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Prss53 serine protease 53 [ Rattus norvegicus (Norway rat) ]

Gene ID: 499270, updated on 14-Nov-2024

Summary

Official Symbol
Prss53provided by RGD
Official Full Name
serine protease 53provided by RGD
Primary source
RGD:1566127
See related
EnsemblRapid:ENSRNOG00000026040 AllianceGenome:RGD:1566127
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Pol3s; RGD1311277; RGD1566127
Summary
Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Orthologous to human PRSS53 (serine protease 53). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Spleen (RPKM 45.2), Kidney (RPKM 37.6) and 9 other tissues See more
Orthologs
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Genomic context

See Prss53 in Genome Data Viewer
Location:
1q37
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (191923398..191931292, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (182494944..182501607, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (199331108..199337129, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene syntaxin 4 Neighboring gene zinc finger protein 668 Neighboring gene zinc finger protein 646 Neighboring gene vitamin K epoxide reductase complex, subunit 1 Neighboring gene branched chain ketoacid dehydrogenase kinase

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

General gene information

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables serine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
serine protease 53
Names
polyserase-3
protease, serine, 53
NP_001102626.1
XP_006230384.1
XP_063127472.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001109156.1NP_001102626.1  serine protease 53

    See identical proteins and their annotated locations for NP_001102626.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473956
    UniProtKB/TrEMBL
    A6I9W0, D4AAD2
    Related
    ENSRNOP00000033673.5, ENSRNOT00000035672.7
    Conserved Domains (3) summary
    smart00020
    Location:45267
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:45271
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    cl21584
    Location:302464
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    191923398..191931292 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063271402.1XP_063127472.1  serine protease 53 isoform X2

    UniProtKB/TrEMBL
    A0A8I6GKU1, A6I9V9
    Related
    ENSRNOP00000094565.1, ENSRNOT00000102265.2
  2. XM_006230322.5XP_006230384.1  serine protease 53 isoform X1

    See identical proteins and their annotated locations for XP_006230384.1

    UniProtKB/TrEMBL
    D4AAD2
    Related
    ENSRNOP00000102993.1, ENSRNOT00000157241.1
    Conserved Domains (1) summary
    cd00190
    Location:45310
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...