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Teh3 tipE homolog 3 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 50170, updated on 9-Dec-2024

Summary

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Official Symbol
Teh3provided by FlyBase
Official Full Name
tipE homolog 3provided by FlyBase
Primary source
FLYBASE:FBgn0040697
Locus tag
Dmel_CG18676
See related
AllianceGenome:FB:FBgn0040697
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG18676; Dmel\CG18676; TEH1; TEH3
Summary
Enables sodium channel regulator activity. Involved in regulation of sodium ion transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Teh3 in Genome Data Viewer
Location:
64A10-64A10; 3-10 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (4182645..4184663, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (4182645..4184663, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Endoplasmic reticulum oxidoreductin-1-like Neighboring gene uncharacterized protein Neighboring gene tipE homolog 4 Neighboring gene tipE homolog 2 Neighboring gene Vacuolar H[+] ATPase M9.7 subunit c Neighboring gene temperature-induced paralytic E

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Distinct modulating effects of TipE-homologs 2-4 on Drosophila sodium channel splice variants. Wang L, et al. Insect Biochem Mol Biol, 2015 May. PMID 25744892
  2. A remarkably stable TipE gene cluster: evolution of insect Para sodium channel auxiliary subunits. Li J, et al. BMC Evol Biol, 2011 Nov 18. PMID 22098672, Free PMC Article
  3. Four novel sequences in Drosophila melanogaster homologous to the auxiliary Para sodium channel subunit TipE. Derst C, et al. Biochem Biophys Res Commun, 2006 Jan 20. PMID 16325765
  4. Investigating Developmental and Epileptic Encephalopathy Using Drosophila melanogaster. Takai A, et al. Int J Mol Sci, 2020 Sep 3. PMID 32899411, Free PMC Article
  5. Drosophila CLOCK target gene characterization: implications for circadian tissue-specific gene expression. Abruzzi KC, et al. Genes Dev, 2011 Nov 15. PMID 22085964, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. inhibited the sodium current decay and increased the persistent current of three DmNav variants
    Title: Distinct modulating effects of TipE-homologs 2-4 on Drosophila sodium channel splice variants.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables sodium channel regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sodium channel regulator activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of sodium ion transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of sodium ion transport IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane ISM
Inferred from Sequence Model
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
tipE homolog 3
Names
CG18676-PA
Teh3-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    4182645..4184663 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_144078.2 → NP_652335.1  tipE homolog 3 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_652335.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C9QPH5, Q9VZG8
    Related
    FBpp0073113
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VZG8 Q9VZG8

Gene LinkOut

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