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Magi1 membrane associated guanylate kinase, WW and PDZ domain containing 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 500261, updated on 4-Jan-2025

Summary

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Official Symbol
Magi1provided by RGD
Official Full Name
membrane associated guanylate kinase, WW and PDZ domain containing 1provided by RGD
Primary source
RGD:1586025
See related
EnsemblRapid:ENSRNOG00000022060 AllianceGenome:RGD:1586025
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
BAP-1; Baiap1; MAGI-1
Summary
Predicted to enable alpha-actinin binding activity. Predicted to be involved in endothelial cell morphogenesis; positive regulation of cell-cell adhesion; and signal transduction. Predicted to be located in several cellular components, including adherens junction; nuclear lumen; and plasma membrane. Predicted to be active in cell-cell junction and cytoplasm. Orthologous to human MAGI1 (membrane associated guanylate kinase, WW and PDZ domain containing 1). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Brain (RPKM 115.8), Lung (RPKM 114.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Magi1 in Genome Data Viewer
Location:
4q34
Exon count:
32
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (127762590..128368228, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (126205663..126811354, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (125684816..126300013, complement)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA17 Neighboring gene ribosomal protein lateral stalk subunit P0, pseudogene 15 Neighboring gene uncharacterized LOC134486617 Neighboring gene transfer RNA threonine (anticodon AGU) 30 Neighboring gene small nucleolar RNA SNORA44 Neighboring gene GABA type A receptor-associated protein, pseudogene 3 Neighboring gene dynein light chain LC8-type 1 like 1 Neighboring gene uncharacterized LOC120102497 Neighboring gene elongin B, pseduogene 12 Neighboring gene single stranded DNA binding protein 1, pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Biochemical and morphological characterization of MAGI-1 in neuronal tissue. Ito H, et al. J Neurosci Res, 2012 Sep. PMID 22605569
  2. MiR-205-5p-Mediated MAGI1 Inhibition Attenuates the Injury Induced by Diabetic Nephropathy. Xiang Y, et al. Pharmacology, 2024. PMID 38325349
  3. Regulation of glutamate transporter GLT-1 by MAGI-1. Zou S, et al. J Neurochem, 2011 Jun. PMID 21426345
  4. MAGI-1a functions as a scaffolding protein for the distal renal tubular basolateral K+ channels. Tanemoto M, et al. J Biol Chem, 2008 May 2. PMID 18303016
  5. Magi-1 scaffolds Na(V)1.8 and Slack K(Na) channels in dorsal root ganglion neurons regulating excitability and pain. Pryce KD, et al. FASEB J, 2019 Jun. PMID 30860870, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MiR-205-5p-Mediated MAGI1 Inhibition Attenuates the Injury Induced by Diabetic Nephropathy.
    Title: MiR-205-5p-Mediated MAGI1 Inhibition Attenuates the Injury Induced by Diabetic Nephropathy.
  2. Dorsal root ganglion (DRG)-specific knockdown of Magi-1 attenuated thermal nociception and acute inflammatory pain and NaV1.8 protein expression. Magi-1 bound to Slack potassium channels, macrocomplexing with NaV1.8 channels.Magi-1 is an essential scaffold for ion transport in DRG neurons and a central player in pain.Magi-1 is expressed in small- and medium-sized DRG neurons, their axonal tracts, and nodes of Ranvier.
    Title: Magi-1 scaffolds Na(V)1.8 and Slack K(Na) channels in dorsal root ganglion neurons regulating excitability and pain.
  3. MAGI-1 was expressed in Purkinje cells, in hypocampal neurons in CA1 region, in the glomerulus region of olfactory bulb, and at the dorsal root entry zone in embryonic rat spinal cord
    Title: Biochemical and morphological characterization of MAGI-1 in neuronal tissue.
  4. These results demonstrate that the phosphorylation-dependent scaffolding of the basolateral K(+) channels by MAGI-1a-long participates in the renal regulation of the fluid and electrolyte homeostasis.
    Title: MAGI-1a functions as a scaffolding protein for the distal renal tubular basolateral K+ channels.
  5. These data suggest that MAGI-1 regulates surface expression of GLT-1 and the level of glutamate in the hippocampus
    Title: Regulation of glutamate transporter GLT-1 by MAGI-1.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables alpha-actinin binding IEA
Inferred from Electronic Annotation
more info
  
enables alpha-actinin binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in endothelial cell morphogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in endothelial cell morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in endothelial cell morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of cell-cell adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
  
