4 (RecQL4), fungal DNA replication regulator SLD2 and similar proteins

  5. XM_011543448.2 → XP_011541750.1  protein FAM13B isoform X1

    See identical proteins and their annotated locations for XP_011541750.1

    UniProtKB/TrEMBL
    A0A8I5KSB9, B2RAJ9
    Conserved Domains (2) summary
    cd04393
    Location:19 → 205
    RhoGAP_FAM13A1a; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of FAM13A1, isoform a-like proteins. The function of FAM13A1a is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound ...
    cl26235
    Location:879 → 918
    RecQL4_SLD2_NTD; N-terminal homeodomain-like domain of metazoan RecQ protein-like 4 (RecQL4), fungal DNA replication regulator SLD2 and similar proteins

  6. XM_047417286.1 → XP_047273242.1  protein FAM13B isoform X4

  7. XM_047417285.1 → XP_047273241.1  protein FAM13B isoform X3

  8. XM_011543449.2 → XP_011541751.1  protein FAM13B isoform X1

    See identical proteins and their annotated locations for XP_011541751.1

    UniProtKB/TrEMBL
    A0A8I5KSB9, B2RAJ9
    Conserved Domains (2) summary
    cd04393
    Location:19 → 205
    RhoGAP_FAM13A1a; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of FAM13A1, isoform a-like proteins. The function of FAM13A1a is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound ...
    cl26235
    Location:879 → 918
    RecQL4_SLD2_NTD; N-terminal homeodomain-like domain of metazoan RecQ protein-like 4 (RecQL4), fungal DNA replication regulator SLD2 and similar proteins

  9. XM_047417287.1 → XP_047273243.1  protein FAM13B isoform X4

  10. XM_047417284.1 → XP_047273240.1  protein FAM13B isoform X2

    UniProtKB/Swiss-Prot
    D3DQB5, G3V0H9, Q3ZCR0, Q6PGQ2, Q9NYF5, Q9P0I7
    UniProtKB/TrEMBL
    A0A2X0SG06

  11. XM_047417283.1 → XP_047273239.1  protein FAM13B isoform X1

    UniProtKB/TrEMBL
    A0A8I5KSB9

  12. XM_047417288.1 → XP_047273244.1  protein FAM13B isoform X4

  13. XM_017009549.2 → XP_016865038.1  protein FAM13B isoform X2

    UniProtKB/Swiss-Prot
    D3DQB5, G3V0H9, Q3ZCR0, Q6PGQ2, Q9NYF5, Q9P0I7
    UniProtKB/TrEMBL
    A0A2X0SG06, B2RAJ9
    Conserved Domains (2) summary
    cd04393
    Location:19 → 205
    RhoGAP_FAM13A1a; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of FAM13A1, isoform a-like proteins. The function of FAM13A1a is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound ...
    cl26235
    Location:857 → 896
    RecQL4_SLD2_NTD; N-terminal homeodomain-like domain of metazoan RecQ protein-like 4 (RecQL4), fungal DNA replication regulator SLD2 and similar proteins

  14. XM_047417282.1 → XP_047273238.1  protein FAM13B isoform X1

    UniProtKB/TrEMBL
    A0A8I5KSB9

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    138464356..138578527 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054352764.1 → XP_054208739.1  protein FAM13B isoform X1

    UniProtKB/TrEMBL
    A0A8I5KSB9

  2. XM_054352767.1 → XP_054208742.1  protein FAM13B isoform X1

    UniProtKB/TrEMBL
    A0A8I5KSB9

  3. XM_054352770.1 → XP_054208745.1  protein FAM13B isoform X2

    UniProtKB/Swiss-Prot
    D3DQB5, G3V0H9, Q3ZCR0, Q6PGQ2, Q9NYF5, Q9P0I7
    UniProtKB/TrEMBL
    A0A2X0SG06

  4. XM_054352766.1 → XP_054208741.1  protein FAM13B isoform X1

    UniProtKB/TrEMBL
    A0A8I5KSB9

  5. XM_054352765.1 → XP_054208740.1  protein FAM13B isoform X1

    UniProtKB/TrEMBL
    A0A8I5KSB9

  6. XM_054352772.1 → XP_054208747.1  protein FAM13B isoform X4

  7. XM_054352771.1 → XP_054208746.1  protein FAM13B isoform X3

  8. XM_054352761.1 → XP_054208736.1  protein FAM13B isoform X1

    UniProtKB/TrEMBL
    A0A8I5KSB9

  9. XM_054352769.1 → XP_054208744.1  protein FAM13B isoform X2

    UniProtKB/Swiss-Prot
    D3DQB5, G3V0H9, Q3ZCR0, Q6PGQ2, Q9NYF5, Q9P0I7
    UniProtKB/TrEMBL
    A0A2X0SG06

  10. XM_054352773.1 → XP_054208748.1  protein FAM13B isoform X4

  11. XM_054352763.1 → XP_054208738.1  protein FAM13B isoform X1

    UniProtKB/TrEMBL
    A0A8I5KSB9

  12. XM_054352774.1 → XP_054208749.1  protein FAM13B isoform X4

  13. XM_054352762.1 → XP_054208737.1  protein FAM13B isoform X1

    UniProtKB/TrEMBL
    A0A8I5KSB9

  14. XM_054352768.1 → XP_054208743.1  protein FAM13B isoform X2

    UniProtKB/Swiss-Prot
    D3DQB5, G3V0H9, Q3ZCR0, Q6PGQ2, Q9NYF5, Q9P0I7
    UniProtKB/TrEMBL
    A0A2X0SG06
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9NYF5.2 GenPept UniProtKB/Swiss-Prot:Q9NYF5

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