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Lcorl ligand dependent nuclear receptor corepressor-like [ Rattus norvegicus (Norway rat) ]

Gene ID: 498385, updated on 9-Dec-2024

Summary

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Official Symbol
Lcorlprovided by RGD
Official Full Name
ligand dependent nuclear receptor corepressor-likeprovided by RGD
Primary source
RGD:1561241
See related
EnsemblRapid:ENSRNOG00000003787 AllianceGenome:RGD:1561241
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1561241
Summary
Predicted to enable histone methyltransferase binding activity. Predicted to act upstream of or within regulation of transcription by RNA polymerase II and transcription by RNA polymerase II. Predicted to be located in nucleus. Orthologous to human LCORL (ligand dependent nuclear receptor corepressor like). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in Adrenal (RPKM 64.9), Kidney (RPKM 63.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Lcorl in Genome Data Viewer
Location:
14q11
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (69482919..69620269)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (65271339..65407732)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (69765356..69898749)

Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene U7 small nuclear RNA Neighboring gene uncharacterized LOC134481688 Neighboring gene RNA polymerase III subunit F, pseudogene 2 Neighboring gene heat shock protein 90 alpha family class B member 1, pseudogene 5 Neighboring gene non-SMC condensin I complex, subunit G Neighboring gene DDB1 and CUL4 associated factor 16

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables histone methyltransferase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ligand-dependent nuclear receptor corepressor-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001432820.1 → NP_001419749.1  ligand-dependent nuclear receptor corepressor-like protein isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000014

  2. NM_001432821.1 → NP_001419750.1  ligand-dependent nuclear receptor corepressor-like protein isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000014
    UniProtKB/TrEMBL
    A0A8I6G435, A0A8I6GLM1

  3. NM_001432822.1 → NP_001419751.1  ligand-dependent nuclear receptor corepressor-like protein isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000014

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086032.1 Reference GRCr8

    Range
    69482919..69620269
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017599472.3 → XP_017454961.2  ligand-dependent nuclear receptor corepressor-like protein isoform X1

    UniProtKB/TrEMBL
    A0A8I6A139
    Conserved Domains (1) summary
    pfam15090
    Location:1424 → 1874
    DUF4553; Domain of unknown function (DUF4553)

  2. XM_039092775.2 → XP_038948703.1  ligand-dependent nuclear receptor corepressor-like protein isoform X13

  3. XM_017599474.3 → XP_017454963.2  ligand-dependent nuclear receptor corepressor-like protein isoform X3

    UniProtKB/TrEMBL
    A0A8I6A139
    Conserved Domains (1) summary
    pfam15090
    Location:1398 → 1848
    DUF4553; Domain of unknown function (DUF4553)

  4. XM_039092776.2 → XP_038948704.1  ligand-dependent nuclear receptor corepressor-like protein isoform X14

  5. XM_063273773.1 → XP_063129843.1  ligand-dependent nuclear receptor corepressor-like protein isoform X15

  6. XM_017599475.3 → XP_017454964.2  ligand-dependent nuclear receptor corepressor-like protein isoform X7

    UniProtKB/TrEMBL
    A0A8I6A139
    Conserved Domains (1) summary
    pfam15090
    Location:1328 → 1778
    DUF4553; Domain of unknown function (DUF4553)

  7. XM_017599473.3 → XP_017454962.2  ligand-dependent nuclear receptor corepressor-like protein isoform X2

    UniProtKB/TrEMBL
    A0A8I6A139
    Conserved Domains (1) summary
    pfam15090
    Location:1424 → 1874
    DUF4553; Domain of unknown function (DUF4553)

  8. XM_008770224.4 → XP_008768446.3  ligand-dependent nuclear receptor corepressor-like protein isoform X11

    UniProtKB/TrEMBL
    A0A8I6G435
    Related
    ENSRNOP00000095424.2, ENSRNOT00000101649.2
    Conserved Domains (1) summary
    pfam05225
    Location:551 → 596
    HTH_psq; helix-turn-helix, Psq domain

  9. XM_039092774.2 → XP_038948702.1  ligand-dependent nuclear receptor corepressor-like protein isoform X12

    Related
    ENSRNOP00000091243.1, ENSRNOT00000100583.2
    Conserved Domains (1) summary
    pfam05225
    Location:525 → 570
    HTH_psq; helix-turn-helix, Psq domain

  10. XM_039092778.2 → XP_038948706.1  ligand-dependent nuclear receptor corepressor-like protein isoform X17

  11. XM_039092777.2 → XP_038948705.1  ligand-dependent nuclear receptor corepressor-like protein isoform X16

  12. XM_039092771.2 → XP_038948699.1  ligand-dependent nuclear receptor corepressor-like protein isoform X9

    UniProtKB/TrEMBL
    A0A8I6A139
    Conserved Domains (1) summary
    pfam15090
    Location:1312 → 1762
    DUF4553; Domain of unknown function (DUF4553)

  13. XM_017599481.3 → XP_017454970.1  ligand-dependent nuclear receptor corepressor-like protein isoform X9

    UniProtKB/TrEMBL
    A0A8I6A139
    Conserved Domains (1) summary
    pfam15090
    Location:1312 → 1762
    DUF4553; Domain of unknown function (DUF4553)

