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Ccnk cyclin K [ Rattus norvegicus (Norway rat) ]

Gene ID: 500715, updated on 27-Nov-2024

Summary

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Official Symbol
Ccnkprovided by RGD
Official Full Name
cyclin Kprovided by RGD
Primary source
RGD:1595690
See related
EnsemblRapid:ENSRNOG00000006985 AllianceGenome:RGD:1595690
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable cyclin-dependent protein serine/threonine kinase activator activity; protein kinase binding activity; and protein serine/threonine kinase activity. Predicted to be involved in several processes, including negative regulation by host of viral genome replication; positive regulation of transcription elongation by RNA polymerase II; and transcription by RNA polymerase II. Predicted to act upstream of or within DNA damage response; in utero embryonic development; and negative regulation of stem cell differentiation. Predicted to be located in nucleoplasm. Predicted to be part of cyclin K-CDK12 complex; cyclin K-CDK13 complex; and cyclin/CDK positive transcription elongation factor complex. Predicted to be active in nucleus. Orthologous to human CCNK (cyclin K). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Testes (RPKM 60.1), Spleen (RPKM 47.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ccnk in Genome Data Viewer
Location:
6q32
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (132854428..132877604)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (127090115..127113195)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (132090235..132113560)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene BCL11 transcription factor B Neighboring gene uncharacterized LOC103692702 Neighboring gene SET domain containing 3, actin N3(tau)-histidine methyltransferase Neighboring gene uncharacterized LOC120103617 Neighboring gene coiled-coil domain containing 85C Neighboring gene uncharacterized LOC120103618

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Interaction of cyclin-dependent kinase 12/CrkRS with cyclin K1 is required for the phosphorylation of the C-terminal domain of RNA polymerase II. Cheng SW, et al. Mol Cell Biol, 2012 Nov. PMID 22988298, Free PMC Article
  2. Cyclin K inhibits HIV-1 gene expression and replication by interfering with cyclin-dependent kinase 9 (CDK9)-cyclin T1 interaction in Nef-dependent manner. Khan SZ, et al. J Biol Chem, 2011 Jul 1. PMID 21555514, Free PMC Article
  3. The Cyclin K/Cdk12 complex maintains genomic stability via regulation of expression of DNA damage response genes. Blazek D, et al. Genes Dev, 2011 Oct 15. PMID 22012619, Free PMC Article
  4. Human cyclin K, a novel RNA polymerase II-associated cyclin possessing both carboxy-terminal domain kinase and Cdk-activating kinase activity. Edwards MC, et al. Mol Cell Biol, 1998 Jul. PMID 9632813, Free PMC Article
  5. Cyclin K-containing kinase complexes maintain self-renewal in murine embryonic stem cells. Dai Q, et al. J Biol Chem, 2012 Jul 20. PMID 22547058, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables RNA polymerase II CTD heptapeptide repeat kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables cyclin-dependent protein serine/threonine kinase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cyclin-dependent protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response ISO
Inferred from Sequence Orthology
more info
  
involved_in biological_process ND
No biological Data available
more info
  
acts_upstream_of_or_within in utero embryonic development ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation by host of viral genome replication ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of stem cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA-templated transcription, elongation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of transcription elongation by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of cyclin K-CDK12 complex ISO
Inferred from Sequence Orthology
more info
  
part_of cyclin K-CDK13 complex ISO
Inferred from Sequence Orthology
more info
  
part_of cyclin/CDK positive transcription elongation factor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
cyclin-K

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001109672.1 → NP_001103142.1  cyclin-K

    See identical proteins and their annotated locations for NP_001103142.1

    Status: PROVISIONAL

    Source sequence(s)
    BC129121
    UniProtKB/TrEMBL
    A1L1L5, F7EZL5
    Conserved Domains (2) summary
    cd20530
    Location:40 → 154
    CYCLIN_CCNK_rpt1; first cyclin box found in cyclin-K (CCNK) and similar proteins
    cd20531
    Location:158 → 258
    CYCLIN_CCNK_rpt2; second cyclin box found in cyclin-K (CCNK) and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    132854428..132877604
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006240549.5 → XP_006240611.1  cyclin-K isoform X1

    See identical proteins and their annotated locations for XP_006240611.1

    UniProtKB/TrEMBL
    A1L1L5, F7EZL5
    Conserved Domains (2) summary
    cd20530
    Location:40 → 154
    CYCLIN_CCNK_rpt1; first cyclin box found in cyclin-K (CCNK) and similar proteins
    cd20531
    Location:158 → 258
    CYCLIN_CCNK_rpt2; second cyclin box found in cyclin-K (CCNK) and similar proteins

  2. XM_063262339.1 → XP_063118409.1  cyclin-K isoform X1

    UniProtKB/TrEMBL
    A1L1L5

  3. XM_063262340.1 → XP_063118410.1  cyclin-K isoform X1

    UniProtKB/TrEMBL
    A1L1L5
    Related
    ENSRNOP00000074580.1, ENSRNOT00000083208.3

  4. XM_063262341.1 → XP_063118411.1  cyclin-K isoform X1

    UniProtKB/TrEMBL
    A1L1L5

  5. XM_039112762.2 → XP_038968690.1  cyclin-K isoform X1

    UniProtKB/TrEMBL
    A1L1L5, F7EZL5
    Conserved Domains (2) summary
    cd20530
    Location:40 → 154
    CYCLIN_CCNK_rpt1; first cyclin box found in cyclin-K (CCNK) and similar proteins
    cd20531
    Location:158 → 258
    CYCLIN_CCNK_rpt2; second cyclin box found in cyclin-K (CCNK) and similar proteins

  6. XM_006240551.5 → XP_006240613.1  cyclin-K isoform X1

    See identical proteins and their annotated locations for XP_006240613.1

    UniProtKB/TrEMBL
    A1L1L5, F7EZL5
    Conserved Domains (2) summary
    cd20530
    Location:40 → 154
    CYCLIN_CCNK_rpt1; first cyclin box found in cyclin-K (CCNK) and similar proteins
    cd20531
    Location:158 → 258
    CYCLIN_CCNK_rpt2; second cyclin box found in cyclin-K (CCNK) and similar proteins
Nucleotide Protein Strain
Heading Accession and Version

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