Cidec cell death-inducing DFFA-like effector c [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cidecprovided by RGD
Official Full Name: cell death-inducing DFFA-like effector cprovided by RGD
Primary source: RGD:1562113
See related: EnsemblRapid:ENSRNOG00000009153 AllianceGenome:RGD:1562113
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable lipid transfer activity; molecular condensate scaffold activity; and phospholipid binding activity. Predicted to be involved in several processes, including lipid droplet fusion; lipid storage; and negative regulation of lipid metabolic process. Predicted to act upstream of or within apoptotic process. Predicted to be located in cytosol. Predicted to be active in lipid droplet. Human ortholog(s) of this gene implicated in familial partial lipodystrophy type 5. Orthologous to human CIDEC (cell death inducing DFFA like effector c). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Thymus (RPKM 400.3), Adrenal (RPKM 349.7) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q42

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (148124924..148137806, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (146569288..146582173, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (145377482..145390497, complement)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CIDEC silencing attenuates diabetic nephropathy via inhibiting apoptosis and promoting autophagy.
Title: CIDEC silencing attenuates diabetic nephropathy via inhibiting apoptosis and promoting autophagy.
FSP27 is associated with rat lipid metabolism and its expression varies with energy and nutrient supply. It can inhibit excessive hydrolysis and fat accumulation by regulating HSL and ATGL expression and by mediating LDs formation.
Title: Bariatric Surgery in Rats Upregulates FSP27 Expression in Fat Tissue to Affect Fat Hydrolysis and Metabolism.
Study shows that cell death-inducing DFF45-like effector C gene silencing alleviates pulmonary vascular remodeling in a type 2 diabetic rat model. The CIDEC/5' monophosphate-activated protein kinase signaling pathway could be a potential therapeutic candidate against pulmonary vascular diseases in type 2 diabetes patients.
Title: Cell death-inducing DFF45-like effector C gene silencing alleviates pulmonary vascular remodeling in a type 2 diabetic rat model.
esveratrol can correct fat formation and storage imbalance status by up-regulating FSP27 and down-regulating PPAR-gamma expression level, ameliorating insulin sensitivity.
Title: The role of expression imbalance between adipose synthesis and storage mediated by PPAR-γ/FSP27 in the formation of insulin resistance in catch up growth.
Long-term intermittent fasting, in contrast to other dietary manipulations, significantly up-regulated Fsp27 gene expression in white adipose tissue.
Title: Intermittent fasting up-regulates Fsp27/Cidec gene expression in white adipose tissue.
From these findings, it can be concluded that Fsp27 expression suppressed HSC activation in vitro and liver fibrogenesis in vivo
Title: Inhibition of hepatic stellate cell activation and liver fibrosis by fat-specific protein 27.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables lipid transfer activity	ISO Inferred from Sequence Orthology more info
enables lipid transfer activity	ISS Inferred from Sequence or Structural Similarity more info
enables molecular condensate scaffold activity	ISO Inferred from Sequence Orthology more info
enables molecular condensate scaffold activity	ISS Inferred from Sequence or Structural Similarity more info
enables phosphatidic acid binding	ISO Inferred from Sequence Orthology more info
enables phosphatidic acid binding	ISS Inferred from Sequence or Structural Similarity more info
enables phosphatidylinositol binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylserine binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in execution phase of apoptosis	IEA Inferred from Electronic Annotation more info
involved_in execution phase of apoptosis	ISO Inferred from Sequence Orthology more info
involved_in intermembrane lipid transfer	IEA Inferred from Electronic Annotation more info
involved_in lipid droplet fusion	IEA Inferred from Electronic Annotation more info
involved_in lipid droplet fusion	ISO Inferred from Sequence Orthology more info
involved_in lipid droplet fusion	ISS Inferred from Sequence or Structural Similarity more info
involved_in lipid droplet organization	ISO Inferred from Sequence Orthology more info
involved_in lipid storage	IEA Inferred from Electronic Annotation more info
involved_in lipid storage	ISO Inferred from Sequence Orthology more info
involved_in lipid storage	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of lipid catabolic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of lipid catabolic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of lipid catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of triglyceride metabolic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of triglyceride metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in lipid droplet	IEA Inferred from Electronic Annotation more info
is_active_in lipid droplet	ISO Inferred from Sequence Orthology more info
is_active_in lipid droplet	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: lipid transferase CIDEC

Names: cell death activator CIDE-3; cell death-inducing DFFA-like effector protein C; fat-specific protein FSP27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001024333.2 → NP_001019504.2 lipid transferase CIDEC isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

BC083860, BQ194098

UniProtKB/TrEMBL

A0A0G2K551, A0A8I6A975

Related

ENSRNOP00000073293.1, ENSRNOT00000091965.3

Conserved Domains (1) summary

cl02541
Location:51 → 130

CIDE_N; CIDE_N domain, found at the N-terminus of the CIDE (cell death-inducing DFF45-like effector) proteins, as well as CAD nuclease (caspase-activated DNase/DNA fragmentation factor, DFF40) and its inhibitor, ICAD(DFF45). These proteins are associated with ...
NM_001244797.1 → NP_001231726.1 lipid transferase CIDEC isoform 2

See identical proteins and their annotated locations for NP_001231726.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' exon, which results in a downstream AUG start codon, compared to variant 1. The resulting isoform (2) is shorter at the N-terminus than isoform 1.

Source sequence(s)

BC083860, BQ194098, FM043477, FM103335

UniProtKB/Swiss-Prot

Q5XI33

UniProtKB/TrEMBL

A0A8I6A975

Related

ENSRNOP00000012136.4, ENSRNOT00000012136.8

Conserved Domains (1) summary

cl02541
Location:41 → 120

CIDE_N; CIDE_N domain, found at the N-terminus of the CIDE (cell death-inducing DFF45-like effector) proteins, as well as CAD nuclease (caspase-activated DNase/DNA fragmentation factor, DFF40) and its inhibitor, ICAD(DFF45). These proteins are associated with ...
NM_001244798.1 → NP_001231727.1 lipid transferase CIDEC isoform 2

See identical proteins and their annotated locations for NP_001231727.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' exon, which results in a downstream AUG start codon, compared to variant 1. The resulting isoform (2) is shorter at the N-terminus than isoform 1.

Source sequence(s)

BC083860, BQ194098, FM103335

UniProtKB/Swiss-Prot

Q5XI33

UniProtKB/TrEMBL

A0A8I6A975

Related

ENSRNOP00000090307.2, ENSRNOT00000118684.2

Conserved Domains (1) summary

cl02541
Location:41 → 120

CIDE_N; CIDE_N domain, found at the N-terminus of the CIDE (cell death-inducing DFF45-like effector) proteins, as well as CAD nuclease (caspase-activated DNase/DNA fragmentation factor, DFF40) and its inhibitor, ICAD(DFF45). These proteins are associated with ...