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Chrna10 cholinergic receptor, nicotinic, alpha polypeptide 10 [ Mus musculus (house mouse) ]

Gene ID: 504186, updated on 27-Nov-2024

Summary

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Official Symbol
Chrna10provided by MGI
Official Full Name
cholinergic receptor, nicotinic, alpha polypeptide 10provided by MGI
Primary source
MGI:MGI:3609260
See related
Ensembl:ENSMUSG00000066279 AllianceGenome:MGI:3609260
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables acetylcholine-gated monoatomic cation-selective channel activity. Acts upstream of or within cholinergic synaptic transmission; detection of mechanical stimulus involved in sensory perception of sound; and inner ear morphogenesis. Predicted to be located in axon and perikaryon. Predicted to be part of transmembrane transporter complex. Predicted to be active in cholinergic synapse; neuron projection; and postsynaptic specialization membrane. Orthologous to human CHRNA10 (cholinergic receptor nicotinic alpha 10 subunit). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in frontal lobe adult (RPKM 2.5), heart adult (RPKM 1.2) and 8 other tissues See more
Orthologs
human all
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Genomic context

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See Chrna10 in Genome Data Viewer
Location:
7 E2; 7 54.71 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (101760469..101766564, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (102111260..102116971, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene Xndc1-transient receptor potential cation channel, subfamily C, member 2 readthrough Neighboring gene Xrcc1 N-terminal domain containing 1 Neighboring gene transient receptor potential cation channel, subfamily C, member 2 Neighboring gene ADP-ribosyltransferase 5 Neighboring gene ADP-ribosyltransferase 1 Neighboring gene STARR-seq mESC enhancer starr_19704 Neighboring gene nucleoporin 98 Neighboring gene STARR-seq mESC enhancer starr_19705 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:109358847-109359078 Neighboring gene post-GPI attachment to proteins 2 Neighboring gene ras homolog family member G

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. SK2 channels are required for function and long-term survival of efferent synapses on mammalian outer hair cells. Murthy V, et al. Mol Cell Neurosci, 2009 Jan. PMID 18848895, Free PMC Article
  2. A point mutation in the hair cell nicotinic cholinergic receptor prolongs cochlear inhibition and enhances noise protection. Taranda J, et al. PLoS Biol, 2009 Jan 20. PMID 19166271, Free PMC Article
  3. Characterization of HA-tagged α9 and α10 nAChRs in the mouse cochlea. Vyas P, et al. Sci Rep, 2020 Dec 11. PMID 33311584, Free PMC Article
  4. Constitutive expression of the alpha10 nicotinic acetylcholine receptor subunit fails to maintain cholinergic responses in inner hair cells after the onset of hearing. Taranda J, et al. J Assoc Res Otolaryngol, 2009 Sep. PMID 19452222, Free PMC Article
  5. Attenuation in Nicotinic Acetylcholine Receptor α9 and α10 Subunit Double Knock-Out Mice of Experimental Autoimmune Encephalomyelitis. Liu Q, et al. Biomolecules, 2019 Dec 4. PMID 31817275, Free PMC Article

