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BOLA-NC1 non-classical MHC class I antigen [ Bos taurus (domestic cattle) ]

Gene ID: 510417, updated on 31-Dec-2024

Summary

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Gene symbol
BOLA-NC1
Gene description
non-classical MHC class I antigen
See related
Ensembl:ENSBTAG00000002069
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as
BoLA; BoLA-NC
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Genomic context

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See BOLA-NC1 in Genome Data Viewer
Location:
chromosome: 23
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 23 NC_037350.1 (28547672..28552334, complement)

Chromosome 23 - NC_037350.1Genomic Context describing neighboring genes Neighboring gene mitochondrial import receptor subunit TOM20 homolog Neighboring gene major histocompatibility complex, class I Neighboring gene BOLA class I histocompatibility antigen, alpha chain BL3-7-like Neighboring gene uncharacterized LOC132343678 Neighboring gene uncharacterized LOC104975666 Neighboring gene uncharacterized LOC132343677 Neighboring gene MHC Class I JSP.1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037350.1 Chromosome 23 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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Related articles in PubMed

  1. A BAC contig of approximately 400 kb contains the classical class I major histocompatibility complex (MHC) genes of cattle. Di Palma F, et al. Eur J Immunogenet, 2002 Feb. PMID 11841492
  2. Non-classical major histocompatibility complex class makes a crucial contribution to reproduction in the dairy cow. Shu L, et al. J Reprod Dev, 2012. PMID 22785322
  3. cDNA sequence of cattle MHC class I genes transcribed in serologically defined haplotypes A18 and A31. Ellis SA, et al. Immunogenetics, 1996. PMID 8550100
  4. A novel RNAseq-assisted method for MHC class I genotyping in a non-model species applied to a lethal vaccination-induced alloimmune disease. Demasius W, et al. BMC Genomics, 2016 May 17. PMID 27188848, Free PMC Article
  5. Evolution of major histocompatibility complex class I genes in Cetartiodactyls. Holmes EC, et al. Immunogenetics, 2003 Jul. PMID 12756505

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC134252

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables peptide antigen binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables signaling receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in antigen processing and presentation of endogenous peptide antigen via MHC class Ib IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in immune response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of T cell mediated cytotoxicity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in external side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
non-classical MHC class I antigen
Names
MHC class I antigen
MHC class I heavy chain
non-MHC class I antigen
non-classical MHC class I antigen NC1*00601

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001435203.1 → NP_001422132.1  non-classical MHC class I antigen isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    NKLS02000023

  2. NM_001435204.1 → NP_001422133.1  non-classical MHC class I antigen isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    NKLS02000023

RNA

  1. NR_198909.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    NKLS02000023

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037350.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    28547672..28552334 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_059880288.1 → XP_059736271.1  non-classical MHC class I antigen isoform X3

    UniProtKB/TrEMBL
    F1N4Y5

  2. XM_059880290.1 → XP_059736273.1  non-classical MHC class I antigen isoform X5

    UniProtKB/TrEMBL
    A0A0K1L4Z1, H6V5G4

  3. XM_059880289.1 → XP_059736272.1  non-classical MHC class I antigen isoform X4

    UniProtKB/TrEMBL
    H6V5G4
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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