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Bmp2k BMP-2 inducible kinase [ Rattus norvegicus (Norway rat) ]

Gene ID: 498333, updated on 27-Nov-2024

Summary

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Official Symbol
Bmp2kprovided by RGD
Official Full Name
BMP-2 inducible kinaseprovided by RGD
Primary source
RGD:1564828
See related
EnsemblRapid:ENSRNOG00000002040 AllianceGenome:RGD:1564828
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable phosphatase regulator activity and protein kinase activity. Predicted to be involved in protein phosphorylation. Predicted to act upstream of or within regulation of bone mineralization. Predicted to be located in nuclear speck. Orthologous to human BMP2K (BMP2 inducible kinase). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Spleen (RPKM 349.6), Thymus (RPKM 183.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Bmp2k in Genome Data Viewer
Location:
14p22
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (12785169..12882676, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (12481194..12579411, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (14126086..14226823, complement)

Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein S19 like 5 Neighboring gene U6 spliceosomal RNA Neighboring gene progestin and adipoQ receptor family member 3 Neighboring gene uncharacterized LOC134481718 Neighboring gene U4 spliceosomal RNA Neighboring gene uncharacterized LOC108352846 Neighboring gene uncharacterized LOC120096572

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Cloning and characterization of a novel protein kinase that impairs osteoblast differentiation in vitro. Kearns AE, et al. J Biol Chem, 2001 Nov 9. PMID 11500515
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables AP-2 adaptor complex binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatase regulator activity ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in positive regulation of Notch signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of bone mineralization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of bone mineralization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of clathrin-dependent endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear speck IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
BMP-2-inducible protein kinase
NP_001406727.1
XP_038948586.1
XP_038948588.1
XP_038948589.1
XP_063129527.1
XP_063129529.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001419798.1 → NP_001406727.1  BMP-2-inducible protein kinase

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000014
    Related
    ENSRNOP00000082412.2, ENSRNOT00000117991.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086032.1 Reference GRCr8

    Range
    12785169..12882676 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039092658.2 → XP_038948586.1  BMP-2-inducible protein kinase isoform X1

    UniProtKB/TrEMBL
    A0A8I6GK59, F1M7M4
    Related
    ENSRNOP00000092406.1, ENSRNOT00000101160.2
    Conserved Domains (2) summary
    cd14037
    Location:44 → 317
    STKc_NAK_like; Catalytic domain of Numb-Associated Kinase (NAK)-like Serine/Threonine kinases
    pfam15282
    Location:856 → 1122
    BMP2K_C; BMP-2-inducible protein kinase C-terminus

  2. XM_063273457.1 → XP_063129527.1  BMP-2-inducible protein kinase isoform X3

  3. XM_039092660.2 → XP_038948588.1  BMP-2-inducible protein kinase isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZTX4, F1M7M4
    Related
    ENSRNOP00000057591.5, ENSRNOT00000060868.7
    Conserved Domains (2) summary
    cd14037
    Location:44 → 317
    STKc_NAK_like; Catalytic domain of Numb-Associated Kinase (NAK)-like Serine/Threonine kinases
    pfam15282
    Location:819 → 1085
    BMP2K_C; BMP-2-inducible protein kinase C-terminus

  4. XM_039092661.2 → XP_038948589.1  BMP-2-inducible protein kinase isoform X4

    UniProtKB/TrEMBL
    F1M7M4
    Conserved Domains (2) summary
    pfam15282
    Location:626 → 892
    BMP2K_C; BMP-2-inducible protein kinase C-terminus
    cl21453
    Location:1 → 87
    PKc_like; Protein Kinases, catalytic domain

  5. XM_063273459.1 → XP_063129529.1  BMP-2-inducible protein kinase isoform X5

Nucleotide Protein Strain
Heading Accession and Version

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Chemical Information
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