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CDK18 cyclin dependent kinase 18 [ Homo sapiens (human) ]

Gene ID: 5129, updated on 27-Nov-2024

Summary

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Official Symbol
CDK18provided by HGNC
Official Full Name
cyclin dependent kinase 18provided by HGNC
Primary source
HGNC:HGNC:8751
See related
Ensembl:ENSG00000117266 MIM:169190; AllianceGenome:HGNC:8751
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PCTK3; PCTAIRE; PCTAIRE3
Summary
Predicted to enable cyclin-dependent protein serine/threonine kinase activity. Involved in positive regulation of myelination. Located in mitochondrion. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in heart (RPKM 26.3), brain (RPKM 20.4) and 20 other tissues See more
Orthologs
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Genomic context

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See CDK18 in Genome Data Viewer
Location:
1q32.1
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (205504669..205532790)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (204769067..204797187)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (205473797..205501918)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene LEMD1 divergent transcript Neighboring gene tRNA-Lys (TTT) 8-1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1741 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:205450402-205451002 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:205459961-205460612 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:205475721-205476374 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:205479231-205479778 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:205480776-205481390 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:205484536-205485236 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:205486639-205487338 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:205490554-205491379 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1742 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:205505565-205506066 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1743 Neighboring gene Sharpr-MPRA regulatory region 5902 Neighboring gene MFSD4A antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:205538423-205538972 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:205538973-205539521 Neighboring gene RNA, U2 small nuclear 19, pseudogene Neighboring gene uncharacterized LOC124904491 Neighboring gene major facilitator superfamily domain containing 4A Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2381 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:205555399-205556189 Neighboring gene Sharpr-MPRA regulatory region 9898

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Human CDK18 promotes replication stress signaling and genome stability. Barone G, et al. Nucleic Acids Res, 2016 Oct 14. PMID 27382066, Free PMC Article
  2. Cyclin-dependent Kinase 18 Promotes Oligodendrocyte Precursor Cell Differentiation through Activating the Extracellular Signal-Regulated Kinase Signaling Pathway. Pan Y, et al. Neurosci Bull, 2019 Oct. PMID 31028571, Free PMC Article
  3. Cloning and expression analysis of two novel PCTAIRE 3 transcripts from human brain. Herskovits AZ, et al. Gene, 2004 Mar 17. PMID 15019984
  4. The regulation of tau phosphorylation by PCTAIRE 3: implications for the pathogenesis of Alzheimer's disease. Herskovits AZ, et al. Neurobiol Dis, 2006 Aug. PMID 16766195
  5. Potential role of PCTAIRE-2, PCTAIRE-3 and P-Histone H4 in amyloid precursor protein-dependent Alzheimer pathology. Chaput D, et al. Oncotarget, 2016 Feb 23. PMID 26885753, Free PMC Article

See all (54) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Genome-wide association study of early ischaemic stroke risk in Brazilian individuals with sickle cell disease implicates ADAMTS2 and CDK18 and uncovers novel loci.
    Title: Genome-wide association study of early ischaemic stroke risk in Brazilian individuals with sickle cell disease implicates ADAMTS2 and CDK18 and uncovers novel loci.
  2. Cyclin-Dependent Kinase 18 Controls Trafficking of Aquaporin-2 and Its Abundance through Ubiquitin Ligase STUB1, Which Functions as an AKAP.
    Title: Cyclin-Dependent Kinase 18 Controls Trafficking of Aquaporin-2 and Its Abundance through Ubiquitin Ligase STUB1, Which Functions as an AKAP.
  3. CDK18 knockdown or ATR inhibition in glioblastoma stem-like cells suppressed homologous recombination.
    Title: Myc targeted CDK18 promotes ATR and homologous recombination to mediate PARP inhibitor resistance in glioblastoma.
  4. these data reveal a rate-limiting role for CDK18 in replication stress signalling and establish it as a novel regulator of genome integrity.
    Title: Human CDK18 promotes replication stress signaling and genome stability.
  5. Increased levels of PCTAIRE3 is associated with Alzheimer's disease.
    Title: Potential role of PCTAIRE-2, PCTAIRE-3 and P-Histone H4 in amyloid precursor protein-dependent Alzheimer pathology.
  6. PCTAIRE 3 is aassociated kinase that modulates tau phosphorylation in Alzeheimer's disease.
    Title: The regulation of tau phosphorylation by PCTAIRE 3: implications for the pathogenesis of Alzheimer's disease.
  7. Expression of PCTAIRE 3a (474 amino acids) was evident throughout the brain and in the majority of tissues analyzed, while spliced isoform PCTAIRE 3b (504 amino acids) was limited to several subcortical nuclei of the basal gangli and the spinal cord.
    Title: Cloning and expression analysis of two novel PCTAIRE 3 transcripts from human brain.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study of plasma N6 polyunsaturated fatty acids within the cohorts for heart and aging research in genomic epidemiology consortium.
EBI GWAS Catalog
Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of cyclin-dependent kinase 18 (CDK18) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables cyclin-dependent protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in positive regulation of myelination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of cell cycle phase transition IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion HTP PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
cyclin-dependent kinase 18
Names
PCTAIRE protein kinase 3
PCTAIRE-motif protein kinase 3
cell division protein kinase 18
serine/threonine-protein kinase PCTAIRE-3
NP_002587.2
NP_997667.1
NP_997668.1
XP_011507904.2
XP_016856912.2
XP_047278158.1
XP_047278159.1
XP_047278163.1
XP_047278165.1
XP_047278166.1
XP_047278168.1
XP_054192892.1
XP_054192893.1
XP_054192894.1
XP_054192895.1
XP_054192896.1
XP_054192897.1
XP_054192898.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002596.4 → NP_002587.2  cyclin-dependent kinase 18 isoform b

