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FHY1 far-red elongated hypocotyl 1 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 5007942, updated on 18-Sep-2024

Summary

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Official Symbol
FHY1
Official Full Name
far-red elongated hypocotyl 1
Primary source
TAIR:AT2G37678
Locus tag
AT2G37678
See related
Araport:AT2G37678
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
far-red elongated hypocotyl 1; FAR-RED ELONGATED HYPOCOTYL 1; FRY1; PAT3; PHYTOCHROME A SIGNAL TRANSDUCTION 3
Summary
Positive regulator of photomorphogenesis in far-red light. Most abundant in young seedlings in the dark. Downregulated in the light and older as plants develop. Localized in the nucleus and the cytoplasm. Nuclear localization strongest in the dark. Degraded through the 26S proteasome. Regulated by PHYA. It is specifically required for the light-regulated nuclear accumulation of phyA but not phyB.
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Genomic context

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See FHY1 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
3
Sequence:
Chromosome: 2; NC_003071.7 (15801418..15802793, complement)

Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene GRAS family transcription factor Neighboring gene NAD(P)-binding Rossmann-fold superfamily protein Neighboring gene Transducin/WD40 repeat-like superfamily protein Neighboring gene glucose-induced degradation-like protein Neighboring gene phosphoribosylaminoimidazole carboxylase, putative / AIR carboxylase Neighboring gene Fatty acid hydroxylase superfamily

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Arabidopsis phytochrome A nuclear translocation is mediated by a far-red elongated hypocotyl 1-importin complex. Helizon H, et al. Plant J, 2018 Dec. PMID 30256472
  2. The phytochrome A specific signaling component PAT3 is a positive regulator of Arabidopsis photomorphogenesis. Zeidler M, et al. Plant Cell Physiol, 2001 Nov. PMID 11726703
  3. A novel fry1 allele reveals the existence of a mutant phenotype unrelated to 5'->3' exoribonuclease (XRN) activities in Arabidopsis thaliana roots. Hirsch J, et al. PLoS One, 2011 Feb 3. PMID 21304819, Free PMC Article
  4. A cell-free system for light-dependent nuclear import of phytochrome. Pfeiffer A, et al. Plant J, 2009 Feb. PMID 18980642
  5. Reversible SUMOylation of FHY1 Regulates Phytochrome A Signaling in Arabidopsis. Qu GP, et al. Mol Plant, 2020 Jun 1. PMID 32298785

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Arabidopsis FHY1 and FHY1-LIKE Are Not Required for Phytochrome A Signal Transduction in the Nucleus.
    Title: Arabidopsis FHY1 and FHY1-LIKE Are Not Required for Phytochrome A Signal Transduction in the Nucleus.
  2. Reversible SUMOylation of FHY1 Regulates Phytochrome A Signaling in Arabidopsis.
    Title: Reversible SUMOylation of FHY1 Regulates Phytochrome A Signaling in Arabidopsis.
  3. mediates phytochrome A nuclear translocation
    Title: Arabidopsis phytochrome A nuclear translocation is mediated by a far-red elongated hypocotyl 1-importin complex.
  4. nuclear FHY1 can either act independently of phyA or act in association with phyA to activate the expression of distinct target genes
    Title: Photoreceptor partner FHY1 has an independent role in gene modulation and plant development under far-red light.
  5. Results reveal FHY1 phosphorylation as a key mechanism for FR/R spectrum-specific responses in plants and an essential event for plant adaption to changing light conditions in nature.
    Title: Phosphorylation of FAR-RED ELONGATED HYPOCOTYL1 is a key mechanism defining signaling dynamics of phytochrome A under red and far-red light in Arabidopsis.
  6. 3',(2'),5'-bisphosphate nucleotide phosphatase activity of FRY1 is involved in long-distance as well as local regulatory activities in roots.
    Title: A novel fry1 allele reveals the existence of a mutant phenotype unrelated to 5'->3' exoribonuclease (XRN) activities in Arabidopsis thaliana roots.
  7. The phosphorylation of FHY1 depends on functioning phytochrome A.
    Title: Phytochrome A mediates rapid red light-induced phosphorylation of Arabidopsis FAR-RED ELONGATED HYPOCOTYL1 in a low fluence response.
  8. FHY1 and FHL work as adaptor proteins facilitating nuclear transport of phyA.
    Title: FHY1 mediates nuclear import of the light-activated phytochrome A photoreceptor.
  9. phyA associations with FHY3 and FHY1 protect underphosphorylated phyA from being recognized by the COP1/SPA complex.
    Title: Arabidopsis COP1/SPA1 complex and FHY1/FHY3 associate with distinct phosphorylated forms of phytochrome A in balancing light signaling.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_001084549.2
NM_001336669.1

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables nuclear import signal receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within far-red light signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within maintenance of protein location in nucleus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within photomorphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of response to salt stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of seed germination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulatory ncRNA-mediated heterochromatin formation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to absence of light IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to far red light IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within response to far red light IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within response to far red light IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to far red light IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to light stimulus IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to red light IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to red or far red light IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISM
Inferred from Sequence Model
more info
  
located_in nucleus TAS
Traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
far-red elongated hypocotyl 1
NP_001078018.1
  • far-red elongated hypocotyl 1 (FHY1); FUNCTIONS IN: transcription regulator activity; INVOLVED IN: maintenance of protein location in nucleus, response to red or far red light, response to far red light, photomorphogenesis; LOCATED IN: nuclear body, nucleus, cytoplasm; EXPRESSED IN: hypocotyl; BEST Arabidopsis thaliana protein match is: far-red-elongated hypocotyl1-like (TAIR:AT5G02200.2); Has 30 Blast hits to 30 proteins in 8 species: Archae - 0; Bacteria - 0; Metazoa - 0; Fungi - 0; Plants - 30; Viruses - 0; Other Eukaryotes - 0 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003071.7 Reference assembly

    Range
    15801418..15802793 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001084549.2 → NP_001078018.1  far-red elongated hypocotyl 1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001078018.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D5MAD1, D5MAD2, O80936, Q7Y200, Q8S4Q6, Q8W565
    UniProtKB/TrEMBL
    A0A178VY82, A0A5S9X4X2, A0A654F509
    Conserved Domains (1) summary
    PLN03104
    Location:4 → 202
    FHL; FAR-RED-ELONGATED HYPOCOTYL1-LIKE; Provisional

  2. NM_001336669.1 → NP_001323653.1  far-red elongated hypocotyl 1 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178VY82
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8S4Q6.1

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