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ND-B8 NADH dehydrogenase (ubiquinone) B8 subunit [ Drosophila melanogaster (fruit fly) ]

Gene ID: 50178, updated on 9-Dec-2024

Summary

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Official Symbol
ND-B8provided by FlyBase
Official Full Name
NADH dehydrogenase (ubiquinone) B8 subunitprovided by FlyBase
Primary source
FLYBASE:FBgn0040705
Locus tag
Dmel_CG15434
See related
AllianceGenome:FB:FBgn0040705
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG15434; Dmel\CG15434; dNDUFA2; NDUFA2; NI8M
Summary
Predicted to be involved in mitochondrial respiratory chain complex I assembly. Predicted to be part of respiratory chain complex I. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency 13. Orthologous to human NDUFA2 (NADH:ubiquinone oxidoreductase subunit A2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See ND-B8 in Genome Data Viewer
Location:
24F3-24F3; 2-12 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (4454626..4455207)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (4454626..4455207)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene tRNA Selenocysteine associated protein Neighboring gene GS1-like Neighboring gene ncRNA Neighboring gene Ribosomal protein L27A Neighboring gene mitochondrial ribosomal protein L27

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Transcriptome analysis of a long-lived natural Drosophila variant: a prominent role of stress- and reproduction-genes in lifespan extension. Doroszuk A, et al. BMC Genomics, 2012 May 4. PMID 22559237, Free PMC Article
  2. Identification of a mitochondrial target of thiazolidinedione insulin sensitizers (mTOT)--relationship to newly identified mitochondrial pyruvate carrier proteins. Colca JR, et al. PLoS One, 2013. PMID 23690925, Free PMC Article
  3. Phenotypic plasticity and genotype by environment interaction for olfactory behavior in Drosophila melanogaster. Sambandan D, et al. Genetics, 2008 Jun. PMID 18505870, Free PMC Article
  4. Resting mitochondrial complex I from Drosophila melanogaster adopts a helix-locked state. Padavannil A, et al. Elife, 2023 Mar 23. PMID 36952377, Free PMC Article
  5. Mitochondrial dysfunction reveals the role of mRNA poly(A) tail regulation in oculopharyngeal muscular dystrophy pathogenesis. Chartier A, et al. PLoS Genet, 2015 Mar. PMID 25816335, Free PMC Article

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in mitochondrial respiratory chain complex I assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in mitochondrial inner membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of respiratory chain complex I IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of respiratory chain complex I ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
NADH dehydrogenase (ubiquinone) B8 subunit
Names
CG15434-PA
NADH ubiquinone oxidoreductase B8
NADH-ubiquinone oxidoreductase B8 subunit
NADH:ubiquinone oxidoreductase B8 subunit
ND-B8-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    4454626..4455207
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_144084.3 → NP_652341.1  NADH dehydrogenase (ubiquinone) B8 subunit [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_652341.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VR00
    Related
    FBpp0077130
    Conserved Domains (1) summary
    smart00916
    Location:29 → 93
    L51_S25_CI-B8; Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VR00 Q9VR00

Gene LinkOut

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