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PLCE1 phospholipase C epsilon 1 [ Homo sapiens (human) ]

Gene ID: 51196, updated on 27-Nov-2024

Summary

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Official Symbol
PLCE1provided by HGNC
Official Full Name
phospholipase C epsilon 1provided by HGNC
Primary source
HGNC:HGNC:17175
See related
Ensembl:ENSG00000138193 MIM:608414; AllianceGenome:HGNC:17175
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PLCE; PPLC; NPHS3
Summary
This gene encodes a phospholipase enzyme that catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate to generate two second messengers: inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG). These second messengers subsequently regulate various processes affecting cell growth, differentiation, and gene expression. This enzyme is regulated by small monomeric GTPases of the Ras and Rho families and by heterotrimeric G proteins. In addition to its phospholipase C catalytic activity, this enzyme has an N-terminal domain with guanine nucleotide exchange (GEF) activity. Mutations in this gene cause early-onset nephrotic syndrome; characterized by proteinuria, edema, and diffuse mesangial sclerosis or focal and segmental glomerulosclerosis. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Sep 2009]
Expression
Broad expression in colon (RPKM 6.3), endometrium (RPKM 5.5) and 21 other tissues See more
Orthologs
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Genomic context

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See PLCE1 in Genome Data Viewer
Location:
10q23.33
Exon count:
39
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (93993931..94332823)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (94872907..95211918)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (95753688..96092580)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378438 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2632 Neighboring gene PIP5K1A and PSMD4 like (pseudogene) Neighboring gene RNY4 pseudogene 26 Neighboring gene uncharacterized LOC107984255 Neighboring gene PLCE1 antisense RNA 2 Neighboring gene histone deacetylase 1 pseudogene 1 Neighboring gene RNA, U6 small nuclear 657, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3787 Neighboring gene PLCE1 antisense RNA 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:96117703-96118368 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:96118369-96119034 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3788 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2633 Neighboring gene NOC3 like DNA replication regulator Neighboring gene MPRA-validated peak1050 silencer Neighboring gene MED14-independent group 3 enhancer GRCh37_chr10:96140095-96141294 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3789 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2634 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2635 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3790 Neighboring gene TBC1 domain family member 12 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:96304601-96305225 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:96305226-96305850 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:96305851-96306474 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:96335135-96335636 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:96335637-96336136 Neighboring gene MPRA-validated peak1052 silencer Neighboring gene helicase, lymphoid specific

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Comprehensive bioinformation analysis of the miRNA of PLCE1 knockdown in esophageal squamous cell carcinoma. Cui X, et al. Mol Cell Biochem, 2018 May. PMID 29238898
  2. Effects of PLCE1 gene silencing by RNA interference on cell cycling and apoptosis in esophageal carcinoma cells. Zhao L, et al. Asian Pac J Cancer Prev, 2014. PMID 25041015
  3. PLCE1 Promotes Esophageal Cancer Cell Progression by Maintaining the Transcriptional Activity of Snail. Zhai S, et al. Neoplasia, 2017 Mar. PMID 28147304, Free PMC Article
  4. Genetic polymorphism of the phospholipase C epsilon 1 gene and risk of gastric cancer. Liu X, et al. Chin Med J (Engl), 2014. PMID 24985593
  5. PLCE1 polymorphisms and expression combined with serum AFP level predicts survival of HBV-related hepatocellular carcinoma patients after hepatectomy. Liao X, et al. Oncotarget, 2017 Apr 25. PMID 28418898, Free PMC Article

See all (188) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PLCepsilon promotes the Warburg effect and tumorigenesis through AKT/GSK3beta/Cdc25a in bladder cancer.
    Title: PLCε promotes the Warburg effect and tumorigenesis through AKT/GSK3β/Cdc25a in bladder cancer.
  2. Phospholipase C epsilon-1 (PLCE1) mediates macrophage activation and protection against tuberculosis.
    Title: Phospholipase C epsilon-1 (PLCƐ1) mediates macrophage activation and protection against tuberculosis.
  3. Copy number variation analysis in 138 families with steroid-resistant nephrotic syndrome identifies causal homozygous deletions in PLCE1 and NPHS2 in two families.
    Title: Copy number variation analysis in 138 families with steroid-resistant nephrotic syndrome identifies causal homozygous deletions in PLCE1 and NPHS2 in two families.
  4. Association between the Missense Variant of PLCE1 and the Risk of Colorectal Cancer.
    Title: Association between the Missense Variant of PLCE1 and the Risk of Colorectal Cancer.
  5. Phospholipase Cepsilon insufficiency causes ascending aortic aneurysm and dissection.
    Title: Phospholipase Cε insufficiency causes ascending aortic aneurysm and dissection.
  6. [Association of GSTP1 and PLCE1 gene polymorphisms with primary esophageal cancer].
    Title: [Association of GSTP1 and PLCE1 gene polymorphisms with primary esophageal cancer].
  7. PLCE1 is a poor prognostic marker and may promote immune escape from osteosarcoma by the CD70-CD27 signaling pathway.
    Title: PLCE1 is a poor prognostic marker and may promote immune escape from osteosarcoma by the CD70-CD27 signaling pathway.
  8. PLCE1 as a diagnostic and prognostic biomarker by promoting the growth and progression of oral squamous cell carcinoma.
    Title: PLCE1 as a diagnostic and prognostic biomarker by promoting the growth and progression of oral squamous cell carcinoma.
  9. A broad clinical spectrum of PLCepsilon1-related kidney disease and intrafamilial variability.
    Title: A broad clinical spectrum of PLCε1-related kidney disease and intrafamilial variability.
  10. The Frequency of Genetic Mutations in Pediatric Patients Diagnosed with Nephrotic Syndrome: A Single-Center Retrospective Study in Saudi Arabia.
    Title: The Frequency of Genetic Mutations in Pediatric Patients Diagnosed with Nephrotic Syndrome: A Single-Center Retrospective Study in Saudi Arabia.
Submit: New GeneRIF Correction See all GeneRIFs (142)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Nephrotic syndrome, type 3
MedGen: C1853124 OMIM: 610725 GeneReviews: Genetic Steroid-Resistant Nephrotic Syndrome Overview
Compare labs

EBI GWAS Catalog

Description
A shared susceptibility locus in PLCE1 at 10q23 for gastric adenocarcinoma and esophageal squamous cell carcinoma.
EBI GWAS Catalog
Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk.
EBI GWAS Catalog
Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure.
EBI GWAS Catalog
Genome-wide association study identifies susceptibility loci for dengue shock syndrome at MICB and PLCE1.
EBI GWAS Catalog
Genome-wide association study identifies three new susceptibility loci for esophageal squamous-cell carcinoma in Chinese populations.
EBI GWAS Catalog
Genome-wide association study of personality traits in bipolar patients.
EBI GWAS Catalog
Genome-wide association study of smoking behaviours in patients with COPD.
EBI GWAS Catalog
GWAS for discovery and replication of genetic loci associated with sudden cardiac arrest in patients with coronary artery disease.
EBI GWAS Catalog
Joint analysis of three genome-wide association studies of esophageal squamous cell carcinoma in Chinese populations.
EBI GWAS Catalog
Meta-analysis of genome-wide association studies identifies novel loci that influence cupping and the glaucomatous process.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 envelope glycoproteins gp120 and gp160 directly and specifically impair the CD3/TcR-mediated activation of phospholipase C (PLC) via the CD4 molecule in uninfected T cells PubMed
Tat tat Phospholipase C/protein kinase C pathway-dependent phosphorylation of p44/42 and JNK MAP kinases is partially involved in IL-1beta induction by HIV-1 Tat PubMed
tat HIV-1 Tat induces release of calcium and TNF-alpha production, an effect mediated at least in part by activation of phospholipase C PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ23659, KIAA1516, MGC167842

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables enzyme binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables guanyl-nucleotide exchange factor activity TAS
Traceable Author Statement
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol phospholipase C activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol phospholipase C activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phospholipase C activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables small GTPase binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in Ras protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in Ras protein signal transduction IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in calcium-mediated signaling NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in diacylglycerol biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in diacylglycerol biosynthetic process TAS
Traceable Author Statement
more info
 PubMed 
involved_in epidermal growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in epidermal growth factor receptor signaling pathway NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in glomerulus development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular signal transduction IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in lipid catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphatidylinositol metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphatidylinositol-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of lamellipodium assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in release of sequestered calcium ion into cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in lamellipodium IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1
Names
PLC-epsilon-1
pancreas-enriched phospholipase C
phosphoinositide phospholipase C
phosphoinositide phospholipase C-epsilon-1
phosphoinositide-specific phospholipase C epsilon-1
NP_001159451.1
NP_001275918.1
NP_057425.3
XP_006717948.1
XP_006717951.1
XP_006717953.1
XP_011538152.1
XP_011538153.1
XP_011538154.1
XP_016871799.1
XP_016871800.1
XP_016871801.1
XP_047281240.1
XP_047281241.1
XP_047281242.1
XP_047281243.1
XP_047281244.1
XP_047281245.1
XP_047281246.1
XP_047281247.1
XP_047281248.1
XP_047281249.1
XP_047281250.1
XP_047281251.1
XP_047281252.1
XP_047281253.1
XP_047281254.1
XP_047281255.1
XP_047281256.1
XP_047281257.1
XP_047281258.1
XP_047281259.1
XP_054221979.1
XP_054221980.1
XP_054221981.1
XP_054221982.1
XP_054221983.1
XP_054221984.1
XP_054221985.1
XP_054221986.1
XP_054221987.1
XP_054221988.1
XP_054221989.1
XP_054221990.1
XP_054221991.1
XP_054221992.1
XP_054221993.1
XP_054221994.1
XP_054221995.1
XP_054221996.1
XP_054221997.1
XP_054221998.1
XP_054221999.1
XP_054222000.1
XP_054222001.1
XP_054222002.1
XP_054222003.1
XP_054222004.1
XP_054222005.1
XP_054222006.1

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_015799.2 RefSeqGene

    Range
    5002..343894
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001165979.2 → NP_001159451.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform 2

    See identical proteins and their annotated locations for NP_001159451.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks two exons and has an additional novel exon at its 5' end, compared to variant 1. These differences produce a unique 5' UTR and cause translation initiation at a novel start codon, compared to variant 1. The encoded protein (isoform 2; also known as PLCepsilon1b) has a shorter and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AF170071, AK289852, BC151854, BX491865
    Consensus CDS
    CCDS53555.1
    UniProtKB/TrEMBL
    A0A7I2PPM5
    Related
    ENSP00000501910.1, ENST00000675218.1
    Conserved Domains (6) summary
    cd00275
    Location:1564 → 1676
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd01780
    Location:1829 → 1928
    PLC_epsilon_RA; Ubiquitin-like domain of Phosphatidylinositide-specific phospholipase
    cd08596
    Location:1083 → 1525
    PI-PLCc_epsilon; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-epsilon
    PLN02952
    Location:1010 → 1675
    PLN02952; phosphoinositide phospholipase C
    pfam00617
    Location:231 → 405
    RasGEF; RasGEF domain
    pfam09279
    Location:1020 → 1071
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like

  2. NM_001288989.2 → NP_001275918.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform 3

    See identical proteins and their annotated locations for NP_001275918.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site in the coding region, compared to variant 1. This results in a shorter protein (isoform 3), compared to isoform 1.
    Source sequence(s)
    AL139124, AL355341, AL365510, BC144286, BC151854
    Consensus CDS
    CCDS91304.1
    UniProtKB/TrEMBL
    A0A8I5KVG7, B7ZM61
    Related
    ENSP00000508605.1, ENST00000692396.1
    Conserved Domains (6) summary
    cd00275
    Location:1856 → 1968
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08596
    Location:1375 → 1817
    PI-PLCc_epsilon; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-epsilon
    PLN02952
    Location:1302 → 1967
    PLN02952; phosphoinositide phospholipase C
    pfam00617
    Location:539 → 713
    RasGEF; RasGEF domain
    pfam09279
    Location:1312 → 1363
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
    cl00155
    Location:2121 → 2220
    UBQ; Ubiquitin-like proteins

