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ly75 lymphocyte antigen 75 [ Danio rerio (zebrafish) ]

Gene ID: 504036, updated on 4-Jan-2025

Summary

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Official Symbol
ly75provided by ZNC
Official Full Name
lymphocyte antigen 75provided by ZNC
Primary source
ZFIN:ZDB-GENE-050309-166
See related
Ensembl:ENSDARG00000053113 AllianceGenome:ZFIN:ZDB-GENE-050309-166
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
im:7150926; si:dkey-78p20.2
Summary
Predicted to enable signaling receptor activity. Predicted to act upstream of or within endocytosis. Predicted to be located in membrane. Predicted to be active in external side of plasma membrane. Is expressed in heart and macrophage. Orthologous to several human genes including LY75 (lymphocyte antigen 75). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
human mouse all
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Genomic context

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See ly75 in Genome Data Viewer
Location:
chromosome: 11
Exon count:
35
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 11 NC_007122.7 (11120634..11193055)
105 previous assembly GRCz10 (GCF_000002035.5) 11 NC_007122.6 (11136989..11209434)

Chromosome 11 - NC_007122.7Genomic Context describing neighboring genes Neighboring gene integrin, beta 6 Neighboring gene phospholipase A2 receptor 1 Neighboring gene myomesin 2a Neighboring gene lengsin, lens protein with glutamine synthetase domain

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Alterations in cardiac DNA methylation in human dilated cardiomyopathy. Haas J, et al. EMBO Mol Med, 2013 Mar. PMID 23341106, Free PMC Article
  2. Identification and migration of primordial germ cells in Atlantic salmon, Salmo salar: characterization of vasa, dead end, and lymphocyte antigen 75 genes. Nagasawa K, et al. Mol Reprod Dev, 2013 Feb. PMID 23239145, Free PMC Article
  3. Molecular insights of organochlorine biocide-induced toxicity in zebrafish: Whole-adult-organism toxicogenomics, targeted gene expression and histological analyses. Lui EY, et al. J Genet Genomics, 2016 Aug 20. PMID 27503704
  4. Induced autoimmunity against gonadal proteins affects gonadal development in juvenile zebrafish. Presslauer C, et al. PLoS One, 2014. PMID 25436775, Free PMC Article
  5. Molecular dissection of the migrating posterior lateral line primordium during early development in zebrafish. Gallardo VE, et al. BMC Dev Biol, 2010 Dec 13. PMID 21144052, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within endocytosis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
lymphocyte antigen 75

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007122.7 Reference GRCz11 Primary Assembly

    Range
    11120634..11193055
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009305864.4 → XP_009304139.1  lymphocyte antigen 75

    UniProtKB/TrEMBL
    A0A8M3BDJ8, F1QS24
    Related
    ENSDARP00000011500.7, ENSDART00000026135.10
    Conserved Domains (4) summary
    smart00059
    Location:160 → 208
    FN2; Fibronectin type 2 domain
    cd00037
    Location:227 → 340
    CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
    smart00034
    Location:958 → 1093
    CLECT; C-type lectin (CTL) or carbohydrate-recognition domain (CRD)
    smart00458
    Location:37 → 132
    RICIN; Ricin-type beta-trefoil
Nucleotide Protein Strain
Heading Accession and Version

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