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Dmrtc2 DMRT-like family C2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 499100, updated on 9-Dec-2024

Summary

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Symbol
Dmrtc2provided by RGD
Full Name
DMRT-like family C2provided by RGD
Primary source
RGD:1583739
See related
EnsemblRapid:ENSRNOG00000020109 AllianceGenome:RGD:1583739
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable identical protein binding activity and sequence-specific double-stranded DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to act upstream of or within heterochromatin organization; male meiosis I; and spermatid nucleus elongation. Predicted to be located in XY body. Predicted to be active in nucleus. Orthologous to human DMRTC2 (DMRT like family C2). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in Testes (RPKM 31.9), Lung (RPKM 14.6) and 2 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Dmrtc2 in Genome Data Viewer
Location:
1q21
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (89594120..89601761)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (80466259..80473883)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (81734256..81741419)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108349556 Neighboring gene CEA cell adhesion molecule 6 Neighboring gene Ly6/Plaur domain containing 4 Neighboring gene ribosomal protein S19 Neighboring gene CD79a molecule

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. A mammal-specific Doublesex homolog associates with male sex chromatin and is required for male meiosis. Kim S, et al. PLoS Genet, 2007 Apr 20. PMID 17447844, Free PMC Article
  2. Mice deficient in Dmrt7 show infertility with spermatogenic arrest at pachytene stage. Kawamata M, et al. FEBS Lett, 2006 Nov 27. PMID 17098235
  3. Vertebrate DM domain proteins bind similar DNA sequences and can heterodimerize on DNA. Murphy MW, et al. BMC Mol Biol, 2007 Jul 2. PMID 17605809, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
NOT enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
NOT enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within heterochromatin organization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within male meiosis I ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within spermatid nucleus elongation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in XY body ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
doublesex- and mab-3-related transcription factor C2
Names
doublesex and mab-3 related transcription factor like family C2
doublesex- and mab-3-related transcription factor C2-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001109140.1 → NP_001102610.1  doublesex- and mab-3-related transcription factor C2

    See identical proteins and their annotated locations for NP_001102610.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473979
    UniProtKB/TrEMBL
    A6J915, D3ZH91
    Related
    ENSRNOP00000027242.2, ENSRNOT00000027242.7
    Conserved Domains (2) summary
    pfam15791
    Location:242 → 369
    DMRT-like; Doublesex-and mab-3-related transcription factor C1 and C2
    pfam00751
    Location:38 → 84
    DM; DM DNA binding domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    89594120..89601761
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063270853.1 → XP_063126923.1  doublesex- and mab-3-related transcription factor C2 isoform X4

  2. XM_039087146.2 → XP_038943074.1  doublesex- and mab-3-related transcription factor C2 isoform X3

    UniProtKB/TrEMBL
    A6J915, D3ZH91
    Conserved Domains (2) summary
    pfam15791
    Location:242 → 369
    DMRT-like; Doublesex-and mab-3-related transcription factor C1 and C2
    pfam00751
    Location:38 → 84
    DM; DM DNA binding domain

  3. XM_008766899.4 → XP_008765121.1  doublesex- and mab-3-related transcription factor C2 isoform X1

    UniProtKB/TrEMBL
    M0RDV0
    Conserved Domains (2) summary
    pfam00751
    Location:65 → 111
    DM; DM DNA binding domain
    pfam15791
    Location:270 → 395
    DMRT-like; Doublesex-and mab-3-related transcription factor C1 and C2

  4. XM_008766900.4 → XP_008765122.1  doublesex- and mab-3-related transcription factor C2 isoform X2

    Conserved Domains (2) summary
    pfam00751
    Location:65 → 111
    DM; DM DNA binding domain
    pfam15791
    Location:270 → 361
    DMRT-like; Doublesex-and mab-3-related transcription factor C1 and C2

RNA

  1. XR_010056132.1 RNA Sequence

  2. XR_594301.4 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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