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in adherens junction IEA
Inferred from Electronic Annotation
more info
  
located_in adherens junction ISO
Inferred from Sequence Orthology
more info
  
located_in adherens junction ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in bicellular tight junction IEA
Inferred from Electronic Annotation
more info
  
located_in cell junction ISO
Inferred from Sequence Orthology
more info
  
located_in cell periphery ISO
Inferred from Sequence Orthology
more info
  
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cell projection ISO
Inferred from Sequence Orthology
more info
  
is_active_in cell-cell junction IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cell-cell junction ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1
Names
BAI1-associated protein 1
membrane-associated guanylate kinase inverted 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001030045.2 → NP_001025216.2  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/Swiss-Prot
    Q4L1J4, Q4L1J5

  2. NM_001401825.1 → NP_001388754.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/TrEMBL
    A0A0G2JZE4
    Related
    ENSRNOP00000100639.1, ENSRNOT00000133320.1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    127762590..128368228 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006236927.5 → XP_006236989.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X2

    UniProtKB/TrEMBL
    A0A0G2JZE4
    Related
    ENSRNOP00000065881.4, ENSRNOT00000071315.5
    Conserved Domains (6) summary
    smart00228
    Location:1151 → 1233
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00201
    Location:303 → 332
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    cd00992
    Location:995 → 1090
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00397
    Location:361 → 390
    WW; WW domain
    pfam16666
    Location:721 → 804
    MAGI_u5; Unstructured region on MAGI
    cl17190
    Location:122 → 293
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

  2. XM_039108183.2 → XP_038964111.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X22

    UniProtKB/TrEMBL
    A0A8I6ABL7
    Related
    ENSRNOP00000033083.8, ENSRNOT00000037848.8
    Conserved Domains (6) summary
    smart00456
    Location:361 → 392
    WW; Domain with 2 conserved Trp (W) residues
    smart00228
    Location:1151 → 1233
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00201
    Location:303 → 332
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    cd00992
    Location:995 → 1090
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam16666
    Location:723 → 805
    MAGI_u5; Unstructured region on MAGI
    cl17190
    Location:122 → 293
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

  3. XM_039108192.2 → XP_038964120.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X40

    UniProtKB/TrEMBL
    A0A8I5Y118
    Conserved Domains (6) summary
    smart00456
    Location:349 → 380
    WW; Domain with 2 conserved Trp (W) residues
    smart00228
    Location:1042 → 1124
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:805 → 880
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00397
    Location:302 → 331
    WW; WW domain
    pfam16666
    Location:711 → 798
    MAGI_u5; Unstructured region on MAGI
    cl17190
    Location:122 → 293
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

  4. XM_063286549.1 → XP_063142619.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X25

    UniProtKB/TrEMBL
    A0A8I6ABL7

  5. XM_039108195.2 → XP_038964123.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X44

    UniProtKB/TrEMBL
    A0A8I6ABL7
    Conserved Domains (6) summary
    smart00456
    Location:349 → 380
    WW; Domain with 2 conserved Trp (W) residues
    smart00228
    Location:1110 → 1192
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00201
    Location:303 → 332
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    cd00992
    Location:955 → 1049
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam16666
    Location:711 → 799
    MAGI_u5; Unstructured region on MAGI
    cl17190
    Location:122 → 293
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

  6. XM_039108194.2 → XP_038964122.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X43

    UniProtKB/TrEMBL
    A0A8I6ABL7
    Conserved Domains (6) summary
    smart00456
    Location:349 → 380
    WW; Domain with 2 conserved Trp (W) residues
    smart00228
    Location:1138 → 1220
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00201
    Location:303 → 332
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    cd00992
    Location:983 → 1077
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam16666
    Location:711 → 793
    MAGI_u5; Unstructured region on MAGI
    cl17190
    Location:122 → 293
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

