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Mfap1a microfibrillar-associated protein 1A [ Rattus norvegicus (Norway rat) ]

Gene ID: 499878, updated on 27-Nov-2024

Summary

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Official Symbol
Mfap1aprovided by RGD
Official Full Name
microfibrillar-associated protein 1Aprovided by RGD
Primary source
RGD:1562232
See related
EnsemblRapid:ENSRNOG00000065756 AllianceGenome:RGD:1562232
Gene type
protein coding
RefSeq status
INFERRED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1562232
Summary
Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be located in centrosome; microfibril; and nucleoplasm. Predicted to be part of U2-type precatalytic spliceosome. Orthologous to human MFAP1 (microfibril associated protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Heart (RPKM 86.8), Muscle (RPKM 79.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Mfap1a in Genome Data Viewer
Location:
3q35
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (128893880..128910460, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (108440163..108456744, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (113428855..113445435, complement)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene serine incorporator 4 Neighboring gene small EDRK-rich factor 2 Neighboring gene Huntingtin interacting protein K Neighboring gene WD repeat domain 76 Neighboring gene FERM domain containing 5 Neighboring gene uncharacterized LOC120101916

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Characterization of an associated microfibril protein through recombinant DNA techniques. Horrigan SK, et al. J Biol Chem, 1992 May 15. PMID 1374398
  2. Cryo-EM Structure of a Pre-catalytic Human Spliceosome Primed for Activation. Bertram K, et al. Cell, 2017 Aug 10. PMID 28781166
  3. Phosphorylation and degradation of tomosyn-2 de-represses insulin secretion. Bhatnagar S, et al. J Biol Chem, 2014 Sep 5. PMID 25002582, Free PMC Article
  4. RNF207 exacerbates pathological cardiac hypertrophy via post-translational modification of TAB1. Yuan L, et al. Cardiovasc Res, 2023 Mar 17. PMID 35352799
  5. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of U2-type precatalytic spliceosome ISO
Inferred from Sequence Orthology
more info
  
part_of U2-type spliceosomal complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in microfibril ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
microfibrillar-associated protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001191964.1 → NP_001178893.1  microfibrillar-associated protein 1

    Status: INFERRED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    D4ACM9
    Related
    ENSRNOP00000021562.7, ENSRNOT00000021562.8
    Conserved Domains (1) summary
    pfam06991
    Location:197 → 399
    MFAP1; Microfibril-associated/Pre-mRNA processing

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    128893880..128910460 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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