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Fmnl2 formin-like 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 499797, updated on 2-Nov-2024

Summary

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Official Symbol
Fmnl2provided by RGD
Official Full Name
formin-like 2provided by RGD
Primary source
RGD:1560248
See related
EnsemblRapid:ENSRNOG00000055567 AllianceGenome:RGD:1560248
Gene type
protein coding
RefSeq status
MODEL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1560248
Summary
Predicted to enable actin filament binding activity. Predicted to be involved in cell migration; cortical actin cytoskeleton organization; and regulation of cell shape. Is active in glutamatergic synapse and postsynapse. Orthologous to human FMNL2 (formin like 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Adrenal (RPKM 122.2), Brain (RPKM 114.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Fmnl2 in Genome Data Viewer
Location:
3q12
Exon count:
29
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (57758236..58033832)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (37348791..37624746)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (38400409..38677637)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene NADH:ubiquinone oxidoreductase subunit A2, pseudogene 1 Neighboring gene developmental pluripotency associated 5A like 1 Neighboring gene uncharacterized LOC134486095 Neighboring gene uncharacterized LOC134486096 Neighboring gene pre-mRNA processing factor 40 homolog A Neighboring gene ARF like GTPase 6 interacting protein 6 Neighboring gene NADH:ubiquinone oxidoreductase subunit B1, pseudogene 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Nanoscale segregation of actin nucleation and elongation factors determines dendritic spine protrusion. Chazeau A, et al. EMBO J, 2014 Dec 1. PMID 25293574, Free PMC Article
  2. Identification and characterization of a set of conserved and new regulators of cytoskeletal organization, cell morphology and migration. Bai SW, et al. BMC Biol, 2011 Aug 11. PMID 21834987, Free PMC Article
  3. Sequential Elution Interactome Analysis of the Mind Bomb 1 Ubiquitin Ligase Reveals a Novel Role in Dendritic Spine Outgrowth. Mertz J, et al. Mol Cell Proteomics, 2015 Jul. PMID 25931508, Free PMC Article
  4. E-cadherin interactome complexity and robustness resolved by quantitative proteomics. Guo Z, et al. Sci Signal, 2014 Dec 2. PMID 25468996, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables small GTPase binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cortical actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cortical actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
involved_in cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell shape IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
is_active_in postsynapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in postsynapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
formin-like 2; formin-like protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    57758236..58033832
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039106785.2 → XP_038962713.1  formin-like protein 2 isoform X2

    Conserved Domains (3) summary
    pfam06367
    Location:278 → 475
    Drf_FH3; Diaphanous FH3 Domain
    pfam02181
    Location:622 → 973
    FH2; Formin Homology 2 Domain
    pfam06371
    Location:23 → 275
    Drf_GBD; Diaphanous GTPase-binding Domain

  2. XM_039106787.2 → XP_038962715.1  formin-like protein 2 isoform X5

    Conserved Domains (3) summary
    pfam06367
    Location:278 → 475
    Drf_FH3; Diaphanous FH3 Domain
    pfam02181
    Location:622 → 973
    FH2; Formin Homology 2 Domain
    pfam06371
    Location:23 → 275
    Drf_GBD; Diaphanous GTPase-binding Domain

  3. XM_039106784.2 → XP_038962712.1  formin-like protein 2 isoform X1

    Related
    ENSRNOP00000101642.1, ENSRNOT00000134952.1
    Conserved Domains (3) summary
    pfam06367
    Location:278 → 475
    Drf_FH3; Diaphanous FH3 Domain
    pfam02181
    Location:622 → 973
    FH2; Formin Homology 2 Domain
    pfam06371
    Location:23 → 275
    Drf_GBD; Diaphanous GTPase-binding Domain

  4. XM_017592149.3 → XP_017447638.2  formin-like protein 2 isoform X6

    UniProtKB/TrEMBL
    A0A0G2K132
    Related
    ENSRNOP00000071681.2, ENSRNOT00000085545.3
    Conserved Domains (3) summary
    pfam06367
    Location:278 → 475
    Drf_FH3; Diaphanous FH3 Domain
    pfam02181
    Location:615 → 966
    FH2; Formin Homology 2 Domain
    pfam06371
    Location:23 → 275
    Drf_GBD; Diaphanous GTPase-binding Domain

  5. XM_008761823.4 → XP_008760045.2  formin-like protein 2 isoform X8

    Conserved Domains (3) summary
    pfam06367
    Location:278 → 475
    Drf_FH3; Diaphanous FH3 Domain
    pfam02181
    Location:615 → 966
    FH2; Formin Homology 2 Domain
    pfam06371
    Location:23 → 275
    Drf_GBD; Diaphanous GTPase-binding Domain

  6. XM_008761822.4 → XP_008760044.2  formin-like protein 2 isoform X4

    UniProtKB/TrEMBL
    A0A8I6AKV5
    Conserved Domains (3) summary
    pfam06367
    Location:278 → 475
    Drf_FH3; Diaphanous FH3 Domain
    pfam02181
    Location:615 → 966
    FH2; Formin Homology 2 Domain
    pfam06371
    Location:23 → 275
    Drf_GBD; Diaphanous GTPase-binding Domain

  7. XM_039106789.2 → XP_038962717.1  formin-like protein 2 isoform X9

    Conserved Domains (3) summary
    pfam06367
    Location:227 → 424
    Drf_FH3; Diaphanous FH3 Domain
    pfam02181
    Location:571 → 922
    FH2; Formin Homology 2 Domain
    pfam06371
    Location:23 → 224
    Drf_GBD; Diaphanous GTPase-binding Domain

  8. XM_039106790.2 → XP_038962718.1  formin-like protein 2 isoform X10

    Conserved Domains (3) summary
    pfam06367
    Location:227 → 424
    Drf_FH3; Diaphanous FH3 Domain
    pfam02181
    Location:564 → 915
    FH2; Formin Homology 2 Domain
    pfam06371
    Location:23 → 224
    Drf_GBD; Diaphanous GTPase-binding Domain

  9. XM_039106786.2 → XP_038962714.1  formin-like protein 2 isoform X3

    Conserved Domains (3) summary
    pfam06367
    Location:278 → 475
    Drf_FH3; Diaphanous FH3 Domain
    pfam02181
    Location:622 → 973
    FH2; Formin Homology 2 Domain
    pfam06371
    Location:23 → 275
    Drf_GBD; Diaphanous GTPase-binding Domain

  10. XM_063284876.1 → XP_063140946.1  formin-like protein 2 isoform X3

  11. XM_039106788.2 → XP_038962716.1  formin-like protein 2 isoform X7

    UniProtKB/TrEMBL
    A0A8I6AV50
    Related
    ENSRNOP00000098738.1, ENSRNOT00000129567.1
    Conserved Domains (3) summary
    pfam06367
    Location:278 → 475
    Drf_FH3; Diaphanous FH3 Domain
    pfam02181
    Location:615 → 966
    FH2; Formin Homology 2 Domain
    pfam06371
    Location:23 → 275
    Drf_GBD; Diaphanous GTPase-binding Domain
Nucleotide Protein Strain
Heading Accession and Version

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