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eps8l1a EPS8 signaling adaptor L1a [ Danio rerio (zebrafish) ]

Gene ID: 503735, updated on 9-Dec-2024

Summary

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Official Symbol
eps8l1aprovided by ZNC
Official Full Name
EPS8 signaling adaptor L1aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-050306-14
See related
Ensembl:ENSDARG00000057984 AllianceGenome:ZFIN:ZDB-GENE-050306-14
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
eps8l1; zgc:113583
Summary
Predicted to enable actin binding activity. Predicted to be involved in Rho protein signal transduction; positive regulation of ruffle assembly; and regulation of Rho protein signal transduction. Predicted to be active in ruffle membrane. Orthologous to human EPS8L1 (EPS8 signaling adaptor L1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See eps8l1a in Genome Data Viewer
Location:
chromosome: 3
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (16513226..16537441, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (16363395..16388807, complement)

Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene potassium inwardly rectifying channel subfamily J member 12b Neighboring gene myosin-9 Neighboring gene solute carrier family 6 member 16a Neighboring gene uncharacterized LOC137490516

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables actin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in Rho protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of ruffle assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of Rho protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in ruffle membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
epidermal growth factor receptor kinase substrate 8-like protein 1a
Names
eps8 like 1a
eps8-like1
eps8-like1a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013313.1 → NP_001013331.1  epidermal growth factor receptor kinase substrate 8-like protein 1a

    See identical proteins and their annotated locations for NP_001013331.1

    Status: PROVISIONAL

    Source sequence(s)
    BC090754
    UniProtKB/TrEMBL
    A0A8M3B857, F1RBZ6, Q5CZQ5
    Related
    ENSDARP00000075195.4, ENSDART00000080749.6
    Conserved Domains (2) summary
    cd09540
    Location:428 → 493
    SAM_EPS8-like; SAM domain of EPS8-like subfamily
    cd11764
    Location:283 → 336
    SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007114.7 Reference GRCz11 Primary Assembly

    Range
    16513226..16537441 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009299283.4 → XP_009297558.1  epidermal growth factor receptor kinase substrate 8-like protein 1a isoform X3

    UniProtKB/TrEMBL
    A0A8M3B0T2, A0A8M3B857, F1RBZ6
    Conserved Domains (2) summary
    cd09540
    Location:415 → 480
    SAM_EPS8-like; SAM domain of EPS8-like subfamily
    cd11764
    Location:270 → 323
    SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins

  2. XM_068216831.1 → XP_068072932.1  epidermal growth factor receptor kinase substrate 8-like protein 1a isoform X2

    UniProtKB/TrEMBL
    A0A8M3B857, F1RBZ6

  3. XM_021470513.2 → XP_021326188.2  epidermal growth factor receptor kinase substrate 8-like protein 1a isoform X1

    UniProtKB/TrEMBL
    A0A8M3B857, F1RBZ6

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394525.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    151814..177962 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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