    See identical proteins and their annotated locations for NP_002587.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding region compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Variants 2 and 3 both encode isoform b.
    Source sequence(s)
    AL357131, KF455139
    Consensus CDS
    CCDS44300.1
    UniProtKB/Swiss-Prot
    Q07002, Q5VXQ2, Q6V3A2, Q6V3A3, Q96F90
    UniProtKB/TrEMBL
    B4DK03
    Related
    ENSP00000353176.2, ENST00000360066.6
    Conserved Domains (1) summary
    cd07871
    Location:138 → 425
    STKc_PCTAIRE3; Catalytic domain of the Serine/Threonine Kinase, PCTAIRE-3 kinase

  2. NM_212502.3 → NP_997667.1  cyclin-dependent kinase 18 isoform b

    See identical proteins and their annotated locations for NP_997667.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in a coding exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Variants 2 and 3 both encode isoform b.
    Source sequence(s)
    AB209307, AY353237, BM695474
    Consensus CDS
    CCDS44300.1
    UniProtKB/Swiss-Prot
    Q07002, Q5VXQ2, Q6V3A2, Q6V3A3, Q96F90
    UniProtKB/TrEMBL
    B4DK03
    Related
    ENSP00000399082.2, ENST00000429964.7
    Conserved Domains (1) summary
    cd07871
    Location:138 → 425
    STKc_PCTAIRE3; Catalytic domain of the Serine/Threonine Kinase, PCTAIRE-3 kinase

  3. NM_212503.3 → NP_997668.1  cyclin-dependent kinase 18 isoform a

    See identical proteins and their annotated locations for NP_997668.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a).
    Source sequence(s)
    AL357131, KF455139
    Consensus CDS
    CCDS1454.1
    UniProtKB/TrEMBL
    B4DK03
    Related
    ENSP00000423665.1, ENST00000506784.5
    Conserved Domains (2) summary
    PLN00009
    Location:171 → 459
    PLN00009; cyclin-dependent kinase A; Provisional
    cd07871
    Location:168 → 455
    STKc_PCTAIRE3; Catalytic domain of the Serine/Threonine Kinase, PCTAIRE-3 kinase

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    205504669..205532790
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047422207.1 → XP_047278163.1  cyclin-dependent kinase 18 isoform X1

  2. XM_047422212.1 → XP_047278168.1  cyclin-dependent kinase 18 isoform X3

  3. XM_017001423.3 → XP_016856912.2  cyclin-dependent kinase 18 isoform X2

  4. XM_011509602.4 → XP_011507904.2  cyclin-dependent kinase 18 isoform X4

    UniProtKB/Swiss-Prot
    Q07002, Q5VXQ2, Q6V3A2, Q6V3A3, Q96F90

  5. XM_047422209.1 → XP_047278165.1  cyclin-dependent kinase 18 isoform X1

  6. XM_047422210.1 → XP_047278166.1  cyclin-dependent kinase 18 isoform X1

  7. XM_047422202.1 → XP_047278158.1  cyclin-dependent kinase 18 isoform X1

  8. XM_047422203.1 → XP_047278159.1  cyclin-dependent kinase 18 isoform X3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    204769067..204797187
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054336921.1 → XP_054192896.1  cyclin-dependent kinase 18 isoform X1

  2. XM_054336923.1 → XP_054192898.1  cyclin-dependent kinase 18 isoform X3

  3. XM_054336917.1 → XP_054192892.1  cyclin-dependent kinase 18 isoform X5

  4. XM_054336919.1 → XP_054192894.1  cyclin-dependent kinase 18 isoform X7

  5. XM_054336918.1 → XP_054192893.1  cyclin-dependent kinase 18 isoform X6

  6. XM_054336920.1 → XP_054192895.1  cyclin-dependent kinase 18 isoform X8

  7. XM_054336922.1 → XP_054192897.1  cyclin-dependent kinase 18 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q07002.4 GenPept UniProtKB/Swiss-Prot:Q07002

Gene LinkOut

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