U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

COX7A Cytochrome c oxidase subunit 7A [ Drosophila melanogaster (fruit fly) ]

Gene ID: 50002, updated on 4-Jan-2025

Summary

Go to the top of the page Help
Official Symbol
COX7Aprovided by FlyBase
Official Full Name
Cytochrome c oxidase subunit 7Aprovided by FlyBase
Primary source
FLYBASE:FBgn0040529
Locus tag
Dmel_CG9603
See related
AllianceGenome:FB:FBgn0040529
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG9603; COX-7A; cox7a; Cox7a; COX7a; COX7A1; COXJ; COXK; Dmel\CG9603; Q9VHS2; VIIa
Summary
Predicted to be involved in mitochondrial respirasome assembly and regulation of oxidative phosphorylation. Located in mitochondrial inner membrane. Part of respiratory chain complex IV. Is expressed in adult head and adult heart. Used to study cytochrome-c oxidase deficiency disease and epilepsy. Orthologous to several human genes including COX7A1 (cytochrome c oxidase subunit 7A1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See COX7A in Genome Data Viewer
Location:
84F13-84F13; 3-48 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (8339944..8341043, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (4165666..4166765, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Pox meso Neighboring gene Odorant receptor 85a Neighboring gene uncharacterized protein Neighboring gene ADP ribosylation factor-like 2 Neighboring gene Polynucleotide kinase 3'-phosphatase Neighboring gene Cytochrome c oxidase subunit 7A-like

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Diiron centre mutations in Ciona intestinalis alternative oxidase abolish enzymatic activity and prevent rescue of cytochrome oxidase deficiency in flies. Andjelković A, et al. Sci Rep, 2015 Dec 17. PMID 26672986, Free PMC Article
  2. Effects on Dopaminergic Neurons Are Secondary in COX-Deficient Locomotor Dysfunction in Drosophila. Yalgin C, et al. iScience, 2020 Aug 21. PMID 32738610, Free PMC Article
  3. Expression of alternative oxidase in Drosophila ameliorates diverse phenotypes due to cytochrome oxidase deficiency. Kemppainen KK, et al. Hum Mol Genet, 2014 Apr 15. PMID 24293544, Free PMC Article
  4. Mitochondrial electron transport chain defects modify Parkinson's disease phenotypes in a Drosophila model. O'Hanlon ME, et al. Neurobiol Dis, 2022 Sep. PMID 35764292
  5. Arl2- and Msps-dependent microtubule growth governs asymmetric division. Chen K, et al. J Cell Biol, 2016 Mar 14. PMID 26953351, Free PMC Article

See all (54) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in mitochondrial electron transport, cytochrome c to oxygen IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrial respirasome assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of oxidative phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion HDA PubMed 
part_of respiratory chain complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of respiratory chain complex IV IDA
Inferred from Direct Assay
more info
 PubMed 
part_of respiratory chain complex IV IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
cytochrome c oxidase subunit 7A
Names
CG9603-PA
CG9603-PB
COX7A-PA
COX7A-PB
cytochrome c oxidase VIIa
cytochrome c oxidase polypeptide VIIa

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    8339944..8341043 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_143927.4 → NP_652184.2  cytochrome c oxidase subunit 7A, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_652184.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B9EQX3, Q9VHS2
    Related
    FBpp0081344
    Conserved Domains (1) summary
    cd00928
    Location:31 → 85
    Cyt_c_Oxidase_VIIa; Cytochrome c oxidase subunit VIIa. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...

  2. NM_001260057.1 → NP_001246986.1  cytochrome c oxidase subunit 7A, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246986.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4K6C3, D1Z3A3
    Conserved Domains (1) summary
    cd00928
    Location:40 → 94
    Cyt_c_Oxidase_VIIa; Cytochrome c oxidase subunit VIIa. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4K6C3 A0A0B4K6C3
Q8SYW9 Q8SYW9
Q9VHS2.1 Q9VHS2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous