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Spmip6 sperm microtubule inner protein 6 [ Rattus norvegicus (Norway rat) ]

Gene ID: 500441, updated on 4-Jan-2025

Summary

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Official Symbol
Spmip6provided by RGD
Official Full Name
sperm microtubule inner protein 6provided by RGD
Primary source
RGD:1561916
See related
EnsemblRapid:ENSRNOG00000013320 AllianceGenome:RGD:1561916
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1561916
Summary
Predicted to enable alpha-tubulin binding activity. Predicted to be involved in flagellated sperm motility. Predicted to act upstream of or within protein-containing complex assembly. Predicted to be located in several cellular components, including mitochondrion; nucleoplasm; and sperm midpiece. Predicted to be active in microtubule cytoskeleton; perinuclear region of cytoplasm; and sperm flagellum. Orthologous to human SPMIP6 (sperm microtubule inner protein 6). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Testes (RPKM 450.3) and Lung (RPKM 35.2) See more
Orthologs
human mouse all
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Genomic context

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See Spmip6 in Genome Data Viewer
Location:
5q22
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (61462070..61474832, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (56666160..56678865, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (57883713..57896449, complement)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene nudix hydrolase 2 Neighboring gene myogenesis regulating glycosidase Neighboring gene uncharacterized LOC102553821 Neighboring gene family with sequence similarity 219, member A Neighboring gene dynein, axonemal, intermediate chain 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Isolation and characterization of the spermatid-specific Smrp1 gene encoding a novel manchette protein. Matsuoka Y, et al. Mol Reprod Dev, 2008 Jun. PMID 18163442
  2. Characterization of ciliated bronchial epithelium 1, a ciliated cell-associated gene induced during mucociliary differentiation. Yoshisue H, et al. Am J Respir Cell Mol Biol, 2004 Nov. PMID 15242845
  3. Proteomic characterization of the human sperm nucleus. de Mateo S, et al. Proteomics, 2011 Jul. PMID 21630459
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables alpha-tubulin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables alpha-tubulin binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in flagellated sperm motility ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein-containing complex assembly ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in axonemal A tubule inner sheath ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in manchette IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in manchette ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
is_active_in perinuclear region of cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in sperm flagellum ISO
Inferred from Sequence Orthology
more info
  
located_in sperm midpiece ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
sperm microtubule inner protein 6
Names
spermatid-specific manchette-related protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001419511.1 → NP_001406440.1  sperm microtubule inner protein 6 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005

  2. NM_001419512.1 → NP_001406441.1  sperm microtubule inner protein 6 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/TrEMBL
    A6IIV4

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    61462070..61474832 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_575803.9 → XP_575803.4  sperm microtubule inner protein 6 isoform X1

    See identical proteins and their annotated locations for XP_575803.4

    UniProtKB/TrEMBL
    D4A9U1
    Related
    ENSRNOP00000017903.7, ENSRNOT00000017903.10
    Conserved Domains (1) summary
    pfam15181
    Location:1 → 256
    SMRP1; Spermatid-specific manchette-related protein 1

  2. XM_063288217.1 → XP_063144287.1  sperm microtubule inner protein 6 isoform X2

  3. XM_017593717.3 → XP_017449206.3  sperm microtubule inner protein 6 isoform X3

  4. XM_006238116.5 → XP_006238178.1  sperm microtubule inner protein 6 isoform X5

    See identical proteins and their annotated locations for XP_006238178.1

    Conserved Domains (1) summary
    pfam15181
    Location:1 → 122
    SMRP1; Spermatid-specific manchette-related protein 1

  5. XM_063288218.1 → XP_063144288.1  sperm microtubule inner protein 6 isoform X4

    UniProtKB/TrEMBL
    A6IIV5

  6. XM_039110968.2 → XP_038966896.1  sperm microtubule inner protein 6 isoform X4

    UniProtKB/TrEMBL
    A6IIV5
    Conserved Domains (1) summary
    pfam15181
    Location:1 → 157
    SMRP1; Spermatid-specific manchette-related protein 1
Nucleotide Protein Strain
Heading Accession and Version

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