Tes testin LIM domain protein [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tesprovided by RGD
Official Full Name: testin LIM domain proteinprovided by RGD
Primary source: RGD:1566346
See related: EnsemblRapid:ENSRNOG00000051952 AllianceGenome:RGD:1566346
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable zinc ion binding activity. Predicted to be involved in negative regulation of cell population proliferation. Predicted to be located in cytosol; focal adhesion; and plasma membrane. Predicted to be part of protein-containing complex. Orthologous to human TES (testin LIM domain protein). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Adrenal (RPKM 777.8), Uterus (RPKM 251.4) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q22

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (46331257..46369782)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (45365304..45403829)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (44321883..44360407)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Molecular recognition of the Tes LIM2-3 domains by the actin-related protein Arp7A.
Title: Molecular recognition of the Tes LIM2-3 domains by the actin-related protein Arp7A.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI236772 (e-PCR)
- UniSTS:250631

RH139200 (e-PCR)
- UniSTS:221286

Tes (e-PCR), detects polymorphism
- UniSTS:508036

RH142926 (e-PCR)
- UniSTS:232173

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cell junction	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in focal adhesion	IEA Inferred from Electronic Annotation more info
located_in focal adhesion	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: testin

Names: testis derived transcript

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001039344.2 → NP_001034433.1 testin

See identical proteins and their annotated locations for NP_001034433.1

Status: PROVISIONAL

Source sequence(s)

BC129069

UniProtKB/Swiss-Prot

Q2LAP6

UniProtKB/TrEMBL

A0A8I6AV73, A6IE14

Related

ENSRNOP00000070338.1, ENSRNOT00000091095.3

Conserved Domains (4) summary

cd09413
Location:234 → 291

LIM1_Testin; The first LIM domain of Testin

cd09416
Location:297 → 352

LIM2_Testin; The second LIM domain of Testin

cd09419
Location:359 → 417

LIM3_Testin; The third LIM domain of Testin

cd09829
Location:109 → 196

PET_testin; The PET domain of Testin