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Gpr146 G protein-coupled receptor 146 [ Rattus norvegicus (Norway rat) ]

Gene ID: 498153, updated on 14-Nov-2024

Summary

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Official Symbol
Gpr146provided by RGD
Official Full Name
G protein-coupled receptor 146provided by RGD
Primary source
RGD:1560731
See related
EnsemblRapid:ENSRNOG00000001288 AllianceGenome:RGD:1560731
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1560731
Summary
Predicted to enable G protein-coupled receptor activity. Predicted to be involved in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway and regulation of cholesterol biosynthetic process. Predicted to be active in plasma membrane. Orthologous to human GPR146 (G protein-coupled receptor 146). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Heart (RPKM 311.1), Lung (RPKM 121.9) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Gpr146 in Genome Data Viewer
Location:
12q11
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (20365790..20381122, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (15251936..15267217, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (17343396..17358631, complement)

Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene similar to human chromosome 7 open reading frame 50 Neighboring gene RIKEN cDNA C130050O18 gene like Neighboring gene G protein-coupled estrogen receptor 1 Neighboring gene microRNA 339 Neighboring gene cytochrome P450, family 2, subfamily w, polypeptide 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Hypoxia activates GPR146 which participates in pulmonary vascular remodeling by promoting pyroptosis of pulmonary artery endothelial cells. Jiang Y, et al. Eur J Pharmacol, 2023 Feb 15. PMID 36638952
  2. Evidence for an interaction between proinsulin C-peptide and GPR146. Yosten GL, et al. J Endocrinol, 2013. PMID 23759446
  3. Investigation into the presence and functional significance of proinsulin C-peptide in the female germline†. Martin JH, et al. Biol Reprod, 2019 May 1. PMID 30715203

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Hypoxia activates GPR146 which participates in pulmonary vascular remodeling by promoting pyroptosis of pulmonary artery endothelial cells.
    Title: Hypoxia activates GPR146 which participates in pulmonary vascular remodeling by promoting pyroptosis of pulmonary artery endothelial cells.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables G protein-coupled receptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cholesterol biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
probable G-protein coupled receptor 146

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001109062.1 → NP_001102532.1  probable G-protein coupled receptor 146

    See identical proteins and their annotated locations for NP_001102532.1

    Status: PROVISIONAL

    Source sequence(s)
    CH474012
    UniProtKB/TrEMBL
    A6K1V9, D3ZIS6
    Conserved Domains (1) summary
    cd14990
    Location:27 → 305
    7tmA_GPR146; G protein-coupled receptor 146, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086030.1 Reference GRCr8

    Range
    20365790..20381122 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006248957.5 → XP_006249019.1  probable G-protein coupled receptor 146 isoform X1

    See identical proteins and their annotated locations for XP_006249019.1

    UniProtKB/TrEMBL
    A6K1V9, D3ZIS6
    Conserved Domains (1) summary
    cd14990
    Location:27 → 305
    7tmA_GPR146; G protein-coupled receptor 146, member of the class A family of seven-transmembrane G protein-coupled receptors

  2. XM_017598438.3 → XP_017453927.1  probable G-protein coupled receptor 146 isoform X1

    UniProtKB/TrEMBL
    A6K1V9, D3ZIS6
    Related
    ENSRNOP00000092167.1, ENSRNOT00000095799.2
    Conserved Domains (1) summary
    cd14990
    Location:27 → 305
    7tmA_GPR146; G protein-coupled receptor 146, member of the class A family of seven-transmembrane G protein-coupled receptors

  3. XM_039089691.2 → XP_038945619.1  probable G-protein coupled receptor 146 isoform X1

    UniProtKB/TrEMBL
    A6K1V9, D3ZIS6
    Conserved Domains (1) summary
    cd14990
    Location:27 → 305
    7tmA_GPR146; G protein-coupled receptor 146, member of the class A family of seven-transmembrane G protein-coupled receptors

  4. XM_039089692.2 → XP_038945620.1  probable G-protein coupled receptor 146 isoform X1

    UniProtKB/TrEMBL
    A6K1V9, D3ZIS6
    Related
    ENSRNOP00000097739.1, ENSRNOT00000106521.2
    Conserved Domains (1) summary
    cd14990
    Location:27 → 305
    7tmA_GPR146; G protein-coupled receptor 146, member of the class A family of seven-transmembrane G protein-coupled receptors
Nucleotide Protein Strain
Heading Accession and Version

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