  7. XM_063286563.1 → XP_063142633.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X38

    UniProtKB/TrEMBL
    A0A8I6ABL7

  8. XM_039108184.2 → XP_038964112.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X24

    UniProtKB/TrEMBL
    A0A8I6ABL7
    Conserved Domains (6) summary
    smart00456
    Location:361 → 392
    WW; Domain with 2 conserved Trp (W) residues
    smart00228
    Location:1150 → 1232
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00201
    Location:303 → 332
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    cd00992
    Location:995 → 1089
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam16666
    Location:723 → 805
    MAGI_u5; Unstructured region on MAGI
    cl17190
    Location:122 → 293
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

  9. XM_063286565.1 → XP_063142635.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X39

    UniProtKB/TrEMBL
    A0A8I5Y118

  10. XM_063286557.1 → XP_063142627.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X31

    UniProtKB/TrEMBL
    A0A8I6ABL7

  11. XM_063286562.1 → XP_063142632.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X37

    UniProtKB/TrEMBL
    A0A8I6ABL7

  12. XM_063286550.1 → XP_063142620.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X26

    UniProtKB/TrEMBL
    A0A8I6ABL7

  13. XM_063286548.1 → XP_063142618.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X23

    UniProtKB/TrEMBL
    A0A8I6ABL7

  14. XM_039108182.2 → XP_038964110.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X21

    UniProtKB/TrEMBL
    A0A8I6ABL7
    Conserved Domains (6) summary
    smart00456
    Location:362 → 393
    WW; Domain with 2 conserved Trp (W) residues
    smart00228
    Location:1152 → 1234
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00201
    Location:303 → 332
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    cd00992
    Location:996 → 1091
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam16666
    Location:724 → 806
    MAGI_u5; Unstructured region on MAGI
    cl17190
    Location:122 → 293
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

  15. XM_063286541.1 → XP_063142611.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X6

    UniProtKB/TrEMBL
    A0A0G2JZE4

  16. XM_039108176.2 → XP_038964104.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X5

    UniProtKB/TrEMBL
    A0A0G2JZE4
    Conserved Domains (6) summary
    smart00456
    Location:361 → 392
    WW; Domain with 2 conserved Trp (W) residues
    smart00228
    Location:1150 → 1232
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:994 → 1089
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00397
    Location:302 → 331
    WW; WW domain
    pfam16666
    Location:723 → 804
    MAGI_u5; Unstructured region on MAGI
    cl17190
    Location:122 → 293
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

  17. XM_063286551.1 → XP_063142621.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X27

    UniProtKB/TrEMBL
    A0A8I6ABL7

  18. XM_039108175.2 → XP_038964103.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X4

    UniProtKB/TrEMBL
    A0A0G2JZE4
    Conserved Domains (6) summary
    smart00456
    Location:362 → 393
    WW; Domain with 2 conserved Trp (W) residues
    smart00228
    Location:1151 → 1233
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:995 → 1090
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00397
    Location:302 → 331
    WW; WW domain
    pfam16666
    Location:724 → 805
    MAGI_u5; Unstructured region on MAGI
    cl17190
    Location:122 → 293
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

  19. XM_039108193.2 → XP_038964121.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X16

    UniProtKB/TrEMBL
    A0A0G2JZE4
    Conserved Domains (6) summary
    smart00456
    Location:349 → 380
    WW; Domain with 2 conserved Trp (W) residues
    smart00228
    Location:1110 → 1192
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:955 → 1049
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00397
    Location:302 → 331
    WW; WW domain
    pfam16666
    Location:711 → 799
    MAGI_u5; Unstructured region on MAGI
    cl17190
    Location:122 → 293
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

  20. XM_063286543.1 → XP_063142613.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X14

    UniProtKB/TrEMBL
    A0A0G2JZE4

  21. XM_006236929.5 → XP_006236991.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X9

    UniProtKB/TrEMBL
    A0A0G2JZE4
    Conserved Domains (6) summary
    smart00228
    Location:1138 → 1220
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00201
    Location:303 → 332
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    cd00992
    Location:983 → 1077
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00397
    Location:349 → 378
    WW; WW domain
    pfam16666
    Location:709 → 792
    MAGI_u5; Unstructured region on MAGI
    cl17190
    Location:122 → 293
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

