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Cadps Calcium-dependent secretion activator [ Drosophila melanogaster (fruit fly) ]

Gene ID: 49968, updated on 9-Dec-2024

Summary

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Official Symbol
Cadpsprovided by FlyBase
Official Full Name
Calcium-dependent secretion activatorprovided by FlyBase
Primary source
FLYBASE:FBgn0053653
Locus tag
Dmel_CG33653
See related
AllianceGenome:FB:FBgn0053653
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:GH07283; cap; caps; Caps; CAPS; CG17881; CG18026; CG33653; CG40477; dcaps; dCAPS; Dmel\CG33653; l(4)102Fb; SDCAP
Summary
Predicted to enable calcium ion binding activity. Involved in glutamatergic synaptic transmission and synaptic vesicle exocytosis. Located in synapse. Is expressed in several structures, including NMJ bouton; adult head; ganglia; larval somatic muscle cell; and neuroblasts. Orthologous to human CADPS (calcium dependent secretion activator) and CADPS2 (calcium dependent secretion activator 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Cadps in Genome Data Viewer
Location:
102F8-102F8; 4-0 cM
Exon count:
26
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 4 NC_004353.4 (1230837..1271759)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 4 NC_004353.3 (1234563..1275485)

Chromosome 4 - NC_004353.4Genomic Context describing neighboring genes Neighboring gene mitf Neighboring gene Dual-specificity tyrosine phosphorylation-regulated kinase 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. RNA editing regulates transposon-mediated heterochromatic gene silencing. Savva YA, et al. Nat Commun, 2013. PMID 24201902, Free PMC Article
  2. Whole arm inversions of chromosome 4 in Drosophila species. Podemski L, et al. Chromosoma, 2001 Aug. PMID 11534822
  3. Heterochromatin protein 1a is required for an open chromatin structure. Cryderman DE, et al. Transcription, 2011 Mar. PMID 21468237, Free PMC Article
  4. Proteome-Wide Analysis of ADAR-Mediated Messenger RNA Editing during Fruit Fly Ontogeny. Kliuchnikova AA, et al. J Proteome Res, 2020 Oct 2. PMID 32866021
  5. Drosophila CAPS is an essential gene that regulates dense-core vesicle release and synaptic vesicle fusion. Renden R, et al. Neuron, 2001 Aug 16. PMID 11516399

See all (55) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Contributes to the instructive role of bridge-cells in embryonic trachea.
    Title: Distinct functions of the leucine-rich repeat transmembrane proteins capricious and tartan in the Drosophila tracheal morphogenesis.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

mobile_element

  • Loc: 1234105-1234445 mobile_element_type = transposon:INE-1{}3979
  • Loc: 1241115-1241458 mobile_element_type = transposon:INE-1{}3980
  • Loc: 1247285-1247633 mobile_element_type = transposon:INE-1{}5457
  • Loc: 1247634-1248167 mobile_element_type = transposon:INE-1{}5476
  • Loc: 1249348-1250418 mobile_element_type = transposon:INE-1{}3991
  • Loc: 1252868-1253001 mobile_element_type = transposon:INE-1{}3993
  • Loc: 1256227-1260813 mobile_element_type = transposon:F{}1572
  • Loc: 1257060-1258095 mobile_element_type = transposon:1360{}4082
  • Loc: 1258096-1259175 mobile_element_type = transposon:1360{}1571
  • Loc: 1261516-1261787 mobile_element_type = transposon:INE-1{}3995
  • Loc: 1263507-1263580 mobile_element_type = transposon:INE-1{}3997
  • Loc: 1265878-1266322 mobile_element_type = transposon:Cr1a{}5477
  • Loc: 1266559-1267388 mobile_element_type = transposon:Quasimodo{}4050
  • Loc: 1270253-1270622 mobile_element_type = transposon:INE-1{}4007

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables calcium ion binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in dense core granule exocytosis IEA
Inferred from Electronic Annotation
more info
  
involved_in exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in neurotransmitter secretion NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of calcium ion-dependent exocytosis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in synaptic transmission, glutamatergic IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in synaptic vesicle exocytosis IEA
Inferred from Electronic Annotation
more info
  
involved_in synaptic vesicle exocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in synaptic vesicle exocytosis ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in vesicle-mediated transport NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in synapse IDA
Inferred from Direct Assay
more info
 PubMed 
located_in synaptic vesicle NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
Calcium-dependent secretion activator
Names
CG33653-PA
CG33653-PB
CG33653-PD
CG33653-PE
CG33653-PF
Cadps-PA
Cadps-PB
Cadps-PD
Cadps-PE
Cadps-PF
Calcium-activated protein for secretion
calcium activated protein for secretion

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004353.4 Reference assembly

    Range
    1230837..1271759
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001031858.2 → NP_001027029.2  Calcium-dependent secretion activator, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001027029.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    H9XVQ4, H9XVQ5, Q4AB01, Q5LJP1, Q8IM88, Q8IM89, Q8MT21, Q9NHE5, Q9Y135
    Conserved Domains (3) summary
    cd01234
    Location:585 → 711
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam00169
    Location:593 → 699
    PH; PH domain
    pfam06292
    Location:904 → 997
    DUF1041; Domain of Unknown Function (DUF1041)

  2. NM_001258510.2 → NP_001245439.1  Calcium-dependent secretion activator, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001245439.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    H9XVQ4, H9XVQ5, Q4AB01, Q5LJP1, Q8IM88, Q8IM89, Q8MT21, Q9NHE5, Q9Y135
    Conserved Domains (3) summary
    cd01234
    Location:585 → 711
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam00169
    Location:593 → 699
    PH; PH domain
    pfam06292
    Location:904 → 1066
    DUF1041; Domain of Unknown Function (DUF1041)

  3. NM_001258511.2 → NP_001245440.1  Calcium-dependent secretion activator, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001245440.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    H9XVQ4, H9XVQ5, Q4AB01, Q5LJP1, Q8IM88, Q8IM89, Q8MT21, Q9NHE5, Q9Y135
    Conserved Domains (3) summary
    cd01234
    Location:585 → 711
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam00169
    Location:593 → 699
    PH; PH domain
    pfam06292
    Location:903 → 1065
    DUF1041; Domain of Unknown Function (DUF1041)

  4. NM_001031859.2 → NP_001027030.1  Calcium-dependent secretion activator, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001027030.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    H9XVQ4, H9XVQ5, Q4AB01, Q5LJP1, Q8IM88, Q8IM89, Q8MT21, Q9NHE5, Q9Y135
    Conserved Domains (3) summary
    cd01234
    Location:565 → 691
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam00169
    Location:573 → 679
    PH; PH domain
    pfam06292
    Location:884 → 977
    DUF1041; Domain of Unknown Function (DUF1041)

  5. NM_001031860.2 → NP_001027031.1  Calcium-dependent secretion activator, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001027031.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    H9XVQ4, H9XVQ5, Q4AB01, Q5LJP1, Q8IM88, Q8IM89, Q8MT21, Q9NHE5, Q9Y135
    Conserved Domains (3) summary
    cd01234
    Location:580 → 706
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam00169
    Location:588 → 694
    PH; PH domain
    pfam06292
    Location:899 → 1061
    DUF1041; Domain of Unknown Function (DUF1041)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9NHE5.3 Q9NHE5

Gene LinkOut

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