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Fbxo44 F-box protein 44 [ Rattus norvegicus (Norway rat) ]

Gene ID: 500587, updated on 27-Nov-2024

Summary

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Official Symbol
Fbxo44provided by RGD
Official Full Name
F-box protein 44provided by RGD
Primary source
RGD:1562463
See related
EnsemblRapid:ENSRNOG00000009298 AllianceGenome:RGD:1562463
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1562463
Summary
Predicted to contribute to ubiquitin protein ligase activity. Predicted to be involved in ERAD pathway; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; and glycoprotein catabolic process. Predicted to act upstream of or within proteasomal protein catabolic process. Predicted to be part of SCF ubiquitin ligase complex. Predicted to be active in cytoplasm. Orthologous to human FBXO44 (F-box protein 44). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 270.2), Adrenal (RPKM 154.7) and 7 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Fbxo44 in Genome Data Viewer
Location:
5q36
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (163866517..163875928, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (158583363..158592510, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (164962921..164972273, complement)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene mitotic arrest deficient 2 like 2 Neighboring gene F-box protein 6 Neighboring gene F-box protein 2 Neighboring gene uncharacterized LOC108351059

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Diversity in tissue expression, substrate binding, and SCF complex formation for a lectin family of ubiquitin ligases. Glenn KA, et al. J Biol Chem, 2008 May 9. PMID 18203720, Free PMC Article
  2. FBXO44-Mediated Degradation of RGS2 Protein Uniquely Depends on a Cullin 4B/DDB1 Complex. Sjögren B, et al. PLoS One, 2015. PMID 25970626, Free PMC Article
  3. Maturation of human dendritic cells is accompanied by functional remodelling of the ubiquitin-proteasome system. Ebstein F, et al. Int J Biochem Cell Biol, 2009 May. PMID 19028597
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
contributes_to ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in ERAD pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glycoprotein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within proteasomal protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of SCF ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of SCF ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
F-box only protein 44

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001191576.1 → NP_001178505.1  F-box only protein 44

    See identical proteins and their annotated locations for NP_001178505.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/TrEMBL
    D4A6R1
    Conserved Domains (2) summary
    pfam04300
    Location:72 → 250
    FBA; F-box associated region
    pfam12937
    Location:6 → 51
    F-box-like

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    163866517..163875928 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063288302.1 → XP_063144372.1  F-box only protein 44 isoform X6

    UniProtKB/TrEMBL
    A0A8I6A0Z6

  2. XM_006239398.5 → XP_006239460.2  F-box only protein 44 isoform X5

    Conserved Domains (2) summary
    pfam04300
    Location:86 → 136
    FBA; F-box associated region
    pfam12937
    Location:20 → 67
    F-box-like; F-box-like

  3. XM_063288301.1 → XP_063144371.1  F-box only protein 44 isoform X3

  4. XM_063288303.1 → XP_063144373.1  F-box only protein 44 isoform X6

    UniProtKB/TrEMBL
    A0A8I6A0Z6
    Related
    ENSRNOP00000084845.1, ENSRNOT00000101645.2

  5. XM_006239395.5 → XP_006239457.1  F-box only protein 44 isoform X4

    See identical proteins and their annotated locations for XP_006239457.1

    UniProtKB/TrEMBL
    D4A6R1
    Conserved Domains (2) summary
    pfam04300
    Location:72 → 250
    FBA; F-box associated region
    pfam12937
    Location:6 → 51
    F-box-like

  6. XM_006239393.3 → XP_006239455.1  F-box only protein 44 isoform X2

    Conserved Domains (2) summary
    pfam04300
    Location:162 → 212
    FBA; F-box associated region
    pfam12937
    Location:96 → 143
    F-box-like; F-box-like

  7. XM_006239392.3 → XP_006239454.1  F-box only protein 44 isoform X1

    Related
    ENSRNOP00000059513.4, ENSRNOT00000067059.5
    Conserved Domains (2) summary
    pfam04300
    Location:162 → 340
    FBA; F-box associated region
    pfam12937
    Location:96 → 143
    F-box-like; F-box-like

  8. XM_063288304.1 → XP_063144374.1  F-box only protein 44 isoform X8

  9. XM_039110645.2 → XP_038966573.1  F-box only protein 44 isoform X7

    UniProtKB/TrEMBL
    A6IU61
    Conserved Domains (2) summary
    pfam04300
    Location:162 → 182
    FBA; F-box associated region
    pfam12937
    Location:96 → 141
    F-box-like

RNA

  1. XR_005504529.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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