U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Gstm4 glutathione S-transferase mu 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 499689, updated on 4-Jan-2025

Summary

Go to the top of the page Help
Official Symbol
Gstm4provided by RGD
Official Full Name
glutathione S-transferase mu 4provided by RGD
Primary source
RGD:1565825
See related
EnsemblRapid:ENSRNOG00000019221 AllianceGenome:RGD:1565825
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
GSTM4-4
Summary
Predicted to enable several functions, including glutathione binding activity; glutathione transferase activity; and leukotriene-C4 synthase activity. Predicted to be involved in glutathione metabolic process and long-chain fatty acid biosynthetic process. Predicted to act upstream of or within nitrobenzene metabolic process and xenobiotic catabolic process. Predicted to be located in cytosol and intercellular bridge. Orthologous to human GSTM4 (glutathione S-transferase mu 4). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Liver (RPKM 256.8), Lung (RPKM 112.2) and 9 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Gstm4 in Genome Data Viewer
Location:
2q34
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (198356114..198373487, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (195667940..195685315, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (210834013..210839242, complement)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene glutathione S-transferase mu 2 Neighboring gene glutathione S-transferase mu 1 Neighboring gene small nucleolar RNA SNORA71 Neighboring gene small nucleolar RNA SNORD47 Neighboring gene adenosine monophosphate deaminase 2

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. A comparison of the enzymatic and physicochemical properties of human glutathione transferase M4-4 and three other human Mu class enzymes. Comstock KE, et al. Arch Biochem Biophys, 1994 Jun. PMID 8203914
  2. Cloning and expression of a novel Mu class murine glutathione transferase isoenzyme. Guo J, et al. Biochem J, 2002 Sep 15. PMID 12069689, Free PMC Article
  3. Maresin conjugates in tissue regeneration biosynthesis enzymes in human macrophages. Dalli J, et al. Proc Natl Acad Sci U S A, 2016 Oct 25. PMID 27791009, Free PMC Article
  4. Molecular cloning and heterologous expression of an alternatively spliced human Mu class glutathione S-transferase transcript. Ross VL, et al. Biochem J, 1993 Sep 1. PMID 8373352, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC108896

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables enzyme binding IEA
Inferred from Electronic Annotation
more info
  
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
  
enables glutathione binding IEA
Inferred from Electronic Annotation
more info
  
enables glutathione binding ISO
Inferred from Sequence Orthology
more info
  
enables glutathione transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glutathione transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables glutathione transferase activity ISO
Inferred from Sequence Orthology
more info
  
enables glutathione transferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
  
enables leukotriene-C4 synthase activity IEA
Inferred from Electronic Annotation
more info
  
enables leukotriene-C4 synthase activity ISO
Inferred from Sequence Orthology
more info
  
enables leukotriene-C4 synthase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in glutathione metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glutathione metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glutathione metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in long-chain fatty acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in long-chain fatty acid biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in long-chain fatty acid biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within nitrobenzene metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in xenobiotic catabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within xenobiotic catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in xenobiotic catabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in intercellular bridge IEA
Inferred from Electronic Annotation
more info
  
located_in intercellular bridge ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
glutathione S-transferase Mu 4
Names
GST class-mu 4
glutathione S-transferase M4
glutathione S-transferase mu 3
leukotriene C4 synthase GSTM4
NP_001019475.1
XP_038958863.1
XP_038958864.1
XP_038958865.1
XP_038958868.1
XP_063138472.1
XP_063138473.1
XP_063138474.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001024304.1 → NP_001019475.1  glutathione S-transferase Mu 4

    See identical proteins and their annotated locations for NP_001019475.1

    Status: PROVISIONAL

    Source sequence(s)
    BC091199
    UniProtKB/Swiss-Prot
    Q5BK56
    UniProtKB/TrEMBL
    B6DYQ3
    Related
    ENSRNOP00000025939.4, ENSRNOT00000025939.7
    Conserved Domains (2) summary
    cd03209
    Location:92 → 211
    GST_C_Mu; C-terminal, alpha helical domain of Class Mu Glutathione S-transferases
    cd03075
    Location:3 → 84
    GST_N_Mu; GST_N family, Class Mu subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    198356114..198373487 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039102937.2 → XP_038958865.1  glutathione S-transferase Mu 4 isoform X4

    Conserved Domains (2) summary
    cd03075
    Location:3 → 84
    GST_N_Mu; GST_N family, Class Mu subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...
    cl02776
    Location:92 → 120
    GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family

  2. XM_039102935.2 → XP_038958863.1  glutathione S-transferase Mu 4 isoform X1

    Conserved Domains (2) summary
    cd03209
    Location:45 → 164
    GST_C_Mu; C-terminal, alpha helical domain of Class Mu Glutathione S-transferases
    cl00388
    Location:3 → 37
    Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold

  3. XM_039102936.2 → XP_038958864.1  glutathione S-transferase Mu 4 isoform X2

    Conserved Domains (2) summary
    cd03209
    Location:43 → 162
    GST_C_Mu; C-terminal, alpha helical domain of Class Mu Glutathione S-transferases
    cl00388
    Location:3 → 37
    Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold

  4. XM_039102940.2 → XP_038958868.1  glutathione S-transferase Mu 4 isoform X5

    UniProtKB/TrEMBL
    A6HUX5
    Conserved Domains (1) summary
    cl02776
    Location:1 → 107
    GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family

  5. XM_063282403.1 → XP_063138473.1  glutathione S-transferase Mu 4 isoform X5

    UniProtKB/TrEMBL
    A6HUX5

  6. XM_063282404.1 → XP_063138474.1  glutathione S-transferase Mu 4 isoform X6

  7. XM_063282402.1 → XP_063138472.1  glutathione S-transferase Mu 4 isoform X3

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5BK56.1 GenPept UniProtKB/Swiss-Prot:Q5BK56

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous