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MEMO1 mediator of cell motility 1 [ Homo sapiens (human) ]

Gene ID: 51072, updated on 27-Nov-2024

Summary

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Official Symbol
MEMO1provided by HGNC
Official Full Name
mediator of cell motility 1provided by HGNC
Primary source
HGNC:HGNC:14014
See related
Ensembl:ENSG00000162959 MIM:611786; AllianceGenome:HGNC:14014
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MEMO; C2orf4; CGI-27; NS5ATP7
Summary
Involved in regulation of microtubule-based process. Located in cytosol and nucleus. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in testis (RPKM 22.5), bone marrow (RPKM 10.2) and 24 other tissues See more
Orthologs
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Genomic context

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See MEMO1 in Genome Data Viewer
Location:
2p22.3
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (31867823..32011008, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (31916231..32059416, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (32092892..32236077, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene keratin 18 pseudogene 52 Neighboring gene adenylate kinase 2 pseudogene 2 Neighboring gene NANOG hESC enhancer GRCh37_chr2:32111667-32112574 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11332 Neighboring gene MPRA-validated peak3645 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15554 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:32209277-32209778 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:32209779-32210278 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:32225693-32226193 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11334 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11335 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11333 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11336 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:32236012-32236171 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15555 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15556 Neighboring gene dpy-30 histone methyltransferase complex regulatory subunit Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15557 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:32288537-32289337 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11339 Neighboring gene spastin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. MEMO1 binds iron and modulates iron homeostasis in cancer cells. Dolgova N, et al. Elife, 2024 Apr 19. PMID 38640016, Free PMC Article
  2. Finding MEMO-Emerging Evidence for MEMO1's Function in Development and Disease. Schotanus MD, et al. Genes (Basel), 2020 Nov 6. PMID 33172038, Free PMC Article
  3. WD repeat protein 54-mediator of ErbB2-driven cell motility 1 axis promotes bladder cancer tumorigenesis and metastasis and impairs chemosensitivity. Wei X, et al. Cancer Lett, 2023 Mar 1. PMID 36627049
  4. Memo1 binds reduced copper ions, interacts with copper chaperone Atox1, and protects against copper-mediated redox activity in vitro. Zhang X, et al. Proc Natl Acad Sci U S A, 2022 Sep 13. PMID 36067318, Free PMC Article
  5. MEMO1, a new IRS1-interacting protein, induces epithelial-mesenchymal transition in mammary epithelial cells. Sorokin AV, et al. Oncogene, 2013 Jun 27. PMID 22824790

See all (51) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MEMO1 binds iron and modulates iron homeostasis in cancer cells.
    Title: MEMO1 binds iron and modulates iron homeostasis in cancer cells.
  2. WD repeat protein 54-mediator of ErbB2-driven cell motility 1 axis promotes bladder cancer tumorigenesis and metastasis and impairs chemosensitivity.
    Title: WD repeat protein 54-mediator of ErbB2-driven cell motility 1 axis promotes bladder cancer tumorigenesis and metastasis and impairs chemosensitivity.
  3. Memo1 binds reduced copper ions, interacts with copper chaperone Atox1, and protects against copper-mediated redox activity in vitro.
    Title: Memo1 binds reduced copper ions, interacts with copper chaperone Atox1, and protects against copper-mediated redox activity in vitro.
  4. miR-219a-1 inhibits colon cancer cells proliferation and invasion by targeting MEMO1.
    Title: miR-219a-1 inhibits colon cancer cells proliferation and invasion by targeting MEMO1.
  5. Finding MEMO-Emerging Evidence for MEMO1's Function in Development and Disease.
    Title: Finding MEMO-Emerging Evidence for MEMO1's Function in Development and Disease.
  6. Memo1 is a mediator of radial glial cell scaffold tiling, necessary to generate and organize neurons into functional ensembles in the developing cerebral cortex.
    Title: Memo1-Mediated Tiling of Radial Glial Cells Facilitates Cerebral Cortical Development.
  7. Study identify Memo as an important key mediator between the heregulin and estrogen signaling pathways, which affects both breast cancer cell migration and proliferation.
    Title: Memo interacts with c-Src to control Estrogen Receptor alpha sub-cellular localization.
  8. HRG/HER2/HER3 signaling promotes AhR-mediated Memo-1 expression and migration in colorectal cancer
    Title: HRG/HER2/HER3 signaling promotes AhR-mediated Memo-1 expression and migration in colorectal cancer.
  9. Observational study of gene-disease association. (HuGE Navigator)
    Title: Evidence for genes on chromosome 2 contributing to alcohol dependence with conduct disorder and suicide attempts.
  10. Biochemical assays revealed that Memo is a copper-dependent redox enzyme that promoted a more oxidized intracellular milieu and stimulated the production of reactive oxygen species (ROS) in cellular structures involved in migration.
    Title: Memo is a copper-dependent redox protein with an essential role in migration and metastasis.
Submit: New GeneRIF Correction See all GeneRIFs (17)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ25031, DKFZp434I0135

