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Tigar TP53 induced glycolysis regulatory phosphatase [ Rattus norvegicus (Norway rat) ]

Gene ID: 502894, updated on 27-Nov-2024

Summary

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Official Symbol
Tigarprovided by RGD
Official Full Name
TP53 induced glycolysis regulatory phosphataseprovided by RGD
Primary source
RGD:1560038
See related
EnsemblRapid:ENSRNOG00000051816 AllianceGenome:RGD:1560038
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable fructose-2,6-bisphosphate 2-phosphatase activity. Predicted to be involved in several processes, including cellular response to cobalt ion; positive regulation of phosphate metabolic process; and response to ischemia. Predicted to act upstream of or within several processes, including fructose 2,6-bisphosphate metabolic process; negative regulation of catabolic process; and positive regulation of cardiac muscle cell apoptotic process. Predicted to be located in cytosol; mitochondrial outer membrane; and nucleus. Orthologous to human TIGAR (TP53 induced glycolysis regulatory phosphatase). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Muscle (RPKM 115.6), Adrenal (RPKM 104.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Tigar in Genome Data Viewer
Location:
4q42
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (161613306..161632248, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (159927136..159946077, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (159635145..159654108, complement)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102547991 Neighboring gene fibroblast growth factor 23 Neighboring gene cyclin D2 Neighboring gene uncharacterized LOC108350761

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Metformin regulates the Th17/Treg balance by glycolysis with TIGAR in hepatic ischemia-reperfusion injury. Jiang A, et al. J Pharmacol Sci, 2021 May. PMID 33858654
  2. TIGAR suppresses seizures induced by kainic acid through inhibiting oxidative stress and neuronal apoptosis. Chen C, et al. Biochem Biophys Res Commun, 2019 Jul 30. PMID 31160088
  3. TIGAR impedes compression-induced intervertebral disc degeneration by suppressing nucleus pulposus cell apoptosis and autophagy. Li Z, et al. J Cell Physiol, 2020 Feb. PMID 31317559
  4. A TIGAR-regulated metabolic pathway is critical for protection of brain ischemia. Li M, et al. J Neurosci, 2014 May 28. PMID 24872551, Free PMC Article
  5. Mitochondrial localization of TIGAR under hypoxia stimulates HK2 and lowers ROS and cell death. Cheung EC, et al. Proc Natl Acad Sci U S A, 2012 Dec 11. PMID 23185017, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Metformin regulates the Th17/Treg balance by glycolysis with TIGAR in hepatic ischemia-reperfusion injury.
    Title: Metformin regulates the Th17/Treg balance by glycolysis with TIGAR in hepatic ischemia-reperfusion injury.
  2. TIGAR inhibits glycolysis in hypoxic myocytes and inhibition of glycolysis is closely involved in apoptosis, suggesting that TIGAR significantly mediates cellular energy homeostasis and cell death under ischemic stress.
    Title: p53 and TIGAR regulate cardiac myocyte energy homeostasis under hypoxic stress.
  3. TIGAR impedes compression-induced intervertebral disc degeneration by suppressing nucleus pulposus cell apoptosis and autophagy.
    Title: TIGAR impedes compression-induced intervertebral disc degeneration by suppressing nucleus pulposus cell apoptosis and autophagy.
  4. TIGAR has anti-epileptic, anti-oxidant and anti-apoptotic effects, and is therefore a promising therapeutictarget for epilepsy.
    Title: TIGAR suppresses seizures induced by kainic acid through inhibiting oxidative stress and neuronal apoptosis.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables fructose-2,6-bisphosphate 2-phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables fructose-2,6-bisphosphate 2-phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in DNA damage response ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of cardiac muscle cell apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to cobalt ion ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to hypoxia ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within fructose 2,6-bisphosphate metabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of glucose catabolic process to lactate via pyruvate ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of glycolytic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within intestinal epithelial cell development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of mitophagy ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of glucose catabolic process to lactate via pyruvate ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of glycolytic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within negative regulation of glycolytic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of mitophagy ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of programmed cell death ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of reactive oxygen species metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA repair ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of cardiac muscle cell apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of hexokinase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of pentose-phosphate shunt ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of reactive oxygen species metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of pentose-phosphate shunt IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of pentose-phosphate shunt ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of response to DNA damage checkpoint signaling ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within response to gamma radiation ISO
Inferred from Sequence Orthology
more info
  
involved_in response to ischemia ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within response to xenobiotic stimulus ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial outer membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
fructose-2,6-bisphosphatase TIGAR
Names
TP53-induced glycolysis and apoptosis regulator
NP_001020235.1
NP_001381980.1
XP_038964186.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001025064.2 → NP_001020235.1  fructose-2,6-bisphosphatase TIGAR isoform 2

    See identical proteins and their annotated locations for NP_001020235.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/TrEMBL
    A0A8I6A442, Q566D2
    Conserved Domains (1) summary
    cl11399
    Location:2 → 151
    HP; Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction

  2. NM_001395051.1 → NP_001381980.1  fructose-2,6-bisphosphatase TIGAR isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/TrEMBL
    A0A0G2K8S8, A0A8I6AIY8, A6ILX2
    Related
    ENSRNOP00000074722.3, ENSRNOT00000091662.3
    Conserved Domains (1) summary
    pfam00300
    Location:6 → 241
    His_Phos_1; Histidine phosphatase superfamily (branch 1)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    161613306..161632248 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039108258.2 → XP_038964186.1  fructose-2,6-bisphosphatase TIGAR isoform X1

    UniProtKB/TrEMBL
    A0A8I6A442, Q566D2
    Conserved Domains (1) summary
    cl11399
    Location:2 → 151
    HP; Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction
Nucleotide Protein Strain
Heading Accession and Version

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