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GSR glutathione-disulfide reductase [ Bos taurus (domestic cattle) ]

Gene ID: 506406, updated on 4-Oct-2024

Summary

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Official Symbol
GSRprovided by VGNC
Official Full Name
glutathione-disulfide reductaseprovided by VGNC
Primary source
VGNC:VGNC:29682
See related
BGD:BT27146; Ensembl:ENSBTAG00000007115
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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See GSR in Genome Data Viewer
Location:
chromosome: 27
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 27 NC_037354.1 (26801918..26846927, complement)

Chromosome 27 - NC_037354.1Genomic Context describing neighboring genes Neighboring gene RNA binding protein, mRNA processing factor Neighboring gene microRNA mir-2399 Neighboring gene general transcription factor IIE subunit 2 Neighboring gene small integral membrane protein 18 Neighboring gene large ribosomal subunit protein uL24-like Neighboring gene UBX domain protein 8

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037354.1 Chromosome 27 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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Related articles in PubMed

  1. Total glutathione and glutathione reductase in bovine erythrocytes and liver biopsy. Abd Ellah MR, et al. J Vet Med Sci, 2008 Aug. PMID 18772567
  2. Synteny mapping of human chromosome 8 loci in cattle. Threadgill DW, et al. Anim Genet, 1991. PMID 1909844
  3. Glutathione content and expression of proteins involved with glutathione metabolism differs in longissimus dorsi, subcutaneous adipose, and liver tissues of finished vs. growing beef steers. Huang J, et al. J Anim Sci, 2018 Dec 3. PMID 30204884, Free PMC Article
  4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables NADP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables flavin adenine dinucleotide binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables glutathione-disulfide reductase (NADPH) activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell redox homeostasis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cellular response to oxidative stress IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in glutathione metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
glutathione reductase, mitochondrial
Names
glutathione reductase
NP_001107662.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001114190.2 → NP_001107662.1  glutathione reductase, mitochondrial

    Status: VALIDATED

    Source sequence(s)
    DV820297, DV884056, EE253355, EH148178, EV753873, NKLS02000027
    UniProtKB/TrEMBL
    A0AAA9TCS2, E1BKZ1
    Related
    ENSBTAP00000009363.6, ENSBTAT00000009363.7
    Conserved Domains (4) summary
    TIGR01421
    Location:61 → 519
    gluta_reduc_1; glutathione-disulfide reductase, animal/bacterial
    pfam00070
    Location:230 → 306
    Pyr_redox; Pyridine nucleotide-disulphide oxidoreductase
    pfam02852
    Location:409 → 517
    Pyr_redox_dim; Pyridine nucleotide-disulphide oxidoreductase, dimerization domain
    cl21454
    Location:181 → 243
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037354.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    26801918..26846927 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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