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of microtubule-based process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol HDA PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in nucleus HDA PubMed 

General protein information

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Preferred Names
protein MEMO1
Names
C21orf19-like protein
HCV NS5A-transactivated protein 7
hepatitis C virus NS5A-transactivated protein 7
mediator of ErbB2-driven cell motility 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001137602.4 → NP_001131074.1  protein MEMO1 isoform 2

    See identical proteins and their annotated locations for NP_001131074.1

    Status: VALIDATED

    Source sequence(s)
    AL121652, AL121655
    Consensus CDS
    CCDS46255.1
    UniProtKB/TrEMBL
    A8K3Y8
    Related
    ENSP00000400795.2, ENST00000426310.6
    Conserved Domains (1) summary
    cd07361
    Location:9 → 271
    MEMO_like; Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility

  2. NM_001301833.4 → NP_001288762.1  protein MEMO1 isoform 1

    See identical proteins and their annotated locations for NP_001288762.1

    Status: VALIDATED

    Source sequence(s)
    AL121652, AL121655
    Consensus CDS
    CCDS1776.1
    UniProtKB/Swiss-Prot
    B4DLS0, D6W575, Q5R2V8, Q5R2V9, Q6NSL5, Q9Y316
    UniProtKB/TrEMBL
    A8K3Y8
    Related
    ENSP00000385557.1, ENST00000404530.6
    Conserved Domains (1) summary
    cd07361
    Location:9 → 294
    MEMO_like; Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility

  3. NM_001301852.4 → NP_001288781.1  protein MEMO1 isoform 3

    See identical proteins and their annotated locations for NP_001288781.1

    Status: VALIDATED

    Source sequence(s)
    AL121652, AL121655
    UniProtKB/Swiss-Prot
    Q9Y316
    Conserved Domains (1) summary
    cl00599
    Location:114 → 198
    Extradiol_Dioxygenase_3B_like; Subunit B of Class III Extradiol ring-cleavage dioxygenases

  4. NM_001371912.2 → NP_001358841.1  protein MEMO1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL121652, AL121655
    UniProtKB/TrEMBL
    A8K3Y8
    Conserved Domains (1) summary
    cd07361
    Location:9 → 334
    MEMO_like; Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility

  5. NM_001371913.2 → NP_001358842.1  protein MEMO1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL121652, AL121655
    UniProtKB/TrEMBL
    A8K3Y8
    Conserved Domains (1) summary
    cd07361
    Location:18 → 303
    MEMO_like; Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility

  6. NM_001371914.2 → NP_001358843.1  protein MEMO1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL121652, AL121655
    Consensus CDS
    CCDS1776.1
    UniProtKB/Swiss-Prot
    B4DLS0, D6W575, Q5R2V8, Q5R2V9, Q6NSL5, Q9Y316
    UniProtKB/TrEMBL
    A8K3Y8
    Related
    ENSP00000368691.3, ENST00000379383.7
    Conserved Domains (1) summary
    cd07361
    Location:9 → 294
    MEMO_like; Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility

  7. NM_001371916.2 → NP_001358845.1  protein MEMO1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL121652, AL121655
    Consensus CDS
    CCDS46255.1
    UniProtKB/TrEMBL
    A8K3Y8
    Conserved Domains (1) summary
    cd07361
    Location:9 → 271
    MEMO_like; Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility

  8. NM_001371917.2 → NP_001358846.1  protein MEMO1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL121652, AL121655
    Conserved Domains (1) summary
    cl00599
    Location:114 → 198
    Extradiol_Dioxygenase_3B_like; Subunit B of Class III Extradiol ring-cleavage dioxygenases

  9. NM_001371918.2 → NP_001358847.1  protein MEMO1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL121652, AL121655
    Conserved Domains (1) summary
    cl00599
    Location:114 → 198
    Extradiol_Dioxygenase_3B_like; Subunit B of Class III Extradiol ring-cleavage dioxygenases

  10. NM_001371920.2 → NP_001358849.1  protein MEMO1 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AL121652, AL121655
    Conserved Domains (1) summary
    cd07361
    Location:9 → 196
    MEMO_like; Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility

  11. NM_001371921.2 → NP_001358850.1  protein MEMO1 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AL121652, AL121655
    Conserved Domains (1) summary
    cl00599
    Location:102 → 186
    Extradiol_Dioxygenase_3B_like; Subunit B of Class III Extradiol ring-cleavage dioxygenases

  12. NM_001385196.1 → NP_001372125.1  protein MEMO1 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AL121652, AL121655
    Conserved Domains (1) summary
    cd07361
    Location:103 → 388
    MEMO_like; Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility

  13. NM_015955.5 → NP_057039.1  protein MEMO1 isoform 1

    See identical proteins and their annotated locations for NP_057039.1

    Status: VALIDATED

    Source sequence(s)
    AL121652, AL121655
    Consensus CDS
    CCDS1776.1
    UniProtKB/Swiss-Prot
    B4DLS0, D6W575, Q5R2V8, Q5R2V9, Q6NSL5, Q9Y316
    UniProtKB/TrEMBL
    A8K3Y8
    Related
    ENSP00000295065.4, ENST00000295065.9
    Conserved Domains (1) summary
    cd07361
    Location:9 → 294
    MEMO_like; Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility

RNA

  1. NR_126032.3 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL121652, AL121655

  2. NR_126034.4 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL121652, AL121655
    Related
    ENST00000490459.5

  3. NR_163995.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL121652, AL121655

  4. NR_163996.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL121652, AL121655

  5. NR_163997.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL121652, AL121655

  6. NR_163998.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL121652, AL121655

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    31867823..32011008 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047444636.1 → XP_047300592.1  protein MEMO1 isoform X2

  2. XM_047444635.1 → XP_047300591.1  protein MEMO1 isoform X1

  3. XM_011532896.3 → XP_011531198.1  protein MEMO1 isoform X2

    See identical proteins and their annotated locations for XP_011531198.1

    Conserved Domains (1) summary
    cl00599
    Location:114 → 198
    Extradiol_Dioxygenase_3B_like; Subunit B of Class III Extradiol ring-cleavage dioxygenases

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    31916231..32059416 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054342390.1 → XP_054198365.1  protein MEMO1 isoform X2

  2. XM_054342389.1 → XP_054198364.1  protein MEMO1 isoform X1

  3. XM_054342391.1 → XP_054198366.1  protein MEMO1 isoform X2

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001371915.1: Suppressed sequence

    Description
    NM_001371915.1: This RefSeq record was removed by NCBI staff. Contact [email protected] for further information.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Y316.1 GenPept UniProtKB/Swiss-Prot:Q9Y316

Gene LinkOut

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