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Alpha9alpha10 knockout mice show altered physiological and behavioral responses to signals in masking noise.
    Title: Alpha9alpha10 knockout mice show altered physiological and behavioral responses to signals in masking noise.
  2. Efferent feedback controls bilateral auditory spontaneous activity.
    Title: Efferent feedback controls bilateral auditory spontaneous activity.
  3. Characterization of HA-tagged alpha9 and alpha10 nAChRs in the mouse cochlea.
    Title: Characterization of HA-tagged α9 and α10 nAChRs in the mouse cochlea.
  4. Attenuation in Nicotinic Acetylcholine Receptor alpha9 and alpha10 Subunit Double Knock-Out Mice of Experimental Autoimmune Encephalomyelitis.
    Title: Attenuation in Nicotinic Acetylcholine Receptor α9 and α10 Subunit Double Knock-Out Mice of Experimental Autoimmune Encephalomyelitis.
  5. we developed RgIA4, a peptide that exhibits high potency for both human and rodent a9a10 nAChRs, and was at least 1,000-fold more selective for a9a10 nAChRs vs. all other molecular targets tested, including opioid and GABAB receptors
    Title: Inhibition of α9α10 nicotinic acetylcholine receptors prevents chemotherapy-induced neuropathic pain.
  6. Multiple features of the efferent postsynaptic complex to inner hair cells, in addition to the alpha9alpha10 nicotinic cholinergic receptors, are down-regulated in synchrony after the onset of hearing, leading to lack of responses to acetylcholine.
    Title: Constitutive expression of the alpha10 nicotinic acetylcholine receptor subunit fails to maintain cholinergic responses in inner hair cells after the onset of hearing.
  7. Co-expression of the alpha10 subunit converts the normally weak acetylcholine-mediated activity of alpha9 to a more robustly active channel with identical physiological characteristics of the native mammalian outer hair cell cholinergic receptor.
    Title: alpha10: a determinant of nicotinic cholinergic receptor function in mammalian vestibular and cochlear mechanosensory hair cells.
  8. Results demonstrate that alpha9(-/-) and alpha10(-/-) mice have overlapping but nonidentical phenotypes.
    Title: The alpha10 nicotinic acetylcholine receptor subunit is required for normal synaptic function and integrity of the olivocochlear system.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables acetylcholine-gated monoatomic cation-selective channel activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables excitatory extracellular ligand-gated monoatomic ion channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables serotonin-gated monoatomic cation channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within detection of mechanical stimulus involved in sensory perception of sound IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within inner ear morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in monoatomic ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of cytosolic calcium ion concentration ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within synaptic transmission, cholinergic IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in axon ISO
Inferred from Sequence Orthology
more info
  
is_active_in cholinergic synapse ISO
Inferred from Sequence Orthology
more info
  
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in perikaryon ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in postsynaptic specialization membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of transmembrane transporter complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
neuronal acetylcholine receptor subunit alpha-10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081424.1 → NP_001074893.1  neuronal acetylcholine receptor subunit alpha-10 precursor

    See identical proteins and their annotated locations for NP_001074893.1

    Status: PROVISIONAL

    Source sequence(s)
    AC118592, AC132297
    Consensus CDS
    CCDS40047.1
    UniProtKB/TrEMBL
    B2RX82
    Related
    ENSMUSP00000081891.2, ENSMUST00000084830.2
    Conserved Domains (3) summary
    cd19051
    Location:239 → 324
    LGIC_TM_cation; transmembrane domain of Cys-loop neurotransmitter-gated ion channels, includes 5HT3, nAChR, and ZAC
    cl28912
    Location:30 → 236
    LGIC_ECD; extracellular domain (ECD) of Cys-loop neurotransmitter-gated ion channels (also known as ligand-gated ion channel (LGIC))
    pfam02932
    Location:243 → 437
    Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    101760469..101766564 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006508009.4 → XP_006508072.1  neuronal acetylcholine receptor subunit alpha-10 isoform X1

    See identical proteins and their annotated locations for XP_006508072.1

    UniProtKB/TrEMBL
    B2RX82
    Conserved Domains (3) summary
    cd19051
    Location:239 → 324
    LGIC_TM_cation; transmembrane domain of Cys-loop neurotransmitter-gated ion channels, includes 5HT3, nAChR, and ZAC
    cl28912
    Location:30 → 236
    LGIC_ECD; extracellular domain (ECD) of Cys-loop neurotransmitter-gated ion channels (also known as ligand-gated ion channel (LGIC))
    pfam02932
    Location:243 → 437
    Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

  2. XM_006508008.5 → XP_006508071.1  neuronal acetylcholine receptor subunit alpha-10 isoform X1

    See identical proteins and their annotated locations for XP_006508071.1

    UniProtKB/TrEMBL
    B2RX82
    Conserved Domains (3) summary
    cd19051
    Location:239 → 324
    LGIC_TM_cation; transmembrane domain of Cys-loop neurotransmitter-gated ion channels, includes 5HT3, nAChR, and ZAC
    cl28912
    Location:30 → 236
    LGIC_ECD; extracellular domain (ECD) of Cys-loop neurotransmitter-gated ion channels (also known as ligand-gated ion channel (LGIC))
    pfam02932
    Location:243 → 437
    Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region
Nucleotide Protein Strain
Heading Accession and Version

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