  22. XM_039108177.2 → XP_038964105.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X8

    UniProtKB/TrEMBL
    A0A0G2JZE4
    Conserved Domains (6) summary
    smart00456
    Location:349 → 380
    WW; Domain with 2 conserved Trp (W) residues
    smart00228
    Location:1139 → 1221
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:983 → 1078
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00397
    Location:302 → 331
    WW; WW domain
    pfam16666
    Location:711 → 793
    MAGI_u5; Unstructured region on MAGI
    cl17190
    Location:122 → 293
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

  23. XM_063286547.1 → XP_063142617.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X20

    UniProtKB/TrEMBL
    A0A0G2JZE4

  24. XM_063286545.1 → XP_063142615.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X17

    UniProtKB/TrEMBL
    A0A0G2JZE4

  25. XM_063286544.1 → XP_063142614.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X15

    UniProtKB/TrEMBL
    A0A0G2JZE4

  26. XM_008763133.4 → XP_008761355.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X12

    UniProtKB/TrEMBL
    A0A0G2JZE4
    Conserved Domains (6) summary
    smart00228
    Location:1122 → 1204
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00201
    Location:303 → 332
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    cd00992
    Location:967 → 1061
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00397
    Location:361 → 390
    WW; WW domain
    pfam16666
    Location:721 → 804
    MAGI_u5; Unstructured region on MAGI
    cl17190
    Location:122 → 293
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

  27. XM_039108179.2 → XP_038964107.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X11

    UniProtKB/TrEMBL
    A0A0G2JZE4, F1M7H7
    Related
    ENSRNOP00000099821.1, ENSRNOT00000164096.1
    Conserved Domains (6) summary
    smart00456
    Location:361 → 392
    WW; Domain with 2 conserved Trp (W) residues
    smart00228
    Location:1123 → 1205
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:967 → 1062
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00397
    Location:302 → 331
    WW; WW domain
    pfam16666
    Location:723 → 811
    MAGI_u5; Unstructured region on MAGI
    cl17190
    Location:122 → 293
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

  28. XM_063286546.1 → XP_063142616.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X19

    UniProtKB/TrEMBL
    A0A0G2JZE4

  29. XM_063286542.1 → XP_063142612.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X13

    UniProtKB/TrEMBL
    A0A0G2JZE4

  30. XM_039108178.2 → XP_038964106.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X10

    UniProtKB/TrEMBL
    A0A0G2JZE4
    Conserved Domains (6) summary
    smart00456
    Location:362 → 393
    WW; Domain with 2 conserved Trp (W) residues
    smart00228
    Location:1124 → 1206
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:968 → 1063
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00397
    Location:302 → 331
    WW; WW domain
    pfam16666
    Location:724 → 812
    MAGI_u5; Unstructured region on MAGI
    cl17190
    Location:122 → 293
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

  31. XM_039108181.2 → XP_038964109.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X18

    UniProtKB/TrEMBL
    A0A0G2JZE4
    Conserved Domains (6) summary
    smart00456
    Location:362 → 393
    WW; Domain with 2 conserved Trp (W) residues
    smart00228
    Location:1084 → 1166
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:847 → 922
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00397
    Location:302 → 331
    WW; WW domain
    pfam16666
    Location:724 → 806
    MAGI_u5; Unstructured region on MAGI
    cl17190
    Location:122 → 293
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

  32. XM_017592832.3 → XP_017448321.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X7

    UniProtKB/TrEMBL
    A0A0G2JZE4

  33. XM_039108174.2 → XP_038964102.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X3

    UniProtKB/TrEMBL
    A0A0G2JZE4
    Conserved Domains (6) summary
    smart00456
    Location:362 → 393
    WW; Domain with 2 conserved Trp (W) residues
    smart00228
    Location:1151 → 1233
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:996 → 1090
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00397
    Location:302 → 331
    WW; WW domain
    pfam16666
    Location:724 → 806
    MAGI_u5; Unstructured region on MAGI
    cl17190
    Location:122 → 293
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

  34. XM_039108173.2 → XP_038964101.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JZE4
    Conserved Domains (6) summary
    smart00456
    Location:362 → 393
    WW; Domain with 2 conserved Trp (W) residues
    smart00228
    Location:1152 → 1234
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:996 → 1091
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00397
    Location:302 → 331
    WW; WW domain
    pfam16666
    Location:724 → 806
    MAGI_u5; Unstructured region on MAGI
    cl17190
    Location:122 → 293
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