  14. XM_063273771.1 → XP_063129841.1  ligand-dependent nuclear receptor corepressor-like protein isoform X10

    UniProtKB/TrEMBL
    A0A8I6A139

  15. XM_039092768.2 → XP_038948696.1  ligand-dependent nuclear receptor corepressor-like protein isoform X8

    UniProtKB/TrEMBL
    A0A8I6A139
    Conserved Domains (1) summary
    pfam15090
    Location:1315 → 1765
    DUF4553; Domain of unknown function (DUF4553)

  16. XM_017599482.3 → XP_017454971.1  ligand-dependent nuclear receptor corepressor-like protein isoform X9

    UniProtKB/TrEMBL
    A0A8I6A139
    Conserved Domains (1) summary
    pfam15090
    Location:1312 → 1762
    DUF4553; Domain of unknown function (DUF4553)

  17. XM_039092761.2 → XP_038948689.1  ligand-dependent nuclear receptor corepressor-like protein isoform X4

    UniProtKB/TrEMBL
    A0A8I6A139
    Conserved Domains (1) summary
    pfam15090
    Location:1390 → 1840
    DUF4553; Domain of unknown function (DUF4553)

  18. XM_039092767.2 → XP_038948695.1  ligand-dependent nuclear receptor corepressor-like protein isoform X8

    UniProtKB/TrEMBL
    A0A8I6A139
    Conserved Domains (1) summary
    pfam15090
    Location:1315 → 1765
    DUF4553; Domain of unknown function (DUF4553)

  19. XM_063273770.1 → XP_063129840.1  ligand-dependent nuclear receptor corepressor-like protein isoform X9

    UniProtKB/TrEMBL
    A0A8I6A139

  20. XM_039092772.2 → XP_038948700.1  ligand-dependent nuclear receptor corepressor-like protein isoform X9

    UniProtKB/TrEMBL
    A0A8I6A139
    Conserved Domains (1) summary
    pfam15090
    Location:1312 → 1762
    DUF4553; Domain of unknown function (DUF4553)

  21. XM_039092760.2 → XP_038948688.1  ligand-dependent nuclear receptor corepressor-like protein isoform X4

    UniProtKB/TrEMBL
    A0A8I6A139
    Conserved Domains (1) summary
    pfam15090
    Location:1390 → 1840
    DUF4553; Domain of unknown function (DUF4553)

  22. XM_039092762.2 → XP_038948690.1  ligand-dependent nuclear receptor corepressor-like protein isoform X5

    UniProtKB/TrEMBL
    A0A8I6A139
    Conserved Domains (1) summary
    pfam15090
    Location:1364 → 1814
    DUF4553; Domain of unknown function (DUF4553)

  23. XM_063273763.1 → XP_063129833.1  ligand-dependent nuclear receptor corepressor-like protein isoform X6

    UniProtKB/TrEMBL
    A0A8I6A139

  24. XM_063273765.1 → XP_063129835.1  ligand-dependent nuclear receptor corepressor-like protein isoform X6

    UniProtKB/TrEMBL
    A0A8I6A139

  25. XM_063273766.1 → XP_063129836.1  ligand-dependent nuclear receptor corepressor-like protein isoform X6

    UniProtKB/TrEMBL
    A0A8I6A139

  26. XM_063273764.1 → XP_063129834.1  ligand-dependent nuclear receptor corepressor-like protein isoform X6

    UniProtKB/TrEMBL
    A0A8I6A139

  27. XM_063273769.1 → XP_063129839.1  ligand-dependent nuclear receptor corepressor-like protein isoform X8

    UniProtKB/TrEMBL
    A0A8I6A139

  28. XM_063273762.1 → XP_063129832.1  ligand-dependent nuclear receptor corepressor-like protein isoform X6

    UniProtKB/TrEMBL
    A0A8I6A139

  29. XM_039092769.2 → XP_038948697.1  ligand-dependent nuclear receptor corepressor-like protein isoform X8

    UniProtKB/TrEMBL
    A0A8I6A139
    Conserved Domains (1) summary
    pfam15090
    Location:1315 → 1765
    DUF4553; Domain of unknown function (DUF4553)

  30. XM_063273768.1 → XP_063129838.1  ligand-dependent nuclear receptor corepressor-like protein isoform X6

    UniProtKB/TrEMBL
    A0A8I6A139

  31. XM_063273767.1 → XP_063129837.1  ligand-dependent nuclear receptor corepressor-like protein isoform X6

    UniProtKB/TrEMBL
    A0A8I6A139

  32. XM_017599479.3 → XP_017454968.1  ligand-dependent nuclear receptor corepressor-like protein isoform X8

    UniProtKB/TrEMBL
    A0A8I6A139
    Conserved Domains (1) summary
    pfam15090
    Location:1315 → 1765
    DUF4553; Domain of unknown function (DUF4553)

  33. XM_063273772.1 → XP_063129842.1  ligand-dependent nuclear receptor corepressor-like protein isoform X10

    UniProtKB/TrEMBL
    A0A8I6A139

  34. XM_039092773.2 → XP_038948701.1  ligand-dependent nuclear receptor corepressor-like protein isoform X10

    UniProtKB/TrEMBL
    A0A8I6A139
    Conserved Domains (1) summary
    pfam15090
    Location:1239 → 1689
    DUF4553; Domain of unknown function (DUF4553)
Nucleotide Protein Strain
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