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Lrrc14 leucine rich repeat containing 14 [ Rattus norvegicus (Norway rat) ]

Gene ID: 500900, updated on 27-Nov-2024

Summary

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Official Symbol
Lrrc14provided by RGD
Official Full Name
leucine rich repeat containing 14provided by RGD
Primary source
RGD:1560202
See related
EnsemblRapid:ENSRNOG00000016128 AllianceGenome:RGD:1560202
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable kinase binding activity. Predicted to be involved in negative regulation of NF-kappaB transcription factor activity and negative regulation of toll-like receptor signaling pathway. Predicted to be active in cytoplasm. Orthologous to human LRRC14 (leucine rich repeat containing 14). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Adrenal (RPKM 65.6), Kidney (RPKM 62.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Lrrc14 in Genome Data Viewer
Location:
7q34
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (110311384..110317757)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (108430755..108437118)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (117773219..117779555)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene glutamic--pyruvic transaminase Neighboring gene major facilitator superfamily domain containing 3 Neighboring gene RecQ like helicase 4 Neighboring gene leucine rich repeat containing 24 Neighboring gene similar to human chromosome 8 open reading frame 82 Neighboring gene Rho GTPase activating protein 39

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. LRRC14 attenuates Toll-like receptor-mediated NF-κB signaling through disruption of IKK complex. Wu C, et al. Exp Cell Res, 2016 Sep 10. PMID 27426725
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC108882

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables kinase binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in negative regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of NF-kappaB transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of toll-like receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of toll-like receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of toll-like receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of toll-like receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
leucine-rich repeat-containing protein 14

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001024354.1 → NP_001019525.1  leucine-rich repeat-containing protein 14 isoform 2

    See identical proteins and their annotated locations for NP_001019525.1

    Status: PROVISIONAL

    Source sequence(s)
    BC092583
    UniProtKB/Swiss-Prot
    Q569B5
    UniProtKB/TrEMBL
    A0A8L2UJL0
    Conserved Domains (3) summary
    sd00031
    Location:311 → 337
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:286 → 309
    LRR_RI; leucine-rich repeat [structural motif]
    cl39015
    Location:221 → 414
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

  2. NM_001401224.1 → NP_001388153.1  leucine-rich repeat-containing protein 14 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/TrEMBL
    A0A0G2JUP6
    Related
    ENSRNOP00000069176.1, ENSRNOT00000077562.3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    110311384..110317757
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063264131.1 → XP_063120201.1  leucine-rich repeat-containing protein 14 isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZZT2

  2. XM_006241862.5 → XP_006241924.1  leucine-rich repeat-containing protein 14 isoform X3

    See identical proteins and their annotated locations for XP_006241924.1

    UniProtKB/Swiss-Prot
    Q569B5
    UniProtKB/TrEMBL
    A0A8L2UJL0
    Conserved Domains (3) summary
    sd00031
    Location:311 → 337
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:286 → 309
    LRR_RI; leucine-rich repeat [structural motif]
    cl39015
    Location:221 → 414
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

  3. XM_039079759.2 → XP_038935687.1  leucine-rich repeat-containing protein 14 isoform X1

    UniProtKB/TrEMBL
    A0A8L2UJL0
    Conserved Domains (3) summary
    sd00031
    Location:354 → 380
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:329 → 352
    LRR_RI; leucine-rich repeat [structural motif]
    cl39015
    Location:264 → 457
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

  4. XM_063264130.1 → XP_063120200.1  leucine-rich repeat-containing protein 14 isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZZT2
    Related
    ENSRNOP00000083734.1, ENSRNOT00000097197.2

  5. XM_063264128.1 → XP_063120198.1  leucine-rich repeat-containing protein 14 isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZZT2

  6. XM_063264132.1 → XP_063120202.1  leucine-rich repeat-containing protein 14 isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZZT2

  7. XM_039079758.2 → XP_038935686.1  leucine-rich repeat-containing protein 14 isoform X1

    UniProtKB/TrEMBL
    A0A8L2UJL0
    Related
    ENSRNOP00000098700.1, ENSRNOT00000173835.1
    Conserved Domains (3) summary
    sd00031
    Location:354 → 380
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:329 → 352
    LRR_RI; leucine-rich repeat [structural motif]
    cl39015
    Location:264 → 457
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

  8. XM_063264133.1 → XP_063120203.1  leucine-rich repeat-containing protein 14 isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZZT2
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q569B5.1 GenPept UniProtKB/Swiss-Prot:Q569B5

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