Bola2 bolA family member 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Bola2provided by RGD
Official Full Name: bolA family member 2provided by RGD
Primary source: RGD:1565363
See related: EnsemblRapid:ENSRNOG00000047988 AllianceGenome:RGD:1565363
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1565363
Summary: Predicted to enable iron-sulfur cluster binding activity. Predicted to be involved in several processes, including [2Fe-2S] cluster assembly; cell redox homeostasis; and protein maturation by iron-sulfur cluster transfer. Predicted to be located in cytoplasm. Predicted to be part of iron-sulfur cluster assembly complex. Predicted to be active in cytosol and nucleus. Orthologous to several human genes including BOLA2 (bolA family member 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Thymus (RPKM 261.4), Kidney (RPKM 227.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q36

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (190722535..190723401)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (181291967..181292833)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (198120104..198121158)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 2 iron, 2 sulfur cluster binding	IEA Inferred from Electronic Annotation more info
enables iron-sulfur cluster binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in [2Fe-2S] cluster assembly	ISO Inferred from Sequence Orthology more info
involved_in cell redox homeostasis	ISO Inferred from Sequence Orthology more info
involved_in intracellular iron ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular iron ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in iron-sulfur cluster assembly	ISO Inferred from Sequence Orthology more info
involved_in protein maturation by iron-sulfur cluster transfer	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
part_of iron-sulfur cluster assembly complex	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: bolA family member 2

Names: bolA-like protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.