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Cyp6a22 Cytochrome P450 6a22 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 49847, updated on 4-Jan-2025

Summary

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Official Symbol
Cyp6a22provided by FlyBase
Official Full Name
Cytochrome P450 6a22provided by FlyBase
Primary source
FLYBASE:FBgn0013773
Locus tag
Dmel_CG10240
See related
AllianceGenome:FB:FBgn0013773
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
6a22; BF6-2; CG10240; cyp6a22; Cyt-P450-rBF6-2; Dmel\CG10240; P-450; P450
Summary
Predicted to enable several functions, including heme binding activity; iron ion binding activity; and monooxygenase activity. Is expressed in adult head; gonad; and organism. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See Cyp6a22 in Genome Data Viewer
Location:
51C7-51D1; 2-73 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (14871366..14873705)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (10758871..10761210)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene U3 small nuclear riboprotein factor 55K Neighboring gene Pcf11 cleavage and polyadenylation factor subunit Neighboring gene Cytochrome P450 6a17 Neighboring gene Cytochrome P450 6a23

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Three second chromosome-linked clustered Cyp6 genes show differential constitutive and barbital-induced expression in DDT-resistant and susceptible strains of Drosophila melanogaster. Maitra S, et al. Gene, 1996 Nov 21. PMID 8973362
  2. Novel cytochrome P450, cyp6a17, is required for temperature preference behavior in Drosophila. Kang J, et al. PLoS One, 2011. PMID 22216356, Free PMC Article
  3. Detecting highly differentiated copy-number variants from pooled population sequencing. Schrider DR, et al. Pac Symp Biocomput, 2013. PMID 23424139, Free PMC Article
  4. Signatures of Insecticide Selection in the Genome of Drosophila melanogaster. Duneau D, et al. G3 (Bethesda), 2018 Nov 6. PMID 30190420, Free PMC Article
  5. HIF- and non-HIF-regulated hypoxic responses require the estrogen-related receptor in Drosophila melanogaster. Li Y, et al. PLoS Genet, 2013. PMID 23382692, Free PMC Article

See all (46) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

mobile_element

  • Loc: 14871387-14871435 mobile_element_type = transposon:INE-1{}5657

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables heme binding IEA
Inferred from Electronic Annotation
more info
  
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
  
enables monooxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
cytochrome P450 6a22
Names
CG10240-PA
CG10240-PB
CG10240-PC
Cyp6a22-PA
Cyp6a22-PB
Cyp6a22-PC
cytochrome P450
cytochrome P450 related BF6-2
NP_001286431.1
NP_001286432.1
NP_652075.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    14871366..14873705
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001299502.1 → NP_001286431.1  cytochrome P450 6a22, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286431.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q27592, Q9V769
    UniProtKB/TrEMBL
    A0A0B4LGH5
    Conserved Domains (1) summary
    pfam00067
    Location:35 → 491
    p450; Cytochrome P450

  2. NM_001299503.1 → NP_001286432.1  cytochrome P450 6a22, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286432.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q27592, Q9V769
    UniProtKB/TrEMBL
    A0A0B4LGH5
    Conserved Domains (1) summary
    pfam00067
    Location:35 → 491
    p450; Cytochrome P450

  3. NM_143818.3 → NP_652075.1  cytochrome P450 6a22, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_652075.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q27592, Q9V769
    UniProtKB/TrEMBL
    A0A0B4LGH5
    Related
    FBpp0086580
    Conserved Domains (1) summary
    pfam00067
    Location:35 → 491
    p450; Cytochrome P450
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4LGH5 A0A0B4LGH5
Q9V769.1 Q9V769

Gene LinkOut

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