  3. NM_016341.4 → NP_057425.3  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform 1

    See identical proteins and their annotated locations for NP_057425.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1; also known as PLCepsilon1a).
    Source sequence(s)
    AB040949, AF117948, AK074239, AL139124, AL355341, AL365510
    Consensus CDS
    CCDS41552.1
    UniProtKB/Swiss-Prot
    A6NGW0, A6NLA1, A7MBN7, A8K1D7, B9EIJ6, Q1X6H8, Q5VWL4, Q5VWL5, Q9H9X8, Q9HBX6, Q9HC53, Q9P212, Q9UHV3
    UniProtKB/TrEMBL
    A0A8I5KVG7
    Related
    ENSP00000360431.2, ENST00000371380.8
    Conserved Domains (6) summary
    cd08596
    Location:1391 → 1833
    PI-PLCc_epsilon; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-epsilon
    PLN02952
    Location:1318 → 1983
    PLN02952; phosphoinositide phospholipase C
    cd16203
    Location:1198 → 1378
    EFh_PI-PLCepsilon; EF-hand motif found in phosphoinositide phospholipase C epsilon 1 (PI-PLC-epsilon1)
    cd01780
    Location:2134 → 2236
    RA2_PLC-epsilon; Ras-associating (RA) domain 2 found in Phosphatidylinositide-specific phospholipase C (PLC)-epsilon
    cd17229
    Location:2007 → 2114
    RA1_PLC-epsilon; Ras-associating (RA) domain 1 found in Phosphatidylinositide-specific phospholipase C (PLC)-epsilon
    pfam00617
    Location:539 → 713
    RasGEF; RasGEF domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    93993931..94332823
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047425285.1 → XP_047281241.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1

  2. XM_047425289.1 → XP_047281245.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X3

    UniProtKB/Swiss-Prot
    A6NGW0, A6NLA1, A7MBN7, A8K1D7, B9EIJ6, Q1X6H8, Q5VWL4, Q5VWL5, Q9H9X8, Q9HBX6, Q9HC53, Q9P212, Q9UHV3

  3. XM_047425297.1 → XP_047281253.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X5

    UniProtKB/TrEMBL
    B7ZM61

  4. XM_047425287.1 → XP_047281243.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1

  5. XM_017016310.3 → XP_016871799.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1

    UniProtKB/TrEMBL
    A0A8I5KVG7
    Conserved Domains (6) summary
    cd00275
    Location:1886 → 1998
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08596
    Location:1391 → 1847
    PI-PLCc_epsilon; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-epsilon
    PLN02952
    Location:1318 → 1997
    PLN02952; phosphoinositide phospholipase C
    pfam00617
    Location:539 → 713
    RasGEF; RasGEF domain
    pfam09279
    Location:1328 → 1379
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
    cl00155
    Location:2151 → 2250
    UBQ; Ubiquitin-like proteins

  6. XM_047425290.1 → XP_047281246.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X3

    UniProtKB/Swiss-Prot
    A6NGW0, A6NLA1, A7MBN7, A8K1D7, B9EIJ6, Q1X6H8, Q5VWL4, Q5VWL5, Q9H9X8, Q9HBX6, Q9HC53, Q9P212, Q9UHV3

  7. XM_047425286.1 → XP_047281242.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1

  8. XM_006717885.5 → XP_006717948.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1

    See identical proteins and their annotated locations for XP_006717948.1

    UniProtKB/TrEMBL
    A0A8I5KVG7
    Conserved Domains (6) summary
    cd00275
    Location:1886 → 1998
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08596
    Location:1391 → 1847
    PI-PLCc_epsilon; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-epsilon
    PLN02952
    Location:1318 → 1997
    PLN02952; phosphoinositide phospholipase C
    pfam00617
    Location:539 → 713
    RasGEF; RasGEF domain
    pfam09279
    Location:1328 → 1379
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
    cl00155
    Location:2151 → 2250
    UBQ; Ubiquitin-like proteins

  9. XM_006717888.5 → XP_006717951.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X2

    UniProtKB/TrEMBL
    A0A8I5KVG7
    Conserved Domains (6) summary
    cd00275
    Location:1885 → 1997
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08596
    Location:1391 → 1846
    PI-PLCc_epsilon; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-epsilon
    PLN02952
    Location:1318 → 1996
    PLN02952; phosphoinositide phospholipase C
    pfam00617
    Location:539 → 713
    RasGEF; RasGEF domain
    pfam09279
    Location:1328 → 1379
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
    cl00155
    Location:2150 → 2249
    UBQ; Ubiquitin-like proteins

  10. XM_047425284.1 → XP_047281240.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1

  11. XM_047425291.1 → XP_047281247.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X3

    UniProtKB/Swiss-Prot
    A6NGW0, A6NLA1, A7MBN7, A8K1D7, B9EIJ6, Q1X6H8, Q5VWL4, Q5VWL5, Q9H9X8, Q9HBX6, Q9HC53, Q9P212, Q9UHV3

