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Trappc2 trafficking protein particle complex subunit 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 501550, updated on 4-Jan-2025

Summary

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Official Symbol
Trappc2provided by RGD
Official Full Name
trafficking protein particle complex subunit 2provided by RGD
Primary source
RGD:1306925
See related
EnsemblRapid:ENSRNOG00000042276 AllianceGenome:RGD:1306925
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1306925
Summary
Predicted to enable transcription corepressor binding activity; transcription regulator inhibitor activity; and transmembrane transporter binding activity. Predicted to be involved in endoplasmic reticulum to Golgi vesicle-mediated transport; positive regulation of gene expression; and skeletal system development. Predicted to be located in endoplasmic reticulum; nucleus; and perinuclear region of cytoplasm. Predicted to be part of TRAPP complex. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in X-linked spondyloepiphyseal dysplasia tarda. Orthologous to several human genes including TRAPPC2 (trafficking protein particle complex subunit 2). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Brain (RPKM 226.5), Lung (RPKM 101.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Trappc2 in Genome Data Viewer
Location:
Xq13
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (31617107..31647035, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (28004051..28015336, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (29550871..29562135, complement)

Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene transcription elongation factor A N-terminal and central domain containing Neighboring gene stabilizer of axonemal microtubules like 1 Neighboring gene RAB9A, member RAS oncogene family Neighboring gene Ofd1 centriole and centriolar satellite protein Neighboring gene glycoprotein m6b Neighboring gene gem (nuclear organelle) associated protein 8

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Identification of the gene (SEDL) causing X-linked spondyloepiphyseal dysplasia tarda. Gedeon AK, et al. Nat Genet, 1999 Aug. PMID 10431248
  2. Interaction of Sedlin with chloride intracellular channel proteins. Fan L, et al. FEBS Lett, 2003 Apr 10. PMID 12681486
  3. A novel 16-kilodalton cellular protein physically interacts with and antagonizes the functional activity of c-myc promoter-binding protein 1. Ghosh AK, et al. Mol Cell Biol, 2001 Jan. PMID 11134351, Free PMC Article
  4. TRAMM/TrappC12 plays a role in chromosome congression, kinetochore stability, and CENP-E recruitment. Milev MP, et al. J Cell Biol, 2015 Apr 27. PMID 25918224, Free PMC Article
  5. mBET3 is required for the organization of the TRAPP complexes. Menon S, et al. Biochem Biophys Res Commun, 2006 Nov 24. PMID 17027922

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC109621

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables transcription corepressor binding ISO
Inferred from Sequence Orthology
more info
  
enables transcription regulator inhibitor activity ISO
Inferred from Sequence Orthology
more info
  
enables transmembrane transporter binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
involved_in skeletal system development ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of TRAPP complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of TRAPP complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear outer membrane ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
trafficking protein particle complex subunit 2
Names
sedlin
trafficking protein particle complex 2
trafficking protein particle complex protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001024965.1 → NP_001020136.1  trafficking protein particle complex subunit 2

    See identical proteins and their annotated locations for NP_001020136.1

    Status: PROVISIONAL

    Source sequence(s)
    BC091429
    UniProtKB/TrEMBL
    A6K2H9, A6K2I0, Q5BJL8
    Related
    ENSRNOP00000062350.1, ENSRNOT00000068113.3
    Conserved Domains (1) summary
    cd14825
    Location:4 → 138
    TRAPPC2_sedlin; Trafficking protein particle complex subunit 2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086039.1 Reference GRCr8

    Range
    31617107..31647035 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063280240.1 → XP_063136310.1  trafficking protein particle complex subunit 2 isoform X1

    UniProtKB/TrEMBL
    A6K2H9, A6K2I0, Q5BJL8

  2. XM_063280241.1 → XP_063136311.1  trafficking protein particle complex subunit 2 isoform X1

    UniProtKB/TrEMBL
    A6K2H9, A6K2I0, Q5BJL8

RNA

  1. XR_010061223.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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