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Efcab11 EF-hand calcium binding domain 11 [ Rattus norvegicus (Norway rat) ]

Gene ID: 500705, updated on 4-Jan-2025

Summary

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Official Symbol
Efcab11provided by RGD
Official Full Name
EF-hand calcium binding domain 11provided by RGD
Primary source
RGD:1565006
See related
EnsemblRapid:ENSRNOG00000053317 AllianceGenome:RGD:1565006
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable calcium ion binding activity and enzyme regulator activity. Predicted to be involved in microtubule cytoskeleton organization. Predicted to be active in cytoplasm. Orthologous to human EFCAB11 (EF-hand calcium binding domain 11). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Testes (RPKM 12.1), Thymus (RPKM 3.8) and 6 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Efcab11 in Genome Data Viewer
Location:
6q32
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (124738531..124892623, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (119008908..119162994, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (123742971..123894714, complement)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene forkhead box N3 Neighboring gene uncharacterized LOC102550560 Neighboring gene uncharacterized LOC108351290 Neighboring gene uncharacterized LOC120103598 Neighboring gene tyrosyl-DNA phosphodiesterase 1 Neighboring gene potassium two pore domain channel subfamily K member 13 Neighboring gene uncharacterized LOC120103599

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Novel candidate genes for impaired nephron development in a rat model with inherited nephron deficit and albuminuria. Herlan L, et al. Clin Exp Pharmacol Physiol, 2015 Oct. PMID 26192016
  2. The novel testicular enrichment protein Cfap58 is required for Notch-associated ciliogenesis. Li ZZ, et al. Biosci Rep, 2020 Jan 31. PMID 31904090, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables enzyme regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
EF-hand calcium-binding domain-containing protein 11
Names
EF-hand domain-containing protein C14orf143 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001024350.1 → NP_001019521.1  EF-hand calcium-binding domain-containing protein 11

    See identical proteins and their annotated locations for NP_001019521.1

    Status: PROVISIONAL

    Source sequence(s)
    BC079408
    UniProtKB/Swiss-Prot
    Q6AXQ2
    UniProtKB/TrEMBL
    A6JEG2, A6JEG3
    Related
    ENSRNOP00000069648.1, ENSRNOT00000082444.3
    Conserved Domains (3) summary
    cd00051
    Location:95 → 152
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam13499
    Location:96 → 156
    EF-hand_7; EF-hand domain pair
    cl08302
    Location:25 → 84
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    124738531..124892623 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039112741.1 → XP_038968669.1  EF-hand calcium-binding domain-containing protein 11 isoform X1

    Conserved Domains (1) summary
    COG5126
    Location:3 → 104
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

  2. XM_039112742.2 → XP_038968670.1  EF-hand calcium-binding domain-containing protein 11 isoform X1

    Conserved Domains (1) summary
    COG5126
    Location:3 → 104
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

  3. XM_039112743.2 → XP_038968671.1  EF-hand calcium-binding domain-containing protein 11 isoform X2

    Conserved Domains (1) summary
    pfam13499
    Location:30 → 93
    EF-hand_7; EF-hand domain pair
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6AXQ2.1 GenPept UniProtKB/Swiss-Prot:Q6AXQ2

Gene LinkOut

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