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Rnf144a ring finger protein 144A [ Rattus norvegicus (Norway rat) ]

Gene ID: 500636, updated on 4-Jan-2025

Summary

Official Symbol
Rnf144aprovided by RGD
Official Full Name
ring finger protein 144Aprovided by RGD
Primary source
RGD:1561737
See related
EnsemblRapid:ENSRNOG00000007370 AllianceGenome:RGD:1561737
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Rnf144; RGD1561737
Summary
Predicted to enable ubiquitin conjugating enzyme binding activity and ubiquitin protein ligase activity. Predicted to be involved in pattern recognition receptor signaling pathway; protein K6-linked ubiquitination; and ubiquitin-dependent protein catabolic process. Predicted to be located in intracellular membrane-bounded organelle. Predicted to be part of ubiquitin ligase complex. Predicted to be active in Golgi apparatus and endoplasmic reticulum membrane. Orthologous to human RNF144A (ring finger protein 144A). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Lung (RPKM 99.0), Heart (RPKM 66.3) and 9 other tissues See more
Orthologs
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Genomic context

See Rnf144a in Genome Data Viewer
Location:
6q16
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (48628241..48748241, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (42899767..43019769, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (45509895..45629233, complement)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120093243 Neighboring gene phosphoglycerate dehydrogenase, pseudogene 6 Neighboring gene uncharacterized LOC134479352 Neighboring gene radical S-adenosyl methionine domain containing 2

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ubiquitin conjugating enzyme binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in pattern recognition receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in protein K6-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
part_of ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
E3 ubiquitin-protein ligase RNF144A
Names
probable E3 ubiquitin-protein ligase RNF144A
ring finger protein 144
NP_001075879.1
XP_038968637.1
XP_038968638.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001082410.1NP_001075879.1  E3 ubiquitin-protein ligase RNF144A

    See identical proteins and their annotated locations for NP_001075879.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000006
    UniProtKB/TrEMBL
    A0A8I6AFP4, A6HAZ8, D3ZYY5
    Related
    ENSRNOP00000009877.4, ENSRNOT00000009877.8
    Conserved Domains (3) summary
    smart00647
    Location:91156
    IBR; In Between Ring fingers
    cd16777
    Location:1972
    mRING-HC-C4C4_RBR_RNF144A; Modified RING finger, HC subclass (C4C4-type), found in RING finger protein 144A (RNF144A)
    pfam01485
    Location:179216
    IBR; IBR domain, a half RING-finger domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    48628241..48748241 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039112710.2XP_038968638.1  E3 ubiquitin-protein ligase RNF144A isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZNS4, A0A8I6AFP4
    Related
    ENSRNOP00000079847.1, ENSRNOT00000118759.2
    Conserved Domains (3) summary
    smart00647
    Location:71136
    IBR; In Between Ring fingers
    pfam01485
    Location:159196
    IBR; IBR domain, a half RING-finger domain
    cl17238
    Location:2652
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
  2. XM_039112709.2XP_038968637.1  E3 ubiquitin-protein ligase RNF144A isoform X1

    UniProtKB/TrEMBL
    A0A8I6AFP4, A6HAZ8, D3ZYY5
    Conserved Domains (3) summary
    smart00647
    Location:91156
    IBR; In Between Ring fingers
    cd16777
    Location:1972
    mRING-HC-C4C4_RBR_RNF144A; Modified RING finger, HC subclass (C4C4-type), found in RING finger protein 144A (RNF144A)
    pfam01485
    Location:179216
    IBR; IBR domain, a half RING-finger domain