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GCLC glutamate-cysteine ligase catalytic subunit [ Bos taurus (domestic cattle) ]

Gene ID: 512468, updated on 27-Dec-2024

Summary

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Official Symbol
GCLCprovided by VGNC
Official Full Name
glutamate-cysteine ligase catalytic subunitprovided by VGNC
Primary source
VGNC:VGNC:29289
See related
Ensembl:ENSBTAG00000015571
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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See GCLC in Genome Data Viewer
Location:
chromosome: 23
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 23 NC_037350.1 (6982221..7026848)

Chromosome 23 - NC_037350.1Genomic Context describing neighboring genes Neighboring gene leucine rich repeat containing 1 Neighboring gene kelch like family member 31 Neighboring gene major histocompatibility complex, class II, DY alpha Neighboring gene MHC class II antigen DS beta

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037350.1 Chromosome 23 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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Related articles in PubMed

  1. Glutathione content and expression of proteins involved with glutathione metabolism differs in longissimus dorsi, subcutaneous adipose, and liver tissues of finished vs. growing beef steers. Huang J, et al. J Anim Sci, 2018 Dec 3. PMID 30204884, Free PMC Article
  2. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
  3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables glutamate-cysteine ligase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in glutathione biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of glutamate-cysteine ligase complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
glutamate--cysteine ligase catalytic subunit
NP_001077143.1
XP_005223293.1
XP_005223294.1
XP_059736279.1
XP_059736280.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001083674.1 → NP_001077143.1  glutamate--cysteine ligase catalytic subunit

    See identical proteins and their annotated locations for NP_001077143.1

    Status: PROVISIONAL

    Source sequence(s)
    AY957499
    UniProtKB/TrEMBL
    A0A3Q1LU91, Q32S38
    Related
    ENSBTAP00000045984.1, ENSBTAT00000049040.3
    Conserved Domains (1) summary
    pfam03074
    Location:219 → 576
    GCS; Glutamate-cysteine ligase

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037350.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    6982221..7026848
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005223236.5 → XP_005223293.1  glutamate--cysteine ligase catalytic subunit isoform X1

    UniProtKB/TrEMBL
    A0A3Q1MN33, A0AAA9U023
    Related
    ENSBTAP00000070904.1, ENSBTAT00000081594.2
    Conserved Domains (2) summary
    pfam03074
    Location:236 → 609
    GCS; Glutamate-cysteine ligase
    cl28253
    Location:22 → 76
    RpsA; Ribosomal protein S1 [Translation, ribosomal structure and biogenesis]

  2. XM_005223237.5 → XP_005223294.1  glutamate--cysteine ligase catalytic subunit isoform X2

    UniProtKB/TrEMBL
    A0AAA9U023
    Related
    ENSBTAP00000102382.1, ENSBTAT00000118809.1
    Conserved Domains (2) summary
    pfam03074
    Location:236 → 608
    GCS; Glutamate-cysteine ligase
    cl28253
    Location:22 → 76
    RpsA; Ribosomal protein S1 [Translation, ribosomal structure and biogenesis]

  3. XM_059880297.1 → XP_059736280.1  glutamate--cysteine ligase catalytic subunit isoform X4

    UniProtKB/TrEMBL
    A0A3Q1LUC8, A0AAA9U023
    Related
    ENSBTAP00000060729.1, ENSBTAT00000074624.2

  4. XM_059880296.1 → XP_059736279.1  glutamate--cysteine ligase catalytic subunit isoform X3

    UniProtKB/TrEMBL
    A0AAA9U023
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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