  12. XM_047425296.1 → XP_047281252.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X4

  13. XM_047425298.1 → XP_047281254.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X5

    UniProtKB/TrEMBL
    B7ZM61

  14. XM_047425294.1 → XP_047281250.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X3

    UniProtKB/Swiss-Prot
    A6NGW0, A6NLA1, A7MBN7, A8K1D7, B9EIJ6, Q1X6H8, Q5VWL4, Q5VWL5, Q9H9X8, Q9HBX6, Q9HC53, Q9P212, Q9UHV3

  15. XM_017016311.3 → XP_016871800.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1

    UniProtKB/TrEMBL
    A0A8I5KVG7
    Conserved Domains (6) summary
    cd00275
    Location:1886 → 1998
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08596
    Location:1391 → 1847
    PI-PLCc_epsilon; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-epsilon
    PLN02952
    Location:1318 → 1997
    PLN02952; phosphoinositide phospholipase C
    pfam00617
    Location:539 → 713
    RasGEF; RasGEF domain
    pfam09279
    Location:1328 → 1379
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
    cl00155
    Location:2151 → 2250
    UBQ; Ubiquitin-like proteins

  16. XM_047425288.1 → XP_047281244.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X2

  17. XM_047425292.1 → XP_047281248.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X3

    UniProtKB/Swiss-Prot
    A6NGW0, A6NLA1, A7MBN7, A8K1D7, B9EIJ6, Q1X6H8, Q5VWL4, Q5VWL5, Q9H9X8, Q9HBX6, Q9HC53, Q9P212, Q9UHV3

  18. XM_047425293.1 → XP_047281249.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X3

    UniProtKB/Swiss-Prot
    A6NGW0, A6NLA1, A7MBN7, A8K1D7, B9EIJ6, Q1X6H8, Q5VWL4, Q5VWL5, Q9H9X8, Q9HBX6, Q9HC53, Q9P212, Q9UHV3
    Related
    ENSP00000509490.1, ENST00000692286.1

  19. XM_011539851.4 → XP_011538153.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X12

    UniProtKB/TrEMBL
    A0A8I5KV08
    Conserved Domains (3) summary
    pfam00617
    Location:539 → 713
    RasGEF; RasGEF domain
    pfam09279
    Location:1328 → 1379
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
    cl14615
    Location:1391 → 1530
    PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily

  20. XM_011539852.4 → XP_011538154.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X13

    UniProtKB/TrEMBL
    A0A8I5KV08
    Related
    ENSP00000508416.1, ENST00000686954.1
    Conserved Domains (3) summary
    pfam00617
    Location:539 → 713
    RasGEF; RasGEF domain
    pfam09279
    Location:1328 → 1379
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
    cl14615
    Location:1391 → 1530
    PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily

  21. XM_047425295.1 → XP_047281251.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X4

  22. XM_047425300.1 → XP_047281256.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X5

    UniProtKB/TrEMBL
    B7ZM61

  23. XM_047425299.1 → XP_047281255.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X5

    UniProtKB/TrEMBL
    B7ZM61

  24. XM_006717890.4 → XP_006717953.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X6

    UniProtKB/TrEMBL
    A0A7I2PPM5
    Conserved Domains (6) summary
    cd00275
    Location:1578 → 1690
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd01780
    Location:1843 → 1942
    PLC_epsilon_RA; Ubiquitin-like domain of Phosphatidylinositide-specific phospholipase
    cd08596
    Location:1083 → 1539
    PI-PLCc_epsilon; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-epsilon
    PLN02952
    Location:1010 → 1689
    PLN02952; phosphoinositide phospholipase C
    pfam00617
    Location:231 → 405
    RasGEF; RasGEF domain
    pfam09279
    Location:1020 → 1071
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like

  25. XM_047425302.1 → XP_047281258.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X8

  26. XM_017016312.3 → XP_016871801.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X9

    UniProtKB/TrEMBL
    A0A7I2PPM5, A0A8I5KXT2
    Related
    ENSP00000509140.1, ENST00000688810.1

