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ORC5 origin recognition complex subunit 5 [ Homo sapiens (human) ]

Gene ID: 5001, updated on 27-Nov-2024

Summary

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Official Symbol
ORC5provided by HGNC
Official Full Name
origin recognition complex subunit 5provided by HGNC
Primary source
HGNC:HGNC:8491
See related
Ensembl:ENSG00000164815 MIM:602331; AllianceGenome:HGNC:8491
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ORC5L; ORC5P; ORC5T; PPP1R117
Summary
The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Oct 2010]
Expression
Ubiquitous expression in testis (RPKM 5.7), prostate (RPKM 4.4) and 25 other tissues See more
Orthologs
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Genomic context

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See ORC5 in Genome Data Viewer
Location:
7q22.1-q22.2
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (104126341..104208013, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (105440576..105522271, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (103766788..103848461, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene SLC26A5 antisense RNA 1 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr7:103130126-103131325 Neighboring gene uncharacterized LOC105375435 Neighboring gene Sharpr-MPRA regulatory region 15155 Neighboring gene RN7SK pseudogene 86 Neighboring gene reelin Neighboring gene MED14-independent group 3 enhancer GRCh37_chr7:103301048-103302247 Neighboring gene Sharpr-MPRA regulatory region 11588 Neighboring gene MPRA-validated peak6667 silencer Neighboring gene Sharpr-MPRA regulatory region 1232 Neighboring gene CRISPRi-validated cis-regulatory element chr7.3907 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:103691916-103692125 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:103765716-103765879 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26443 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26444 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26445 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr7:103904410-103905609 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr7:103916337-103917536 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:104001319-104001836 Neighboring gene LHFPL tetraspan subfamily member 3 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr7:104169841-104171040 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr7:104190573-104191772 Neighboring gene eukaryotic translation initiation factor 4B pseudogene 6 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:104412644-104413408 Neighboring gene LHFPL3 antisense RNA 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Mutation analysis of the origin recognition complex subunit 5 (ORC5L) gene in adult patients with myeloid leukemias exhibiting deletions of chromosome band 7q22. Fröhling S, et al. Hum Genet, 2001 Apr. PMID 11379876
  2. Isolation of human and fission yeast homologues of the budding yeast origin recognition complex subunit ORC5: human homologue (ORC5L) maps to 7q22. Ishiai M, et al. Genomics, 1997 Dec 1. PMID 9417919
  3. Orc5 induces large-scale chromatin decondensation in a GCN5-dependent manner. Giri S, et al. J Cell Sci, 2016 Jan 15. PMID 26644179, Free PMC Article
  4. A human cancer cell line initiates DNA replication normally in the absence of ORC5 and ORC2 proteins. Shibata E, et al. J Biol Chem, 2020 Dec 11. PMID 32989049, Free PMC Article
  5. ORC5L, a new member of the human origin recognition complex, is deleted in uterine leiomyomas and malignant myeloid diseases. Quintana DG, et al. J Biol Chem, 1998 Oct 16. PMID 9765232

See all (78) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A human cancer cell line initiates DNA replication normally in the absence of ORC5 and ORC2 proteins.
    Title: A human cancer cell line initiates DNA replication normally in the absence of ORC5 and ORC2 proteins.
  2. Orc5 associates with the H3 histone acetyl transferase GCN5 (also known as KAT2A), and this association enhances the chromatin-opening function of Orc5.
    Title: Orc5 induces large-scale chromatin decondensation in a GCN5-dependent manner.
  3. Observational study of gene-disease association. (HuGE Navigator)
    Title: An approach based on a genome-wide association study reveals candidate loci for narcolepsy.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA replication origin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleotide binding TAS
Traceable Author Statement
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA replication NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in DNA replication initiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA replication initiation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of DNA replication IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in chromatin IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chromosome, telomeric region HDA PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
  
part_of nuclear origin of replication recognition complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of nuclear origin of replication recognition complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of nuclear origin of replication recognition complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of nuclear origin of replication recognition complex NAS
Non-traceable Author Statement
more info
 PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
located_in nucleus NAS
Non-traceable Author Statement
more info
 PubMed 
part_of origin recognition complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
origin recognition complex subunit 5
Names
protein phosphatase 1, regulatory subunit 117

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029899.2 RefSeqGene

    Range
    5000..86672
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_002553.4 → NP_002544.1  origin recognition complex subunit 5 isoform 1

    See identical proteins and their annotated locations for NP_002544.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC007393, AK223361, BC023652
    Consensus CDS
    CCDS5734.1
    UniProtKB/Swiss-Prot
    A4D0P8, O43913, O60590, O95268
    UniProtKB/TrEMBL
    A4D0P7, Q53FC8
    Related
    ENSP00000297431.4, ENST00000297431.9
    Conserved Domains (2) summary
    pfam13191
    Location:8 → 155
    AAA_16; AAA ATPase domain
    pfam14630
    Location:177 → 431
    ORC5_C; Origin recognition complex (ORC) subunit 5 C-terminus

  2. NM_181747.4 → NP_859531.1  origin recognition complex subunit 5 isoform 2

    See identical proteins and their annotated locations for NP_859531.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks multiple 3' exon, but has an alternate 3' segment, as compared to variant 1. The resulting isoform (2) is much shorter and has a distinct C-terminus, as compared to isoform 1.
    Source sequence(s)
    AC007393, AF081459, AK223361
    Consensus CDS
    CCDS47681.1
    UniProtKB/Swiss-Prot
    O43913
    UniProtKB/TrEMBL
    Q53FC8
    Related
    ENSP00000395747.2, ENST00000447452.6
    Conserved Domains (2) summary
    pfam13191
    Location:8 → 155
    AAA_16; AAA ATPase domain
    pfam14630
    Location:177 → 290
    ORC5_C; Origin recognition complex (ORC) subunit 5 C-terminus

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    104126341..104208013 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047420431.1 → XP_047276387.1  origin recognition complex subunit 5 isoform X2

  2. XM_011516273.4 → XP_011514575.1  origin recognition complex subunit 5 isoform X1

    Conserved Domains (3) summary
    COG1474
    Location:11 → 191
    CDC6; Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair]
    pfam13191
    Location:8 → 155
    AAA_16; AAA ATPase domain
    pfam14630
    Location:177 → 228
    ORC5_C; Origin recognition complex (ORC) subunit 5 C-terminus

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    105440576..105522271 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054358314.1 → XP_054214289.1  origin recognition complex subunit 5 isoform X2

  2. XM_054358313.1 → XP_054214288.1  origin recognition complex subunit 5 isoform X1

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001197292.1: Suppressed sequence

    Description
    NM_001197292.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O43913.1 GenPept UniProtKB/Swiss-Prot:O43913

Gene LinkOut

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