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Arl2bp ARF like GTPase 2 binding protein [ Rattus norvegicus (Norway rat) ]

Gene ID: 498910, updated on 27-Nov-2024

Summary

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Official Symbol
Arl2bpprovided by RGD
Official Full Name
ARF like GTPase 2 binding proteinprovided by RGD
Primary source
RGD:1561471
See related
EnsemblRapid:ENSRNOG00000016991 AllianceGenome:RGD:1561471
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable transcription coactivator activity. Predicted to be involved in maintenance of protein location in nucleus and positive regulation of tyrosine phosphorylation of STAT protein. Located in mitochondrial intermembrane space. Human ortholog(s) of this gene implicated in retinitis pigmentosa with or without situs inversus. Orthologous to human ARL2BP (ADP ribosylation factor like GTPase 2 binding protein). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 388.6), Kidney (RPKM 321.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Arl2bp in Genome Data Viewer
Location:
19p13
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (10342895..10352529, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (10336921..10346555, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (10753670..10763247, complement)

Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene transfer RNA leucine (anticodon CAG) 8 Neighboring gene plasmolipin Neighboring gene ring finger and SPRY domain containing 1 Neighboring gene small nucleolar RNA SNORA5 Neighboring gene proteasome activator subunit 3 interacting protein 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Arl2 and Arl3 regulate different microtubule-dependent processes. Zhou C, et al. Mol Biol Cell, 2006 May. PMID 16525022, Free PMC Article
  2. ARL2 and BART enter mitochondria and bind the adenine nucleotide transporter. Sharer JD, et al. Mol Biol Cell, 2002 Jan. PMID 11809823, Free PMC Article
  3. BART is essential for nuclear retention of STAT3. Muromoto R, et al. Int Immunol, 2008 Mar. PMID 18234692
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
  
enables transcription coactivator activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in maintenance of protein location in nucleus ISO
Inferred from Sequence Orthology
more info
  
involved_in maintenance of protein location in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of tyrosine phosphorylation of STAT protein ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of tyrosine phosphorylation of STAT protein ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in centrosome IEA
Inferred from Electronic Annotation
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in cilium IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in midbody ISO
Inferred from Sequence Orthology
more info
  
is_active_in mitochondrial intermembrane space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial intermembrane space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial intermembrane space IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial intermembrane space ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in spindle IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ADP-ribosylation factor-like protein 2-binding protein
Names
ADP-ribosylation factor like GTPase 2 binding protein
ADP-ribosylation factor-like 2 binding protein
ARF-like 2-binding protein
binder of ARF2 protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001024906.2 → NP_001020077.1  ADP-ribosylation factor-like protein 2-binding protein isoform 1

    See identical proteins and their annotated locations for NP_001020077.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000019
    UniProtKB/TrEMBL
    A0A8I6GJE6, A6JY54
    Conserved Domains (1) summary
    pfam11527
    Location:1 → 100
    ARL2_Bind_BART; The ARF-like 2 binding protein BART

  2. NM_001399077.1 → NP_001386006.1  ADP-ribosylation factor-like protein 2-binding protein isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000019
    UniProtKB/Swiss-Prot
    Q4V8C5
    UniProtKB/TrEMBL
    A6JY53
    Related
    ENSRNOP00000023455.6, ENSRNOT00000023455.7
    Conserved Domains (1) summary
    pfam11527
    Location:22 → 132
    ARL2_Bind_BART; The ARF-like 2 binding protein BART

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086037.1 Reference GRCr8

    Range
    10342895..10352529 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006255121.5 → XP_006255183.1  ADP-ribosylation factor-like protein 2-binding protein isoform X1

    UniProtKB/TrEMBL
    A0A8I6GJE6
    Conserved Domains (1) summary
    pfam11527
    Location:14 → 121
    ARL2_Bind_BART; The ARF-like 2 binding protein BART

  2. XM_039097917.2 → XP_038953845.1  ADP-ribosylation factor-like protein 2-binding protein isoform X2

    UniProtKB/TrEMBL
    A6JY56
    Conserved Domains (1) summary
    pfam11527
    Location:1 → 88
    ARL2_Bind_BART; The ARF-like 2 binding protein BART

  3. XM_039097918.2 → XP_038953846.1  ADP-ribosylation factor-like protein 2-binding protein isoform X3

RNA

  1. XR_005496680.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q4V8C5.2 GenPept UniProtKB/Swiss-Prot:Q4V8C5

Gene LinkOut

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