  35. XM_063286554.1 → XP_063142624.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X28

    UniProtKB/TrEMBL
    A0A0G2JZE4

  36. XM_063286553.1 → XP_063142623.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X28

    UniProtKB/TrEMBL
    A0A0G2JZE4

  37. XM_063286552.1 → XP_063142622.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X28

    UniProtKB/TrEMBL
    A0A0G2JZE4

  38. XM_063286567.1 → XP_063142637.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X42

    UniProtKB/TrEMBL
    M0R8T1

  39. XM_063286559.1 → XP_063142629.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X33

    UniProtKB/TrEMBL
    A0A0G2JZE4

  40. XM_063286560.1 → XP_063142630.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X34

    UniProtKB/TrEMBL
    A0A0G2JZE4

  41. XM_039108188.2 → XP_038964116.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X28

    UniProtKB/TrEMBL
    A0A0G2JZE4
    Conserved Domains (7) summary
    smart00456
    Location:135 → 166
    WW; Domain with 2 conserved Trp (W) residues
    smart00228
    Location:925 → 1007
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    PRK12678
    Location:1044 → 1253
    PRK12678; transcription termination factor Rho; Provisional
    cd00992
    Location:769 → 864
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00397
    Location:75 → 104
    WW; WW domain
    pfam16663
    Location:1 → 33
    MAGI_u1; Unstructured region on MAGI
    pfam16666
    Location:497 → 579
    MAGI_u5; Unstructured region on MAGI

  42. XM_063286566.1 → XP_063142636.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X41

    UniProtKB/TrEMBL
    M0R8T1

  43. XM_063286555.1 → XP_063142625.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X29

    UniProtKB/TrEMBL
    A0A0G2JZE4

  44. XM_039108191.2 → XP_038964119.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X28

    UniProtKB/TrEMBL
    A0A0G2JZE4
    Conserved Domains (7) summary
    smart00456
    Location:135 → 166
    WW; Domain with 2 conserved Trp (W) residues
    smart00228
    Location:925 → 1007
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    PRK12678
    Location:1044 → 1253
    PRK12678; transcription termination factor Rho; Provisional
    cd00992
    Location:769 → 864
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00397
    Location:75 → 104
    WW; WW domain
    pfam16663
    Location:1 → 33
    MAGI_u1; Unstructured region on MAGI
    pfam16666
    Location:497 → 579
    MAGI_u5; Unstructured region on MAGI

  45. XM_063286556.1 → XP_063142626.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X30

    UniProtKB/TrEMBL
    A0A0G2JZE4

  46. XM_039108185.2 → XP_038964113.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X28

    UniProtKB/TrEMBL
    A0A0G2JZE4
    Conserved Domains (7) summary
    smart00456
    Location:135 → 166
    WW; Domain with 2 conserved Trp (W) residues
    smart00228
    Location:925 → 1007
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    PRK12678
    Location:1044 → 1253
    PRK12678; transcription termination factor Rho; Provisional
    cd00992
    Location:769 → 864
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00397
    Location:75 → 104
    WW; WW domain
    pfam16663
    Location:1 → 33
    MAGI_u1; Unstructured region on MAGI
    pfam16666
    Location:497 → 579
    MAGI_u5; Unstructured region on MAGI

  47. XM_063286561.1 → XP_063142631.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X36

    UniProtKB/Swiss-Prot
    Q4L1J4, Q4L1J5

  48. XM_063286558.1 → XP_063142628.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X32

    UniProtKB/Swiss-Prot
    Q4L1J4, Q4L1J5

  49. XM_039108189.2 → XP_038964117.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X35

    UniProtKB/Swiss-Prot
    Q4L1J4, Q4L1J5
    Conserved Domains (6) summary
    smart00456
    Location:361 → 392
    WW; Domain with 2 conserved Trp (W) residues
    smart00228
    Location:1123 → 1205
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:967 → 1062
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00397
    Location:302 → 331
    WW; WW domain
    pfam16666
    Location:723 → 811
    MAGI_u5; Unstructured region on MAGI
    cl17190
    Location:122 → 293
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q4L1J4.1 GenPept UniProtKB/Swiss-Prot:Q4L1J4

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