  27. XM_047425301.1 → XP_047281257.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X7

    Related
    ENSP00000360426.1, ENST00000371375.2

  28. XM_011539850.4 → XP_011538152.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X10

    UniProtKB/TrEMBL
    A0A7I2PPM5
    Conserved Domains (6) summary
    cd00275
    Location:1501 → 1613
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd01780
    Location:1766 → 1865
    PLC_epsilon_RA; Ubiquitin-like domain of Phosphatidylinositide-specific phospholipase
    cd08596
    Location:1006 → 1462
    PI-PLCc_epsilon; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-epsilon
    PLN02952
    Location:933 → 1612
    PLN02952; phosphoinositide phospholipase C
    pfam00617
    Location:154 → 328
    RasGEF; RasGEF domain
    pfam09279
    Location:943 → 994
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like

  29. XM_047425303.1 → XP_047281259.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X11

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    94872907..95211918
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054366006.1 → XP_054221981.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1

  2. XM_054366015.1 → XP_054221990.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X3

    UniProtKB/Swiss-Prot
    A6NGW0, A6NLA1, A7MBN7, A8K1D7, B9EIJ6, Q1X6H8, Q5VWL4, Q5VWL5, Q9H9X8, Q9HBX6, Q9HC53, Q9P212, Q9UHV3

  3. XM_054366023.1 → XP_054221998.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X5

    UniProtKB/TrEMBL
    B7ZM61

  4. XM_054366016.1 → XP_054221991.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X3

    UniProtKB/Swiss-Prot
    A6NGW0, A6NLA1, A7MBN7, A8K1D7, B9EIJ6, Q1X6H8, Q5VWL4, Q5VWL5, Q9H9X8, Q9HBX6, Q9HC53, Q9P212, Q9UHV3

  5. XM_054366012.1 → XP_054221987.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X3

    UniProtKB/Swiss-Prot
    A6NGW0, A6NLA1, A7MBN7, A8K1D7, B9EIJ6, Q1X6H8, Q5VWL4, Q5VWL5, Q9H9X8, Q9HBX6, Q9HC53, Q9P212, Q9UHV3

  6. XM_054366019.1 → XP_054221994.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X4

  7. XM_054366020.1 → XP_054221995.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X5

    UniProtKB/TrEMBL
    B7ZM61

  8. XM_054366008.1 → XP_054221983.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1

  9. XM_054366009.1 → XP_054221984.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1

  10. XM_054366013.1 → XP_054221988.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X3

    UniProtKB/Swiss-Prot
    A6NGW0, A6NLA1, A7MBN7, A8K1D7, B9EIJ6, Q1X6H8, Q5VWL4, Q5VWL5, Q9H9X8, Q9HBX6, Q9HC53, Q9P212, Q9UHV3

  11. XM_054366007.1 → XP_054221982.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1

  12. XM_054366005.1 → XP_054221980.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1

  13. XM_054366010.1 → XP_054221985.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X2

  14. XM_054366017.1 → XP_054221992.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X3

    UniProtKB/Swiss-Prot
    A6NGW0, A6NLA1, A7MBN7, A8K1D7, B9EIJ6, Q1X6H8, Q5VWL4, Q5VWL5, Q9H9X8, Q9HBX6, Q9HC53, Q9P212, Q9UHV3

  15. XM_054366004.1 → XP_054221979.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1

  16. XM_054366011.1 → XP_054221986.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X2

  17. XM_054366014.1 → XP_054221989.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X3

    UniProtKB/Swiss-Prot
    A6NGW0, A6NLA1, A7MBN7, A8K1D7, B9EIJ6, Q1X6H8, Q5VWL4, Q5VWL5, Q9H9X8, Q9HBX6, Q9HC53, Q9P212, Q9UHV3

  18. XM_054366030.1 → XP_054222005.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X12

  19. XM_054366031.1 → XP_054222006.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X13

  20. XM_054366018.1 → XP_054221993.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X4

  21. XM_054366022.1 → XP_054221997.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X5

    UniProtKB/TrEMBL
    B7ZM61

  22. XM_054366021.1 → XP_054221996.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X5

    UniProtKB/TrEMBL
    B7ZM61

  23. XM_054366028.1 → XP_054222003.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X10

  24. XM_054366029.1 → XP_054222004.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X11

  25. XM_054366024.1 → XP_054221999.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X6

  26. XM_054366026.1 → XP_054222001.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X8

  27. XM_054366027.1 → XP_054222002.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X9

    UniProtKB/TrEMBL
    A0A8I5KXT2

  28. XM_054366025.1 → XP_054222000.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X7

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9P212.3 GenPept UniProtKB/Swiss-Prot:Q9P212

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